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A novel compound pharmaceutical composition, preparation method and use thereof

A technology of composition and medicine, applied in the field of medicine

Inactive Publication Date: 2007-05-16
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report on the application of the interaction and compatibility of Cordyceps mycelium, matrine, and astragalus for anti-tumor

Method used

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  • A novel compound pharmaceutical composition, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] Example 1 Preparation of Cordyceps Mycelia Extract

[0140] Take 40kg of Cordyceps mycelium culture, add water to reflux and extract three times, each time for 2 hours, combine the extracts, filter, concentrate to a relative density of 1.10-1.15, add ethanol to make the alcohol content reach 60%, refrigerate and stand for 24 hours, Filter, collect the filter cake, add appropriate amount of water to dissolve, filter, add ethanol to make the alcohol content reach 85%, refrigerate and stand for 24 hours, filter, collect the filter cake, wash with 80% ethanol, and vacuum dry to obtain.

[0141] According to the above process, three batches of extracts were prepared respectively, and the yield and content of the extracts are shown in Table 5 below.

[0142] Content Determination of Cordyceps Mycelia Extract

[0143] Preparation of reference substance solution Accurately weigh 5.0 mg of D-anhydrous glucose dried at 105°C to constant weight, place in a 25ml volumetric flask...

Embodiment 2

[0152] Example 2 Preparation of Radix Astragalus Extract

[0153] Preparation of Total Astragalus Saponins

[0154] Take 40kg of Astragalus membranaceus, add water and decoct three times, 1.5 hours each time, combine the decoctions, filter, concentrate the filtrate to a relative density of 1.20-1.25 (60°C), and use ethanol precipitation treatment twice, the alcohol content in the solution for the first time 75% for the second time, and 85% for the second time. Each time it was placed in cold storage, the ethanol was recovered and concentrated to 10 g of the original medicinal material per 1 ml, diluted with water for injection to 1 g of the original medicinal material per 1 ml, kept in cold storage for 12 hours, and filtered , the filtrate was concentrated under reduced pressure and dried in vacuo to obtain.

[0155] Three batches of total astragalus saponins were prepared respectively, and the yield and content of the extracts are shown in Table 6 below.

[0156] Identifi...

Embodiment 3

[0183] Embodiment 3 Preparation of the composition powder injection of the present invention

[0184] prescription:

[0185] Prescription 1

[0186] Cordyceps mycelium extract 34.8g (equivalent to 4kg of Cordyceps mycelium)

[0187] Matrine 600g

[0188] Polysorbate 80 50g

[0189] Mannitol 200g

[0190] Add sterile water for injection to 2000ml

[0191] A total of 1000 sticks were prepared

[0192] Prescription 2

[0193] Cordyceps mycelium extract 34.8g (equivalent to 4kg of Cordyceps mycelium)

[0194] Matrine 600g

[0195] Astragalus polysaccharide 15.6g (equivalent to 1kg of Astragalus)

[0196] Polysorbate 80 50g

[0197] Mannitol 200g

[0198] Add sterile water for injection to 2000ml

[0199] A total of 1000 sticks were prepared

[0200] Prescription 3

[0201] Cordyceps mycelium extract 34.8g (equivalent to 4kg of Cordyceps mycelium)

[0202] Matrine 600g

[0203] Astragalus total saponins 9.8g (equivalent to 1kg of Astragalus)

[0204] Polysorb...

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Abstract

The invention relates to a method for preparing new compound drug, wherein it mainly comprises Cordyceps sinensis mycelium at 50-2000 deals or its extractive at 0.2-40 deals, and 10-500 deals of kuh-seng, while it also can contain 10-5000 deals of milk vetch root or the milk vetch root polysaccharide extractive at 0.1-100 deals, or the milk vetch root saponin at 0.1-100 deals. The invention can be made into oral or injection agent, with anti-cancer, antibiosis funtoins, etc.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition made from cordyceps mycelium or its extract, matrine, or from cordyceps mycelium or its extract, matrine and astragalus or its extract The prepared pharmaceutical composition, its preparation method and application. 【Background technique】 [0002] Cancer is a kind of disease that seriously threatens human life and health. According to statistical data, about 1 million cancer patients are newly discovered in my country every year, and about 6 million people are killed every year in the world, and 10 million people are put on the verge of death. With the deteriorating environment of human beings, the occurrence of cancer The rate is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of human beings in the 21st century. At present, the treatment of cancer in modern medicine is mainly surgical tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61K31/715A61K31/4375A61P35/00
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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