34 results about "Iobenzamic acid" patented technology

The invention relates to a preparation method of Iopromide. 3-methoxy acetamino-5-(2,3-dihydroxy n-propylamine formyl)-2,4,6-triiodide benzoic acid shown as a formula (9) is used as an intermediate to provide a cheaper and more reasonable method for synthesizing Iopromide with high yield and purity.

The invention discloses a synthesis method of 5-bromo-2,2-dimethyl-5-(4-methylsulfonylphenyl)furan-3(2H)-one, which belongs to the technical field of organic synthesis and comprises the following steps : 4-methylthiobenzaldehyde reacts with lithium salt of [(1,1-dimethyl-2-propynyl)oxy] trimethylsilane to generate formula (I) compound; formula (I) compound Oxidation reaction with Oxone and o-iodobenzoic acid generates the compound of formula (II); the compound of formula (II) reacts with sulfuric acid to generate the compound of formula (III); the compound of formula (III) reacts with NBS to obtain the target product; the present invention The raw material is simple, the price is low, the operation is simple, the production cycle is short, and the generation of chromium-acid waste water and nitrogen-containing waste water is avoided, the environmental protection pressure is small, and industrial production is easy to realize.

The invention belongs to the technical field of photosensitive materials, in particular to a photo-induced nonlinear expansion coordination polymer and a preparation method thereof. The coordination polymer is a bright yellow bulk crystal with the chemical formula [Zn(iba)(tkpvb)Cl] n1 , where iba represents p-iodobenzoate, tkpvb represents 1,2,4,5-tetrakis((E)-2-(4-pyridyl)vinyl)benzene, n=3000-60000; crystallographic parameters are : (1) Crystal system: monoclinic system; (2) Space group: Cc; (3) β=127.430(4)°, (4) Z=4; (5) F(000)=1680, R 1 =0.1363, wR 2 =0.3788, GOF=1.620; wherein, iba represents p-iodobenzoate, tkpvb represents 1,2,4,5-tetrakis((E)-2-(4-pyridyl)vinyl)benzene, n1=3000- 60000. The preparation method of the coordination polymer of the invention is simple, the reaction conditions are mild, and the light conversion rate is fast; at the same time, the addition reaction can occur under the irradiation of light of different wavelengths, the photo-induced nonlinear expansion performance of the material is exhibited, and the corresponding isomeric compounds.

The invention provides a method for preparing a compound containing isochroman-1-one skeleton, specifically methyl o-iodobenzoate substituted with substituents and 1, The 1-disubstituted olefin is used as a raw material, and a compound containing an isochroman-1-one skeleton is prepared through a cross-coupling reaction. The method does not use any directing group, and no additional steps are required to introduce or remove the directing group; the method has a wide range of functional groups and the tolerance of the functional group; the method has the advantages of cheap and easy-to-obtain raw materials, simple steps, and high overall yield of synthesis , The advantages of low total cost of synthesis. The prepared isochroman-1-one skeleton-containing compound has broad application prospects in the synthesis of pesticides, pharmaceutical intermediates, complex natural products, and the like.

The invention discloses a preparation method of 2,4-difluoro-5-iodobenzoic acid. 2,4-difluorobenzoic acid is taken as a starting material, sodium percarbonate and elemental iodine are taken as green iodination reagents, a mild iodination reaction is performed under an acidic condition, and a high-purity target product is obtained. The synthetic process is environment-friendly and suitable for large-scale industrial production, and aftertreatment is convenient.

The invention discloses a preparation method of an OLED (Organic Light Emitting Diode) luminescent material for manufacturing novel display equipment. The OLED luminescent material comprises the following raw materials in parts by weight: 5-10 parts of cororene, 3-5 parts of anthraquinone, 5-8 parts of N-allyl-4-bromo-1,8-naphthalimide, 10-12 parts of p-chloropyrazolone, 5-8 parts of resveratrol,8-10 parts of 8-hydroxy porphyrin aluminum, 90-120 parts of triethylamine, 20-25 parts of diluted hydrochloric acid with the mass fraction of 5%, 150-180 parts of ethyl acetate, 10-15 parts of methylalcohol, 2-5 parts of potassium carbonate, 20-25 parts of dichloromethane, 160-200 parts of ultrapure water, 0.5-0.8 part of methyl 4-iodobenzoate, 0.2-0.5 part of bis(triphenylphosphine)palladium dichloride, 1-2 parts of triphenylphosphine, 8-10 parts of copper iodide, 10-15 parts of sodium hydroxide, 5-8 parts of absolute ethyl alcohol, 8-10 parts of diluted hydrochloric acid with the mass fraction of 3%, 5-10 parts of benzylamine, 5-8 parts of dicyclohexylcarbodiimide, 10-15 parts of 4-dimethylaminopyridine, 20-30 parts of tetrahydrofuran and 5-10 parts of a doping agent. The OLED luminescent material has the technical advantages that red, yellow, green and blue fluorescence spectrums and phosphorescence spectrums can be observed at the same time, and the quantum efficiency is remarkably improved.

The invention relates to a synthetic method for a 17Z-(1-hydroxy-2-oxo-1- ethylidene) androstenone derivative. The synthetic method comprises the following steps of mixing a catalyst 2-iodobenzoic acid and an oxidant potassium hydrogen persulfate to produce a mixture glucocorticoid, adding a DMSO solvent, performing a mixing and stirring reaction and a quenching reaction, and conducting extraction, washing and drying to boil off the solvent, then performing column chromatography to obtain the target compound 17Z-(1-hydroxy-2-oxo-1- ethylidene) androstenone derivative. (Please see the formula in the description) The synthetic method for the 17Z-(1-hydroxy-2-oxo-1- ethylidene) androstenone derivative has the advantages of being high in selectivity, capable of preparing a single stereoselective product, high in the target compound yield and capable of meeting the needs in scientific researches and practical application.

The invention discloses a method for synthesizing 2-halo-5-iodobenzoic acid. The method comprises the following steps: 2-halogen-5-iodobenzoic acid can be obtained by one-step iodination of o-halobenzoic acid in an iodo reagent. The post-treatment is quenched by pouring the reaction liquid into a cold reducing aqueous solution, evaporating the solvent to dryness, recrystallizing, and filtering to obtain the product. The method of the invention has short reaction route, simple operation, environmental friendliness, safety, economy and wide application prospect.

The invention relates to the preparation method of anidulafungin side chain intermediate 4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylic acid. The preparation method includes the steps of S1, subjecting 4 hydroxy-4'-bromobiphenyl and 1-bromopentane to nucleophilic substitution to obtain 4'-bromo-4-n-amyloxybiphenyl; S2, subjecting the 4'-bromo-4-n-amyloxybiphenyl and tetrahydroxydiboron to Suzuki coupling reaction to obtain 4-pentyloxy-4'-biphenylboronic acid; S3, subjecting the 4-pentyloxy-4'-biphenylboronic acid and methyl 4-iodobenzoate to Suzuki coupling reaction to obtain methyl 4''-(pentyloxy)-[1,1',4'-1''-terphenyl]-4-formate; S4, hydrolyzing to obtain 4''-(pentyloxy)-[1,1':4',1''-terphenyl]-4-carboxylic acid. arylboronic acid is prepared through Suzuki coupling; the target product is then prepared through Suzuki coupling and alkali hydrolysis; the preparation method has the advantages of low cost and good process operation simplicity and safety.

A synthetic method of 2-chloro-5-iodobenzoic acid is disclosed. The target product is obtained by subjecting methyl 2-aminobenzoate to iodination, substitution, a Sandmeyer reaction and hydrolysis under alkaline conditions. The method is characterized by modification or optimization of process steps and parameters based on traditional iodination, substitution, the Sandmeyer reaction and hydrolysis. The method is simple in process, easy in operation, safe in production process, free of pollution, and high in yield of each step. The purity of the product is 95-98%. The total yield of the product is 64-70%.

The invention relates to a preparation method of (2-(2-amino-phenyl-mercapto)-phenyl)-(4-(2-(2-hydroxy-ethoxy)-ethyl)-piperazine-1-yl)-ketone and a hydrochloride thereof. The preparation method comprises the following steps of (1) enabling 2-iodobenzoic acid and thionyl chloride to perform substitution reaction so as to generate 2-iodoebenzoyl chloride; (2) enabling the 2-iodoebenzoyl chloride and 1-(2-(2-hydroxyethoxy)-ethyl)-piperazine to perform the substitution reaction so as to generate a compound 1; and (3) enabling the compound 1 and 2-amino-thiophenol to perform the substitution reaction in the presence of an acid binding agent so as to generate the (2-(2-amino-phenyl-mercapto)-phenyl)-(4-(2-(2-hydroxy-ethoxy)-ethyl)-piperazine-1-yl)-ketone. By adopting the synthesis route disclosed by the invention, the total yield can be above 40%, the purity of the obtained product can achieve 99%, and the preparation method disclosed by the invention has the advantages of easiness in obtaining the used raw materials, simplicity in operation, mild reaction conditions and lower cost.