The invention relates to a Chinese medicine composition for treating sepsis and a preparation method thereof. The Chinese medicine composition comprises active ingredients prepared from the following traditional Chinese medicines in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of radix scutellariae, 10-20 parts of radix salviae miltiorrhizae, 1-5 parts of Chinese rhubarb, 5-10 parts of coptis chinensis, 8-10 parts of radix paeoniae rubra, 5-10 parts of ginseng, 8-10 parts of root of rehmannia, 10-20 parts of honeysuckle, 5-10 parts of fruit of trifoliate orange and 5-10 parts of liquorice. According to the Chinese medicine composition disclosed by the invention, fungi, toxicity and inflammation are treated simultaneously by utilizing synergistic effect of various ingredients, various ways and various target points of the traditional Chinese medicines; in addition, the Chinese medicine composition has unique and exact effects of controlling sepsis in early stage and turning and cutting off the disease development, and has excellent remote effects.