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Anti-infection compound preparation and its preparation method

An anti-infection and formula technology, applied in the direction of anti-infective drugs, antibodies, drug combinations, etc., can solve the problems of narrow antibacterial surface, loss of medical value, and impact on clinical application.

Inactive Publication Date: 2002-11-20
张勇飞 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They act quickly, have accurate curative effect, and strong specificity, but their antibacterial area is narrow, and they are ineffective against mixed infection and secondary infection, and sometimes they have to be treated with the above three types of drugs; moreover, they are active proteins and must be stored at low temperature. It is easy to denature and inactivate during transportation and use, and lose its medical value
Therefore, these anti-infective preparations are difficult to operate in the pharmaceutical market and lose their commercial significance, which in turn affects clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0073] This example is to prepare compound traditional Chinese medicine immunoglobulin specific anti-rotavirus preparation.

[0074] 1. Formula ingredients and parts by weight

[0075] Immunoglobulin 0.10 kg

[0076] Andrographis paniculata extract powder 0.05 kg

[0077] Ascorbic acid 0.01 kg

[0078] Edetate disodium 0.01 kg

[0079] Andrographis paniculata leaching medicine powder is obtained from the traditional Chinese medicine of Andrographis paniculata in the detoxification prescription.

[0080] 2. Preparation method

[0081] ① Preparation of immunoglobulin

[0082] a. Preparation of multivalent rotavirus antigens

[0083] Take the rotavirus diarrhea feces of infants, calves, lambs, piglets, puppies and other animals (positive for rotavirus detected by ELISA) and add an equal volume of PH7.2, 0.01M PBS and appropriate amount of glass beads to shake (130 rpm, 30 minutes), 3000 rpm / centrifugation for 20 minutes, then take the supernatant, repeat the above steps tw...

example 2

[0128] This example is to prepare compound traditional Chinese medicine immunoglobulin specific anti-vegetative and poultry pestilence preparation

[0129] 1. Recipe

[0130] (1) Total formula ingredients and parts by weight

[0131] Immunoglobulin 50.00 kg.

[0132] Compound formula leaching traditional Chinese medicine powder 10.00 kg

[0133] Sodium bisulfite 0.02 kg

[0134] Multivitamins 0.50kg

[0135] Trisodium Edetate 0.50 kg

[0136] (2) Compound formula leaching traditional Chinese medicine powder (crude medicine powder)

[0137] Take the following 12 traditional Chinese medicines to make aseptic mixed leaching Chinese medicine powder to obtain the compound formula leaching Chinese medicine powder.

[0138] a. Relief prescription: Fangfeng 1.50 kg, burdock seed 2.50 kg, kudzu root 1.50 kg, perilla leaf 1.50 kg, nepeta ear 1.00 kg.

[0139] b. Detoxification prescription: 10.00 kg of honeysuckle, 2.50 kg of forsythia, 3.00 kg of skullcap, 3.00 kg of dandelion, ...

example 3

[0182] This example is the preparation of compound traditional Chinese medicine immunoglobulin specific anti-gastroenteritis preparation.

[0183] 1. Formula

[0184] Total formula ingredients and parts by weight

[0185] Immune protein 120.00 kg

[0186] Compound formula leaching traditional Chinese medicine powder 100.00 kg

[0187] Edetate disodium 0.80 kg

[0188] Cyclodextrin 0.80 kg

[0189] ② Compound formula leaching traditional Chinese medicine powder (crude medicine powder)

[0190] Take the following 10 traditional Chinese medicines and combine them to obtain the aseptic mixed leaching Chinese medicine powder to obtain the compound formula leaching Chinese medicine powder.

[0191] a. Detoxification prescription: Hedyotis diffusa 3.50 kg, Pulsatilla 2.00 kg, Scutellaria barbata 3.00 kg, Lobelia 0.01 kg, Coptis 2.00 kg;

[0192] b. Soothing formula: Muxiang 1.00kg, Yuanhu 3.50kg;

[0193] c. Tonic formula: 2.00 kg Atractylodes macrocephala, 1.00 kg Fuqin;

[...

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Abstract

The anti-infective medicine, including powder, mixture, aerosol, capsule, injection, suppository, ointment and microcapsule, is characterized by that on the theroretical basis of combining traditional Chinese medicine and modern immunology the immunoglobulin, effective components of Chinese medicinal materials which are extracted according to the compound prescription and auxiliary preparation are combined together organically, and undergone the fine preparation process to obtain a high-efficiency, safe, stable, environment-protecting type anti-infection medicine having no toxic side effect and having no drug resistance.

Description

technical field [0001] The invention relates to an anti-infection drug, more specifically, an anti-infection preparation containing compound traditional Chinese medicine and immunoglobulin and a preparation method thereof. Background technique [0002] Drugs currently used in anti-infection include antibiotics, chemically synthesized drugs, traditional Chinese medicine and its preparations, and immunoglobulin preparations. [0003] (1) Antibiotics [0004] Such anti-infective drugs are mainly metabolites produced by microorganisms such as bacteria, fungi, and actinomycetes, as well as artificially imitated synthetic or semi-synthetic antibiotics. They have a strong inhibitory or killing effect on pathogenic microorganisms, a wide antibacterial spectrum, and good curative effect, and are widely used in the prevention and treatment of human and animal diseases. However, they have large toxic and side effects, such as natural penicillin (penicillin G), semi-synthetic penicill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P31/00
Inventor 张勇飞武洁梅蒋玉文杨百亮花群义邵文爱赵冰姜坤徐军任继林沈泽江张安文张安洲张朝兴
Owner 张勇飞
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