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1423 results about "Anti infectives" patented technology
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Anti-infective means against or capable of defeating infection. This is a general term used in medicine to describe all medications or therapies that can cure or fight an infection. The term is general because there are so many types of infections, and a single anti-infective treats a specific sort of infection instead of treating them all.
Anti-infection compound preparation and its preparation method
InactiveCN1380098AImprove immunityEffective excretionAntibody ingredientsUnknown materialsSide effectSuppository
The anti-infective medicine, including powder, mixture, aerosol, capsule, injection, suppository, ointment and microcapsule, is characterized by that on the theroretical basis of combining traditional Chinese medicine and modern immunology the immunoglobulin, effective components of Chinese medicinal materials which are extracted according to the compound prescription and auxiliary preparation are combined together organically, and undergone the fine preparation process to obtain a high-efficiency, safe, stable, environment-protecting type anti-infection medicine having no toxic side effect and having no drug resistance.
Owner:张勇飞 +2
Anti-infection augmentation foamable compositions and kit and uses thereof
Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti-infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.
Owner:FOAMIX PHARMACEUTICALS LIMITED
Triclosan-containing medical devices
InactiveUS6106505ALower levelAvoiding undesirably high releaseWrappers shrinkageShrinkage connectionsTriclosanAntiinfective agent
PCT No. PCT / US96 / 20932 Sec. 371 Date Jun. 30, 1998 Sec. 102(e) Date Jun. 30, 1998 PCT Filed Dec. 23, 1996 PCT Pub. No. WO97 / 25085 PCT Pub. Date Jul. 17, 1997The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.
Owner:COLUMBIA UNIV OF THE CITY OF NEW YORK TRUSTEES OF THE
Oxidative reductive potential water solution and methods of using the same
Provided is an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours and methods of using the solution. The present invention provides a method of preventing or treating a condition in a patient, which method comprises administering a therapeutically effective amount of the ORP water solution. Additionally provided is a method of treating impaired or damaged tissue, which method comprises contacting the tissue with a therapeutically effective amount of the ORP water solution. Further provided is a method of disinfecting a surface, which method comprises contacting the surface with an anti-infective amount of the ORP water solution.
Owner:SONOMA PHARMA INC
Antiviral indoleoxoacetyl piperazine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
Owner:VIIV HEALTHCARE UK (NO 5) LTD
Agents for controlling biological fluids and methods of use thereof
InactiveUS20070059350A1Good hemostasisHigh viscosityOrganic active ingredientsBiocideMedicineIncision Site
Therapeutic formulations adapted for positive-pressure application for controlling biological fluid at a desired site in a subject, absorbent articles comprising therapeutic formulations, and anti-infective devices coated with therapeutic formulations, said formulations comprising about 25% to about 99% by weight liquid-crystal forming compound and 0% to about 75% by weight solvent. In addition, methods of using said formulations including methods for controlling biological fluid at a desired site in a subject, methods for controlling blood loss, and methods for facilitating effective closure of a vascular wound or incision site at a desired site in a subject are disclosed, the methods comprising administering particular formulations comprising liquid-crystal forming compounds and solvents that are described herein.
Owner:SOUTHEASTERN MEDICAL TECH
DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER
InactiveUS20050019927A1High efficacyStrong specificityVectorsPeptide/protein ingredientsDecreased ConcentrationIn vivo
Decreasing the expression of genes in a mammalian subject has multiple applications ranging from cancer therapy to anti-infective therapy or treatment of autosomal dominant genetic disorders. Yet, there is still a lack of efficient technologies to achieve that goal in mammalian subjects in vivo. The present invention relates to methods for decreasing gene expression by administering to a mammalian subject a recombinant adeno-associated viral vector in vivo with said vector comprising an RNA interference (RNAi) expression cassette whose RNA expression products directly or indirectly lead to a decrease in expression of the corresponding RNAi target gene. Upon successful transduction with the recombinant adeno-associated viral vector, the RNA expression products of the RNAi expression cassette will decrease the cellular concentration of the mRNA transcripts of the RNAi target gene, thus resulting in decreased concentration of the protein encoded by the RNAi target gene.
Owner:HILDINGER MARKUS +1
Treatment of pulmonary disorders with aerosolized medicaments such as vancomycin
InactiveUS20100282247A1Reduce in quantityReduce the amount requiredAntibacterial agentsAntimycoticsDiseaseGlycopeptide
A method of administering an aerosolized anti-infective, such as a glycopeptide, to the respiratory system of a patient. A ratio of an amount of the glycopeptide, such as vancomycin, delivered to the pulmonary system of the patient in a 24 hour period to a minimum inhibitory amount for the target organ for the same period is about 2 or more. A system to introduce aerosolized medicament to a patient may include a humidifier coupled to an inspiratory limb of a ventilator circuit wye, where the humidifier supplies heated and humidified air to the patient, and an endotracheal tube having a proximal end coupled to a distal end of the ventilator circuit wye. The system may also include a nebulizer coupled to the endotracheal tube, where the nebulizer generates the aerosolized medicament.
Owner:NEKTAR THERAPEUTICS INC
Dual action, inhaled formulations providing both an immediate and sustained release profile
ActiveUS20090269396A1Improve treatmentSustained release of anti-infective over timePowder deliveryBiocideDual actionAnesthesia
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Owner:GRIFOLS
Anti-infective compositions for treating disordered tissue such as cold sores
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention relates to the use of an anti-infective and / or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and / or antimicrobial active agent is an organohalide such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.
Owner:CHURCH & DWIGHT CO INC
Methods for treating cold sores with anti-infective compositions
InactiveUS6211243B1Rapid decline of infectionFast decayAntibacterial agentsBiocideDiseaseAmmonium compounds
The present invention relates to a method of treated disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The inventive method combines an anti-infective and / or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and / or antimicrobial active agent is an organohalide such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.
Owner:CHURCH & DWIGHT CO INC
Disposable sheath for specula
A speculum sheath which covers a speculum and methods for using the sheath are described herein. A variety of different types of specula may be covered with the sheath, including anal, vaginal, ear, and nasal specula. The sheath is made of a compliant or partially compliant material, including latex, vinyl, natural and synthetic rubbers, silicone, nylon, polyethylene, polypropylene, and non-degradable or degradable elastomers. The material may be transparent or opaque. In the preferred embodiment, the material is transparent. The sheath may contain one or two openings. Optionally, the sheath contains an affixing means on the inside of or at least one of the openings on the sheath to prevent slippage when in contact with the speculum. Optionally, the sheath contains an active agent, such as hemostatic agents, anti-infectives, antibiotics, antimitotics anti-inflammatory, or other chemotherapeutic agents. In the preferred embodiment, the sheath is placed on a vaginal speculum and supports loose vaginal tissue when inserted into a patient. In the most preferred embodiment, the material is transparent so that medical provider may view the lumen.
Owner:ENDOLUMINAL THERAPEUTICS
Proteins and nucleic acids from meningitis/sepsis-associated Escherichia coli
Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
Owner:GLAXOSMITHKLINE VACCINES SRL +1
Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids
Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds are disclosed. Such medical articles may include urinary catheters, central venous catheters, tracheal catheters, arterial grafts, wound dressings, sutures, or any other medical articles derived from polymeric substrates such as biomedical polyurethane, biomedical polyvinylchloride (PVC), biomedical silicon, biodegradable polymers, polytetrafluoroethylene (PTFE), etc. or from natural products including natural rubber, silk or cotton fiber. Antimicrobial compositions comprising salicylic acid and sesquiterpenoids are also disclosed.
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Anti-infective functionalized surfaces and methods of making same
InactiveUS20100215643A1Preventing pin-site infectionReduce morbidityBiocideHeavy metal active ingredientsPolymer scienceMoiety
Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.
Owner:ORTHOBOND
Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
Owner:VIIV HEALTHCARE UK (NO 5) LTD
Antimicrobial protection for implantable medical device
InactiveUS20050267543A1Simple and effective and long lastingAvoid infectionAntibacterial agentsInternal electrodesAnti infectivesMedical device
An anti-infective covering for an implantable medical device is described. The covering may be a polymeric boot that comprises an anti-infective agent in an amount effective to prevent an infection when implanted in a pocket of a patient. The boot is configured to snuggly engage at least a portion of the implantable medical device. The boot may contain a side hole that allows a housing of the implantable medical device to serve as a return electrode. The boot may be placed about the implantable medical device to render the device anti-infective.
Owner:MEDTRONIC INC
Sustained release of antiinfectives
Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 μm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
Owner:INSMED INC
Compositions and methods for dermally treating infections
InactiveUS20070196325A1Sustained release of drugReduce deliveryAntimycoticsAntiviralsSkin treatmentsSkin surface
The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug which can treat various skin infections, such as fungal, bacterial, and / or viral skin infections. The formulation can include an anti-infective drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained period of time. The non-volatile solvent system can also act as a plasticizer for the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
Owner:NUVO RES
Compact ready-to-use urethral catheter assembly with means for injecting therapeutic liquid into urethral channel
A catheter assembly suitable for intermittent catheterization comprising a cylindrical casing composed of two telescopically moveable parts one of which is connectable to and moveable with a piston which is rigidly connected to a urinary catheter. The interior of the cylindrical casing is filled with a lubricating, anesthetic, antiseptic liquid, or the like, which during catheterization is injected into the urethra and urinary bladder through the catheter under the effect of movement of the piston simultaneously with the insertion of the catheter into the urethra. The device is provided with an anti-infective cap which is inserted into the first third of the urethra and is used as a guide for inserting the catheter into the urethra without physical contact with the part if the urethra which is a harbor of infections.
Owner:BORODULIN GERMAN +1
Dual action, inhaled formulations providing both an immediate and sustained release profile
ActiveUS20090274754A1Improve treatmentReduce the probability of spreadingOrganic active ingredientsBiocideDual actionAnesthesia
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Owner:GRIFOLS
Apparatus and method for generation of a protective sleeve against infections for an artificial lead
An apparatus and method for generation of a protective sleeve against infections for a percutaneous lead through human or animal skin. The percutaneous lead (1) includes an extrusion port (7). When the lead extends through a body (3) of a patient, a pump (9) in operative connection with the lead is operative to move biocompatible liquid polymer material from a reservoir (10) through the extrusion port. As the polymer material comes in contact with body tissues of the patient it forms a protective sleeve against infections (5). The protective sleeve must be periodically clipped as it continuously or intermittently grows in an upward direction (6) outside of the body. The continual formation of the protective sleeve prevents the formation of a biofilm on the percutaneous lead that can cause the body tissue to separate from the percutaneous lead.
Owner:BIOCONCEPT
Mechanically anti-infective access system and method
InactiveUS20070225635A1Induced decreaseImprove sealingTube connectorsSuction devicesMicroorganismMedicine
A patient safety enhancing connection system and method for focusing the mechanical force of the fingers through a cannula to burst and / or wipe off bacteria to thereby mechanically reduce the number of microorganism at the connection interface. The system includes elastomeric septum which is under flow able compression having outer slitted septum face and configured to receive blunt cannula by penetration of the blunt cannula into the compressed septum. The septum face and the distal opening of the cannula are matched such that the edge of the inner wall of the cannula does not engage the septum face during the penetration process to minimize the potential transfer of microorganisms to the interior of the cannula, so that bacteria, if transferred, are preferentially transferred to the outer wall of the cannula where they are compressed, sheared or wiped off by the compressed elastomere and therefore do not reach the bloodstream.
Owner:LYNN LAWRENCE ALLAN
N-halogenated amino acids, N,N-dihalogenated amino acids and derivatives; compositions and methods of using them
ActiveUS20060247209A1Favorable therapeutic indexEfficacy can not be compromisedAntibacterial agentsBiocideDisinfectantAnti infectives
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds.
Owner:NOVABAY PHARM INC
Anti-infective iodine based compositions for otic and nasal use
InactiveUS20060280809A1Reduce odorImprove toleranceBiocideInorganic active ingredientsFree iodineCompound (substance)
Otic and nasal compositions containing any iodine-containing derivatives, including, free iodine and iodoform, are disclosed. lodoform is a potent germicidal agent which provides anti-infective benefits. The composition also contains one or more anti-inflammatory agents and one or more natural or synthetic compounds which provide analgesic benefits. The composition preferably also contains one or more natural or synthetic compounds which provides aromatic benefits. The composition may be utilized to treat otic and nasal conditions, including otitis media, by topically applying the composition to the affected tissue.
Owner:LESHCHINER ADELE K +2
Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
ActiveUS20130028960A1Good treatment effectConvenient treatmentAntibacterial agentsPowder deliveryPulmonary infectionAntiinfective agent
A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery device. A method for providing prophylaxis against a pulmonary infection in a patient and a method of reducing the loss of antiinfective encapsulated in a lipid-based composition upon nebulization comprising administering an aerosolized pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition is also disclosed.
Owner:INSMED INC
Dual action, inhaled formulations providing both an immediate and sustained release profile
ActiveUS20120244206A1Improve treatmentSustained release of anti-infective over timeAntibacterial agentsBiocideDual actionAnesthesia
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Owner:GRIFOLS
Dual action, inhaled formulations providing both an immediate and sustained release profile
ActiveUS8268347B1Improve treatmentReduce the probability of spreadingAntibacterial agentsOrganic active ingredientsDual actionAnesthesia
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Owner:GRIFOLS
Antimicrobial medical articles containing a synergistic combination of anti-infective compounds and octoxyglycerin
Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds are disclosed. Such medical articles may include urinary catheters, central venous catheters, tracheal catheters, arterial grafts, wound dressings, sutures, or any other medical articles derived from polymeric substrates such as biomedical polyurethane, biomedical polyvinylchloride (PVC), biomedical silicon, biodegradable polymers, polytetrafluoroethylene (PTFE), etc. or from natural products including natural rubber, silk or cotton fiber.
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Methods for coating and impregnating medical devices with antiseptic compositions
InactiveUS20050197634A1Growth inhibitionAvoid infectionSurgeryPharmaceutical containersMedical deviceBiomedical engineering
The present invention provides methods of coating or impregnating medical devices with an antiseptic composition that will inhibit or prevent the nosocomial infections typically associated with the use of such medical devices. The present invention further provides methods of coating or impregnating medical devices that produce devices with effective activity against infection, while avoiding destroying the devices or causing the devices to become toxic. In addition, the invention provides medical devices coated or impregnated with antiseptic compositions by the aforementioned novel methods.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
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