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New composition of medication for anti cancer

A kind of composition and medicine technology, applied in the field of medicine

Inactive Publication Date: 2007-10-10
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the interaction of Gynostemma pentaphyllum, Cordyceps mycelium, cantharidin or its derivatives or its analogues and / or toad venom is used for the preparation of anticancer drugs, which has not been reported yet.

Method used

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  • New composition of medication for anti cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156] Example 1 Preparation of Gynostemma Gynostemma Extract

[0157] Take Gynostemma pentaphylla, add 75% ethanol to reflux and extract twice, each time for 2 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, add water to make a solution equivalent to 2g of crude drug per 1ml, stir well, let it cool, and let it stand Overnight, filter, and the filtrate passes through the treated macroporous resin column, first flush the column with 2 times the column volume of water, discard the water, then elute with 3 times the column volume of 60% ethanol, and collect the eluate , recovering ethanol, concentrating to a concentrated solution with a relative density of 1.08-1.10, and spray-drying to obtain.

[0158] Identification of Gynostemma Gynostemma Extract

[0159] Take Gynostemma pentaphyllum extract 0.5g, add methanol to dissolve, and make a solution containing 10mg per 1ml, as the test solution. Another Gypenoside-A reference substance was taken and...

Embodiment 2

[0166] Example 2 Preparation of Cordyceps Mycelia Extract

[0167] Take 40kg of Cordyceps mycelium culture, add water to reflux and extract three times, each time for 2 hours, combine the extracts, filter, concentrate to a relative density of 1.10-1.15, add ethanol to make the alcohol content reach 60%, refrigerate and stand for 24 hours, Filter, collect the filter cake, add appropriate amount of water to dissolve, filter, add ethanol to make the alcohol content reach 85%, refrigerate and stand for 24 hours, filter, collect the filter cake, wash with 80% ethanol, and vacuum dry to obtain.

[0168] Content Determination of Cordyceps Mycelia Extract

[0169] Preparation of reference substance solution Accurately weigh 5.0 mg of D-anhydrous glucose dried at 105°C to constant weight, place in a 25ml volumetric flask, add distilled water to volume, and shake well to obtain the reference substance solution.

[0170] Preparation of the test solution: Take 10mg of this product, disso...

Embodiment 3

[0178] Example 3 Preparation of toad venom extract

[0179] Take toad venom, crush it into fine powder, add 20 times the amount of 80% ethanol to soak, grind, refrigerate overnight, filter the next day, recover the ethanol from the filtrate until it has no alcohol smell, add 10 times the amount of water, mix well, refrigerate, and stand for 24 hours. Filtrate, concentrate the filtrate to a relative density of 1.10 to 1.15, and spray dry to obtain.

[0180] Identification of toad venom extract

[0181] Take toad venom extract 0.1g, add ethanol 10ml, heat and reflux for 30 minutes, filter, put the filtrate in a 10ml measuring bottle, add ethanol to the mark, and use it as the test solution. Separately take 0.2 g of the reference medicinal material of toad venom, and make a solution of the reference medicinal material in the same way. Then take the reference substance of lipobufagin and cinobufagin base, and add ethanol to make solutions containing 1mg per 1ml, respectively, as...

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Abstract

An anticancer medical composition for treating cancers, leukemia, hepatitis, hepatocirrhosis, etc is proportionally prepared from gynostemma pentaphyllum or its extract, cordyceps or its extract, cantharidin or its derivative or its analog, and / or toad venom or its extract. It can be used the relative medicine by mixing it with the pharmacologically acceptable auxiliaries.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition containing gynostemma or its extract, cordyceps mycelium or its extract, norcantharidin and / or toad venom or its extract, as well as its preparation method and application. 2. Background technology [0002] Cancer is a kind of disease that seriously threatens human life and health. According to statistics, about 1 million cancer patients are newly discovered in my country every year, while the world kills about 6 million people every year, and puts 10 million people on the verge of death. With the deteriorating environment of human beings, the occurrence of cancer The rate is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of human beings in the 21st century. At present, the treatment of cancer in modern medicine is mainly surgical treatment combined with radiotherapy and chemotherapy. Alth...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61P35/00A61K31/365A61K35/56A61K35/65
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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