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Heat-clearing analgesic medicinal composition with anti-infective and antiviral functions

An antipyretic analgesic and composition technology, which is applied in the field of medicine and achieves the effects of uniform and stable quality, less impurities, and reduced relative dosage

Inactive Publication Date: 2007-04-04
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the interaction of 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinic acid half-ester salt and honeysuckle is used to prepare a prescription for treating antibacterial, antiviral infection, anti-inflammatory and Antipyretic and analgesic drugs have not been reported yet

Method used

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  • Heat-clearing analgesic medicinal composition with anti-infective and antiviral functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Example 1 Preparation of Honeysuckle Extract

[0106] (1) Weigh 100kg of honeysuckle medicinal material, soak in warm water for 30 minutes, and decoct twice. Add water for the first time: 5000ml for 1 hour; add water for the second time: 5000ml for 1 hour, filter and combine the filtrates.

[0107] (2) Concentrate the filtrate to a relative density of 1.20-1.25 (70-80°C), let it cool to 40°C, slowly add ethanol to make the alcohol content reach 75%, stir well, and let stand for 12 hours.

[0108] (3) Filter the supernatant, recover the ethanol until there is no alcohol smell, add 3 to 4 times the amount of water, and let stand for 12 hours.

[0109] (4) Collect the supernatant by filtration, concentrate to a relative density of 1.15-1.20 (70-80°C), let cool to 40°C, add ethanol to make the alcohol content reach 85%, and let stand for more than 12 hours.

[0110] (5) Filter the supernatant, recover the ethanol until it has no alcohol smell, and spray dry it. The conte...

Embodiment 2

[0112] The preparation of embodiment 2 Ningjin composition powder injection

[0113] prescription:

[0114] Prescription 1

[0115] Yanhuning 40g

[0116] Honeysuckle extract 560g (equivalent to 4000g of raw medicinal materials)

[0117] EDTA-2NA 0.3g

[0118] Mannitol 300g

[0119] Add sterile water for injection to 3000ml

[0120] A total of 1000 sticks were prepared

[0121] Prescription 2

[0122] Chuan Hu Ning 40g

[0123] Honeysuckle extract 560g (equivalent to 4000g of raw medicinal materials)

[0124] EDTA-2NA 0.3g

[0125] Mannitol 300g

[0126] Add sterile water for injection to 3000ml

[0127] A total of 1000 sticks were prepared

[0128] 2. Specific steps:

[0129] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0130] 2) Weigh the raw materials and auxiliary materials according to th...

Embodiment 3

[0139] Embodiment 3 Preparation of Ningjin Composition Aqueous Injection

[0140] 1. Prescription:

[0141] Prescription 1

[0142] Yanhuning 40g

[0143] Honeysuckle extract 560g (equivalent to 4000g of raw medicinal materials)

[0144] EDTA-2NA 0.1g

[0145] Add water for injection to 1000ml

[0146] A total of 1000 sticks were prepared

[0147] Prescription 2

[0148] Chuan Hu Ning 40g

[0149] Honeysuckle extract 560g (equivalent to 4000g of raw medicinal materials)

[0150] EDTA-2NA 0.1g

[0151] Add water for injection to 1000ml

[0152] A total of 1000 sticks were prepared

[0153] 2. Specific steps:

[0154] 2) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0155] 3) Take water for injection with a dosing volume of 80%, first add EDTA-2NA to dissolve completely, then add the prescribed amount of Yanhuning (or Chuan...

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Abstract

An anti-infective and antiviral medicinal composition for antipyresis and analgesia is proportionally prepared from 14-dehydroxy-11,12-didehydro andrographolide-3,19- semi-ester succinate and honeysuckle flower or its extract. Its preparing process is also disclosed.

Description

1. Technical field [0001] The present invention relates to a medicine for anti-infection, anti-virus, antipyretic and analgesic made from 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinic acid half ester salt and honeysuckle The pharmaceutical composition, its preparation method and application belong to the technical field of medicine. 2. Background technology [0002] Due to the current spread of resistance to many traditional antibiotics such as penicillin and amoxicillin has attracted great attention and attention from the medical community, a large number of multi-drug resistant strains and the emergence of new viruses have made refractory infections more and more serious. many. At the same time, since the compatibility of natural medicines such as traditional Chinese herbal medicines or the composition of active ingredients often have complementary and synergistic effects, and do not produce drug resistance, the discovery and research of natural medicines ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/35A61K31/365A61K9/08A61P29/00A61P31/00A61P31/12
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司
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