187results about How to "Suppress death" patented technology

The invention relates to a culture medium containing human umbilical cord mesenchymal stem cell exudates and a preparation method and applications thereof. An umbilical cord mesenchymal stem cell finite cell line is established to identify biological characteristics of the umbilical cord mesenchymal stem cell, and the preparation method for the human umbilical cord mesenchymal stem cell exudates is established to verify that the human umbilical cord mesenchymal stem cell (HUCMSC) exudates can promote cell regeneration, improve cell function and suppress cell apoptosis in vitro. A detection of enzyme-linked immunosorbent assay (ELISA) shows that human umbilical cord mesenchymal stem cell exudates contain abundant cell factors which can promote cell proliferation and suppress cell apoptosis, such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF).

The invention provides a method for preparing phospholipids type DHA through catalysis of a biological enzyme. The method includes the step of preparing phospholipids type DHA from phospholipids and substances with DHA through catalysis of the biological enzyme. DHA grease does not need to be dissociated into dissociative docosahexaenoic acid (DHA) in advance, the process operation is simple and safe, reaction byproducts are few, lots of products can be rapidly obtained after one-time operation, the operation process is simplified, and the investment of devices is reduced.

The invention discloses a processing technology for perfuming, corrosion-prevention and bacteria-prevention of folding fan bamboo ribs, and belongs to the field of folding fan bamboo material processing technologies. The processing technology is characterized by comprising the steps of preparation of an anti-bacterial and anti-corrosion solvent, preparation of anti-bacterial and anti-corrosion perfume, stewing, spraying and obtaining a patina layer. In addition, a surfactant, a detergent dispersant and sodium carboxymethylcellulose are added into the anti-bacterial and anti-corrosion solvent for use to enable all the anti-bacterial and anti-corrosion components to integrate, and the maximization and optimization of the anti-bacterial and anti-corrosion effect are realized under the synergistic effect; the bamboo ribs are subjected to phased baking perfuming by adopting pure natural plant perfume, so that fragrance can go deep into the bamboo fibers slowly, a fumigation smoke smell is avoided, and the fragrance added is fresh for a long time; the surfaces of the bamboo ribs are wiped repeatedly by cotton cloth until a glossy patina layer appears, so that anti-oxidation layers on the surfaces can be compacted, the weather resistance is effectively improved, anti-bacterial and anti-corrosion effective components going deep into the bamboo ribs are not easy to lose, and fragrance can also be slowly released; therefore, the bamboo ribs are quieter, more attractive and elegant in sense and smell.

The present invention provides a novel pharmaceutical use of 2-phenyl-1,2-benzisoselenazol-3(2H)-one or a salt thereof. 2-Phenyl-1,2-benzisoselenazol-3(2H)-one or a salt thereof exhibits an excellent suppressive effect on retinal ganglion cell death in a pharmacological test using rats, and is therefore useful as a prophylactic or therapeutic agent for an eye disease accompanied by optic nerve disorder.

It is intended to provide antibodies having a higher reactivity with amylospheroid than a reactivity with amyloid ss-fiber and so on. Some of these antibodies have an activity of inhibiting amylospheroid formation or an activity of inhibiting the induction of nerve cell death by amylospheroid. Such antibodies are usable in remedies / preventives for Alzheimer's disease, screening these drugs, detecting an individual suffering from Alzheimer's disease, reagents and so on.

The application discloses TrkB antibodies for the development of new therapeutics to treat, prevent or ameliorate respiratory disorders. The application also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat conditions associated with respiratory disorders.

The invention relates to the technical field of plant genetic engineering, and specifically relates to application of a gene GmLMM1 related to soybean phytophthora resistance. According to the presentinvention, the gene GmLMM1 involved in the regulation of soybean cell death, immune response and phytophthora resistance is cloned in soybean. PTI immune response and phytophthora resistance of plants can be negatively regulated by the GmLMM1 gene; and by reducing the expression of the GmLMM1 gene, PTI immune response of plant can be effectively enhanced, and phytophthora resistance of plants canbe increased. The clone and functional discovery of the GmLMM1 gene provide important gene foundations and theoretical support for the related mechanisms research of phytophthora resistance, providevaluable gene resources for advancing the research and application of plant defense systems and for breeding new soybean varieties with high disease resistance, and has important application value ingenetic engineering breeding of soybean disease resistance.

The invention relates to application of scutellarin shown as a formula I to the treatment of microglia-mediated diseases. Typically, the invention relates to the application of the scutellarin to the preparation of medicaments for treating and / or preventing the microglia-mediated diseases, in particular to the application of the scutellarin to the preparation of medicaments for treating and / or preventing microglia-mediated neurotoxicity-caused neural immune inflammatory diseases. The scutellarin has the novel functions of remarkably inhibiting the generation of inflammatory mediators, namely nitric oxide (NO), a tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta which activate microglia, inhibiting the expression of inducible nitric oxide synthase (iNOS), TNF alpha and IL-1beta messenger ribonucleic acid (mRNA), inhibiting the generation of reactive oxygen species in the microglia, reducing the activation of nuclear factor (NF)-kappa B and remarkably alleviating the cytotoxicity of the microglia to neurons. Therefore, the scutellarin can be applied to the prevention and treatment of brain immune inflammatory related diseases such as Parkinson's disease and the like. The formula I is shown in the specifications.