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Daphniphyllum calycinum and Polygonum hydropiper Linn dispersible tablet for gastrointestinal health and preparation method thereof

A technology of Changweikang and dispersible tablets, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems that affect the full absorption of drugs, cumbersome coating process, and poor stability. problem, to achieve the effect of rapid disintegration and dissolution, good absorption and high bioavailability

Active Publication Date: 2013-04-24
GUIZHOU WARMEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been found in clinical medicine that Feng Liao Chang Wei Kang Tablets composed of Niu Er Feng and Polygonum Caperica have the functions of regulating Qi, invigorating the stomach, dehumidifying and dissolving stagnation, and are used for acute gastroenteritis caused by poor middle movement, Qi stagnation and dampness, and the resulting Indigestion such as abdominal distension, abdominal pain and diarrhea has achieved good clinical results, but the full absorption of the drug is often affected by the slow disintegration and dissolution, and the coating process is cumbersome, and the finished product is prone to cracking and stains. Poor stability and other defects

Method used

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  • Daphniphyllum calycinum and Polygonum hydropiper Linn dispersible tablet for gastrointestinal health and preparation method thereof
  • Daphniphyllum calycinum and Polygonum hydropiper Linn dispersible tablet for gastrointestinal health and preparation method thereof
  • Daphniphyllum calycinum and Polygonum hydropiper Linn dispersible tablet for gastrointestinal health and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Beef Ear Maple 4000g Spicy Polygonum 2000g

[0097] For the above two flavors, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 1.5 hours, add 6 times the amount of water for the second time, decoct for 1 hour, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to Thick paste, dried below 80°C, crushed into fine powder, add 24g of sodium carboxymethyl starch, 60g of cross-linked polyvinylpyrrolidone and appropriate amount of microcrystalline cellulose, mix thoroughly and then granulate, then add cross-linked polyvinylpyrrolidone 12g, 3g of magnesium stearate, 1.2g of aspartame, mixed evenly, and pressed into 1000 tablets, to obtain final product. Tablet weight 0.6g.

Embodiment 2

[0099] Beef Ear Maple 4000g Spicy Polygonum 2000g

[0100] For the above two flavors, add water to decoct twice, add 6 times the amount of water for the first time, decoct for 1.5 hours, add 4 times the amount of water for the second time, decoct for 1 hour, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to Thick paste, dry below 80°C, crush into fine powder, add 24g of sodium carboxymethyl starch, 72g of cross-linked polyvinylpyrrolidone, 1.2g of aspartame and appropriate amount of starch, mix well and granulate, then add hard Magnesium acetate 1.5g, mix well, press into 1000 tablets, and get it. Tablet weight 0.6g.

Embodiment 3

[0102] Beef Ear Maple 4000g Spicy Polygonum 2000g

[0103] For the above two flavors, add water to decoct twice, add 10 times the amount of water for the first time, decoct for 1.5 hours, add 6 times the amount of water for the second time, decoct for 1 hour, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to Thick paste, dried below 80°C, crushed into fine powder, weighing about 378g; add 24g of sodium carboxymethyl starch, 60g of cross-linked polyvinylpyrrolidone and appropriate amount of microcrystalline cellulose, mix well and granulate, then add cross-linked 12g of polyvinylpyrrolidone, 3.2g of micro-powdered silica gel, 1.5g of betaine, mix well, press into 1000 tablets, and obtain. Tablet weight 0.6g.

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PUM

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Abstract

The invention discloses a daphniphyllum calycinum and knees herb dispersible tablet for gastrointestinal health and a preparation method thereof. The traditional Chinese medicinal composition is prepared from daphniphyllum calycinum and knees herb according to a certain weight proportion, can be prepared into dispersible tablets, has the effects of regulating qi, promoting digestion, removing dampness and resolving food stagnation, and is used for treating acute gastroenteritis caused by the weakness of the spleen and the stomach, qi stagnation and dampness retention, as well as dyspepsia symptoms of abdominal distension, abdominal pain, diarrhea and the like caused by the acute gastroenteritis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and more specifically relates to a traditional Chinese medicine dispersible tablet and a preparation method thereof. Background technique [0002] Acute and chronic gastroenteritis is a common and frequently-occurring disease. Clinically, abdominal discomfort, abdominal pain, nausea and vomiting, abdominal distension and diarrhea, belching and pantothenic acid, and loss of appetite are the main clinical manifestations. The etiology of this disease is often due to overeating and unclean diet Due to history. It has been found in clinical medicine that Feng Liao Chang Wei Kang Tablets composed of Niu Er Feng and Polygonum Caperica have the functions of regulating Qi, invigorating the stomach, dehumidifying and dissolving stagnation, and are used for acute gastroenteritis caused by poor middle movement, Qi stagnation and dampness, and the resulting Indigestion such as abdominal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/32A61K36/704A61P1/14A61P1/00A61P1/12
Inventor 李仕幸
Owner GUIZHOU WARMEN PHARMA
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