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Antihepatitis medicinal composition

A technology of composition and medicine, applied in the field of medicine

Inactive Publication Date: 2007-06-13
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the use of astragalus or its extract, ganoderma lucidum or its extract, and glycyrrhizic acid or its pharmaceutically acceptable salt, and the compatibility of prescriptions for the preparation of drugs for the treatment of hepatitis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] Example 1 Preparation of astragalus extract, i.e. astragalus polysaccharide, with polysaccharide as the main active ingredient

[0142] Astragalus polysaccharide preparation process:

[0143] Take the Radix Astragali medicinal material, add 7 times the amount of 70% ethanol to extract twice, each time for 2 hours, discard the extract, take the dregs and add water to extract twice, combine the extracts, concentrate until the ratio of the volume of the extract to the raw medicinal material is 1.05: 1. Add ethanol to precipitate to make the alcohol content reach 70%, filter to obtain a precipitate, wash the precipitate with 70% ethanol, dissolve it with an appropriate amount of water, filter, pass the filtrate through a macroporous resin, elute with water, collect the washing liquid, and wash the washing liquid Concentrate to a ratio of 1:2.5 between the volume of the medicinal solution and the medicinal material, add ethanol to make the alcohol content reach 70%, and ob...

Embodiment

[0154] Example 2 Preparation of Astragalus extract with total saponins as the main active ingredient, i.e. total saponins of Astragalus

[0155] Astragalus total saponins preparation process:

[0156] Take astragalus, add water and decoct three times, 1.5 hours each time, add 10 times the amount of water for the first time, and 8 times the amount for the second and third times, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20-1.25 (60°C) , with ethanol precipitation treatment twice, the alcohol content in the solution for the first time is 75%, and the second time is 85%, each time it is refrigerated and placed, the ethanol is recovered and concentrated to 10g of the original medicinal material per 1ml, and added to the treated On a good macroporous adsorption resin column, wash the column with 2 times the volume of water, then elute with 4 times the volume of 70% ethanol, collect the eluate, concentrate under reduced pressure, and dr...

Embodiment 3

[0173] Example 3 Preparation of Ganoderma lucidum extract with polysaccharide as the main active ingredient, i.e. Ganoderma lucidum polysaccharide

[0174] Preparation technology of Ganoderma lucidum polysaccharide

[0175] Take Ganoderma lucidum, crush it into coarse grains, add 4 times the amount of water to moisten overnight, decoct three times the next day, add 12 times the amount of water to decoct for 3 hours for the first time, add 10 times the amount of water for 2 hours, and decoct for the second time Add 10 times the amount of water three times and decoct for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10-1.15, filter, use the Sevage method to remove protein from the filtrate, filter, add ethanol to the filtrate until the alcohol content is 60%, stir well, refrigerate for 24 hours, filter, collect the filter cake, add appropriate amount of water to stir and dissolve, filter, add ethanol to the filtrate until the alcoho...

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Abstract

The present invention discloses a medicine composition, its preparation method and preparation containing said medicine composition. Said medicine composition includes (b y weight portion) 500-8000 portions of astragalus root, 50-2000 portions of ganoderma and 0.4-100 portions of glycyrrhizinic acid or its pharmaceutical acceptable salt. Besides, said medicine composition also can be made up by using (by weight portion) 5-120 portions of astragalus polysaccharide, 1-32 portions of ganoderma polysaccharide and 0.4-100 portions of glycyrrhizinic acid or its pharmaceutical acceptable salt. Said medicine composition can be used for preparing the medicines capable of curing the diseases of hepatitis B, chronic hepatitis, active hepatocirrhosis and hepatic fibrosis, etc.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for treating hepatitis diseases made from astragalus or its extract, ganoderma lucidum or its extract, glycyrrhizic acid or its pharmaceutically acceptable salt, and its preparation Methods and formulations. 【Background technique】 [0002] Hepatitis is a common and frequently-occurring disease. According to incomplete statistics, hepatitis patients and virus carriers account for 10% of the total population in my country. Among them, viral hepatitis is the main one, and viral hepatitis can be divided into: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Chronic hepatitis can be divided into persistent hepatitis and active hepatitis. Hepatitis is a kind of infectious disease, because of its widespread prevalence, great harm, and high incidence rate, it is one of the difficult diseases recognized at home and abroad. Taking ...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K31/715A61P1/16A61P31/14A61P31/20A61K31/704
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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