A novel compound pharmaceutical composition, preparation method and use thereof
A technology of composition and medicine, applied in the field of medicine
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Embodiment 1
[0139] Example 1 Preparation of Cordyceps Mycelia Extract
[0140] Take 40kg of Cordyceps mycelium culture, add water to reflux and extract three times, each time for 2 hours, combine the extracts, filter, concentrate to a relative density of 1.10-1.15, add ethanol to make the alcohol content reach 60%, refrigerate and stand for 24 hours, Filter, collect the filter cake, add appropriate amount of water to dissolve, filter, add ethanol to make the alcohol content reach 85%, refrigerate and stand for 24 hours, filter, collect the filter cake, wash with 80% ethanol, and vacuum dry to obtain.
[0141] According to the above process, three batches of extracts were prepared respectively, and the yield and content of the extracts are shown in Table 5 below.
[0142] Content Determination of Cordyceps Mycelia Extract
[0143] Preparation of reference substance solution Accurately weigh 5.0 mg of D-anhydrous glucose dried at 105°C to constant weight, place in a 25ml volumetric flask...
Embodiment 2
[0152] Example 2 Preparation of Radix Astragalus Extract
[0153] Preparation of Total Astragalus Saponins
[0154] Take 40kg of Astragalus membranaceus, add water and decoct three times, 1.5 hours each time, combine the decoctions, filter, concentrate the filtrate to a relative density of 1.20-1.25 (60°C), and use ethanol precipitation treatment twice, the alcohol content in the solution for the first time 75% for the second time, and 85% for the second time. Each time it was placed in cold storage, the ethanol was recovered and concentrated to 10 g of the original medicinal material per 1 ml, diluted with water for injection to 1 g of the original medicinal material per 1 ml, kept in cold storage for 12 hours, and filtered , the filtrate was concentrated under reduced pressure and dried in vacuo to obtain.
[0155] Three batches of total astragalus saponins were prepared respectively, and the yield and content of the extracts are shown in Table 6 below.
[0156] Identifi...
Embodiment 3
[0183] Embodiment 3 Preparation of the composition powder injection of the present invention
[0184] prescription:
[0185] Prescription 1
[0186] Cordyceps mycelium extract 34.8g (equivalent to 4kg of Cordyceps mycelium)
[0187] Matrine 600g
[0188] Polysorbate 80 50g
[0189] Mannitol 200g
[0190] Add sterile water for injection to 2000ml
[0191] A total of 1000 sticks were prepared
[0192] Prescription 2
[0193] Cordyceps mycelium extract 34.8g (equivalent to 4kg of Cordyceps mycelium)
[0194] Matrine 600g
[0195] Astragalus polysaccharide 15.6g (equivalent to 1kg of Astragalus)
[0196] Polysorbate 80 50g
[0197] Mannitol 200g
[0198] Add sterile water for injection to 2000ml
[0199] A total of 1000 sticks were prepared
[0200] Prescription 3
[0201] Cordyceps mycelium extract 34.8g (equivalent to 4kg of Cordyceps mycelium)
[0202] Matrine 600g
[0203] Astragalus total saponins 9.8g (equivalent to 1kg of Astragalus)
[0204] Polysorb...
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