34results about How to "Simple and safe process operation" patented technology

The invention provides a medical titanium implant micro-arc oxidation film layer and a preparation method. The medical titanium implant micro-arc oxidation film layer comprises a matrix and an oxidization film layer formed on the surface of the matrix, wherein a plurality of micro holes are distributed in the surface of the oxidization film layer; the micro holes consist of a plurality of micro bosses and grooves; the bosses are inwards sunken to form concave holes; the grooves are distributed in the peripheries of the bosses; the bosses are protruded relative to the grooves; the grooves are in an irregular state; the adjacent grooves are communicated with each other; and the oxidation film layer has color. The film layer provided by the invention has hydrophilicity, high-strength binding force and color. The medical titanium implant micro-arc oxidation film layer is simple in operation and preparation process, is relatively low in cost, and the obtained film layer is excellent in performance, and is suitable for industrial production.

The invention discloses a preparation method of 3,4-diacetoxy-1-butene. The preparation method comprises steps as follows: an esterification step: 1,4-butylene glycol and acetic acid are subjected to an esterification reaction in the presence of acid, a solution containing 1,4-diacetoxy-2-butene and acetic acid is obtained, acetic acid is removed and 1,4-diacetoxy-2-butene is obtained; an isomerization step: cuprous catalysts are added to 1,4-diacetoxy-2-butene obtained in the esterification step, the mixture is heated for an isomerization rearrangement reaction, and a mixed solution containing 3,4-diacetoxy-1-butene is obtained; a purification step: the mixed solution obtained in the isomerization step is purified, and 3,4-diacetoxy-1-butene is obtained. The preparation method adopts easy-to-realize reaction conditions and has the characteristic of high yield.

The invention relates to a preparation method of anidulungin side chain intermediate p-amyloxy terbenzoic acid. The method comprises the following steps: S1: 4-hydroxy-4'-bromobiphenyl and 1-bromopentane undergo a nucleophilic substitution reaction to obtain 4'-bromo-4-n-pentyloxybiphenyl; S2: 4'-bromo ‑4‑pentyloxybiphenyl and tetrahydroxydiboron undergo Suzuki coupling reaction to obtain 4‑pentyloxy‑4'‑biphenylboronic acid; S3: 4‑pentyloxy‑4'‑biphenylboronic acid and 4‑ Methyl iodobenzoate undergoes a Suzuki coupling reaction to obtain methyl 4''-(pentyloxy)-[1,1',4',1''-terphenyl]-4-formate; S4: hydrolysis to obtain p- Pentoxy terbenzoic acid. The present invention adopts Suzuki coupling to prepare aryl boronic acid and then prepares the target product through Suzuki coupling and alkali hydrolysis, which has the advantages of low cost, simple and safe process operation.

The invention discloses potentilla discolor bunge teabags with the effect of reducing blood sugar and lipids and a preparation method for the potentilla discolor bunge teabags, and belongs to the technical field of blood processing. The preparation method comprises the following steps: separating roots, stems and leaves of potentilla discolor bunge, performing extraction with different solvents respectively, mixing extracting solutions, performing reduced-pressure concentration to obtain a whole-herb extracting solution of the potentilla discolor bunge, and collecting extracted root particles as carriers; uniformly stirring and mixing the whole-herb extracting solution and the carriers, and performing baking and frying until flavor is disseminated; and cooling and quantitatively bagging the mixture to obtain potentilla discolor bunge teabag finished products. According to the method, the stems, leaves and roots of the potentilla discolor bunge are extracted with different solvent systems respectively, so that the extraction rate of active substances is increased; the extracted root particles are adopted for adsorbing extracts as the carriers, so that the functional activity of the plants is greatly developed; the prepared teabags have remarkable DPP-4 suppression activity, and have the effects of reducing blood sugar and lipid levels, promoting insulin secretion and alleviating diabetes; a process is easy to operate, and the finished products are brown in color, rich in aroma and suitable for industrial production.

The invention relates to a preparation method of 4-methyl-5-ethoxyxazole, a key intermediate of vitamin B6, and belongs to the technical field of preparation of raw materials. The preparation method of 4-methyl-5-ethoxyxazole described in the present invention, first in the hydrolysis reaction kettle, drop into 4-methyl-5-ethoxyl-1,3-oxazole-2 sequentially in a certain proportion ‑Ethyl carboxylate, toluene, drinking water and sodium hydroxide, stir and keep warm for reaction; separate liquid, use hydrochloric acid to adjust the pH value of the aqueous phase in the range of 1.0‑2.5; add organic solvent to the system obtained in the second step, 30‑50 °C Control the temperature and react until no carbon dioxide is released; after decarboxylation, adjust the pH value to ≥9.0, separate the liquids, and distill the organic phase under reduced pressure to obtain the intermediate 4-methyl-5-ethoxyoxazole. The technological operation is simple and safe, and the industrial production is easy.

The invention relates to a synthesis method of antioxidant 1076 using solid base catalyst. The 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate and the octadecanol are used as raw materials which are subjected to the interesterification reaction in the presence of a solid base catalyst to obtain the product of antioxidant 1076 with the purity more than or equal to 97.5% and the yield more than or equal to 85%. Compared with the prior art, the method provided by the invention utilizes the prepared solid base catalyst, thus the catalysis effect is improved, and the quality of obtained products is stable; in addition, the solid base catalyst is recyclable and environmental friendly, and the process operation is safe and convenient, therefore the method is suitable for the industrialized and mass production.

The invention discloses a method for synthesizing perfluoroisobutyronitrile, which is prepared by using industrial products hexafluoropropylene and chloroformate as raw materials. The reaction route is: chloroformate and hexafluoropropylene under the action of fluoride salt One-pot reaction synthesis of heptafluoroisobutyrate; heptafluoroisobutyrate reacts with ammonia to obtain heptafluoroisobutyramide; heptafluoroisobutyramide is dehydrated with a dehydrating agent and purified by rectification to obtain perfluoroisobutyronitrile ( 2,3,3,3-tetrafluoro-2-trifluoromethylpropionitrile). The raw materials selected in the method are all commercially available, and the main raw materials chloroformate and hexafluoropropylene are low in cost and can be supplied in large quantities; the reaction conditions are mild, and the reaction conversion rate and yield are high; the products of each step are easy to separate, and the product purity is high. High, simple and safe process operation, easy to industrial production.

The invention provides a preparation method of 2-chloro-5-nitropyridine. 2-Hydroxy-5-nitropyridine is prepared by two methods with 2-nitroacetaldehyde acetal as the initial raw material; then 2-hydroxy-5-nitropyridine and chlorination reagent are prepared by chlorination reaction to prepare 2-chloro ‑5‑nitropyridine. The method of the invention has cheap and easy-to-obtain raw materials and low cost; does not involve diazotization hydrolysis reaction, and is safe and convenient to operate; does not use mixed acid, produces less waste water, and is environmentally friendly; at the same time does not involve nitrification reaction, has high reaction selectivity and few side reactions , the post-treatment is simple, the product yield and purity are high, and it is suitable for industrial production.

The invention discloses a synthetic method of anti-tumor molecular targeted drug crizotinib, belongs to the field of pharmaceuticals, and relates to a synthetic method of a crizotinib intermediate. The method comprises two reduction processes: a bromination reaction process comprises the following reaction steps: a reduction process I: carrying out reduction reaction on a (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-nitropyridine compound and sodium dithionate under a mechanical chemical condition to generate (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-aminopyridine; a reduction process II: dissolving the (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-nitropyridine compound into an organic solvent, carrying out catalytic hydrogenation and reduction treatment to generate (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-aminopyridine; the bromination reaction process comprises a step of carrying out reaction between the compound and potassium hydrogen persulfate as well as bromate to obtain the crizotinib intermediate. The process is low in cost, the raw materials are easy to purchase, the operation is simple, convenient and safe, and the yield is high; moreover, the process is suitable for large-scale production.