287 results about "Asarone" patented technology

The Chinese herbal medicine germicide is prepared with ten kinds of Chinese medicinal materials including cocklebur fruit, phellodendron bark, cnidium fruit, flavescent sophora root, alum, etc. in certain weight proportion. The Chinese herbal medicine germicide has broad spectrum bacteriostasis activity and high safety on plant and human body, and may be used widely in producing green food material.

The invention relates to an Aarin preparation for injection and preparing process wherein the formula comprises asarone 4.0-16g, Twain-80 60.0g, sodium acid sulfite 1.5g, calcium disodium edeate 0.3g, mannitol 200.0g, and water for injection to 2500ml.

The present invention relates to a novel neolignan (NEOLASA-I) 3-ethyl-2-methyl-3-(2'',4'',5''-trimethoxy-phenyl-1-(2',4',5'-trimethoxy)phenyl-1-(2',4',5'-trimethoxy)phenyl-1-propene and a process for the preparation of high purity, higher yield neolignan, alpha-asarone, 2,4,5-trimethoxy-phenyl propionone from beta-asarone or beta-asarone rich Acorus calamus oil containing alpha and gamma-asarone by hydrogenating and dimerizing by treatment with DDQ in presence of an organic acid.

The Yimaikang dispersion tablet consists of fleabane extractum and medicine carrier. Its recipe includes fleabane extractum, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, cross-linked polyvidon, steviosin, alcohol, fine silica gel powder and magnesium stearate. The dispersion tablet can disintegrate completely in 3 min to reach homogeneous dispersive state and its effective component andrographolide has dissolving rate reaching 60 % in 10 min. It is used in treating ischemic cerebral vascular diseases, cerebral hemorrhage sequela, vein obstruction, etc. and has fast acting, good taste and convenient taking.

The invention provides a microencapsulated drug additive, a preparation method and application thereof, relates to a drug additive and a preparation method thereof and provides a microencapsulated drug additive which is formed by enclosing drugs with cyclodextrin and applied to sanitary towels / pads. The microencapsulated drug additive comprises a drug core and an inclusion complex, wherein the inclusion complex is cyclodextrin, and the drug core consists of menthol, borneol and volatile oil of Chinese herbs, wherein the volatile oil of Chinese herbs is the extracts of rhizoma cyperi, artemsia argyi, Chinese angelica, cassia twig and asarum. The method comprises the steps of extracting the volatile oil of Chinese herbs by adopting supercritical CO2, then dissolving the menthol and the borneol in the volatile oil of Chinese herbs, and finally microencapsulating the drug core by the inclusion complex in a ratio of 1 to 6-10 to obtain a white powder inclusion compound-the microencapsulated drug additive. The microencapsulated drug additive prepared is spread between a skin-friendly layer and a water absorbing layer of a sanitary towel / pad evenly or concentratedly, so as to play a role in removing smell, sterilizing and health care and cooling.

The invention relates to an external plaster for preventing disease and a manufacturing method thereof. The external plaster for preventing the disease mainly comprises raw white mustard seed, raw gansui root, rhizoma corydalis, manchurian wildginger, borneol and ginger juice, wherein the raw white mustard seed, the rhizoma corydalis, the raw gansui root, the manchurian wildginger and the borneol are mixed in a weight ratio of 0.5 to 1: 0.5 to 1: 0.5 to 1: 0.5 to 1:0.1 to 0.2 to prepare a plaster main medicament. The method comprises the following steps of: selecting high-quality Chinese medicinal plants; mixing and crushing the raw white mustard seed, the rhizoma corydalis, the raw gansui root and the manchurian wildginger according to proportion; adding the borneol and the ginger juice; heating the mixture to 50 DEG C and blending; adding Vaseline as excipient; making medicinal cakes with the size of 2*0.5 cm; and packing the medicinal cakes in vacuum for later use. The improved plaster for preventing the disease has the advantages of constant treatment effect, less stimulus to skin and easy acceptance by patients.

The invention relates to a method for preparing asaryl sub-micro-emulsion, which comprises that dissolving the insoluble drug asaryl into oil, adding emulsifier, auxiliary emulsifying agent and other additives, to prepare the water-coat-oil sub-micro-emulsion. The sub-micro-emulsion carrier can improve the solubility of asaryl, to obtain uniform liquid agent. And the diameter of sub-micro-emulsion is lower than 500nm, which will not accumulated and laminate at room temperature in two years, with stable quality. The invention can be made into injection, atomization agent or nasal feeding agent, with high effect than oral agent. And the invention can avoid organic solvent and towen dissolvent to improve safety. The inventive asaryl sub-micro-emulsion can be used to treat bronchial asthma, or the like.

The invention provides an alpha-asarone mixed micelle injectio, adopting alpha-asarone of which the chemical name is 2,4,5-trimethoxy-1- propenylbenzene as an active ingredient, and adopting a cholate / phospholipid mixed micelle system for preparing the injectio. The invention not only effectively solves the problem of hard water dissolution of the alpha-asarone, but also greatly increases the drug-loading rate of the micelle injectio. The mixed micelle injectio prepared by the invention has the advantages of favorable stability and simple preparation process.

The invention relates to a Chinese medicine composite used for treating rheumatoid arthritis which belongs to the field of external applying and infusing Chinese medicine products. The technical proposal is that the composite comprises the materials according to the parts by weight as follows: 15 to 18 parts of Angelica sinensis, 15 to 18 parts of safflower, 15 to 18 parts of garden balsam stem, 15 to 18 parts of medical cyathula root, 15 to 18 parts of szechuan aconite, 15 to 18 parts of wild aconite, 10 to 18 parts of asarum, 10 to 15 parts of frankincense, 10 to 15 parts of myrrh, 15 to 20 parts of nidus vespae, 10 to 15 parts of mulberry twig, 5 to 8 parts of borneol, 10 to 15 parts of clematis root, 15 to 20 parts of pepper stem, 15 to 20 parts of astragalus root, 10 to 15 parts of rhizoma cibotii, 10 to 15 parts of heracleum hemsleyanum michaux, 10 to 15 parts of cassia twig, 10 to 15 parts of lycopodium calvatum, 10 to 15 parts of artemisia leaf, 10 to 15 parts of rhizoma ligustici wallichii and 8 to 10 parts of whole worm. The composite which is compatible with various materials has the efficacies of stimulating circulation to end stasis, relieving rigidity of muscles and activating collaterals, easing joint movement, dispersing cold and relieving pain, etc.

Disclosed is a medical pillow for treating hypertension and its preparing process, wherein the pillow inner includes the following herbs (by weight parts): wild chrysanthemum flower 800-1200, root bark of tree peony 100-300, dahurian angelica root 100-300, rhizome of Sichuan lovage 300-500, asarum herb 50-150, radix salvia miltiorrhiza 100-300, pubescent angelica root 50-150, selfheal 50-150, baikal skullcap root 50-150, eucommia bark 50-150, tetrandra root 50-150 and artemisia capillaris thunb 50-150. The preparing process of the pillow consists of proportioning the herbs, crushing into fine particles having a size of mung beans, mixing homogeneously with wild chrysanthemum flower, and loading into cloth bags of the pillow inners.

The present invention relates to a process for the preparation of high purity and yield alpha-asarone, trans 2,4,5-trimethoxy cinnamaldehyde, 2,4,5-trimethoxy-phenyl propionone, from beta-asarone or beta-asarone rich Acorus calamus oil containing alpha and gamma-asarone by hydrogenating, followed by treatment with DDQ with or without solid support of silica gel or alumina in dry organic solvent and alpha-asarone can also be obtained by treating the hydrogenated product of beta-asarone or beta-asarone rich Acorus calamus with DDQ in an aqueous organic solvent to obtain an intermediate 2,4,5-trimethoxy phenyl propionone, which in turn is reduced with sodiumborohydride to obtain the corresponding 2,4,5-trimethoxy-phenyl propanol and followed by final treatment with a dehydrating agent.

The invention provides a standard fingerprint of fleabane phenol bulk drugs and preparations, an establishment method and application. The technical schemes comprise the determination of the standard fingerprint and the characteristic fingerprint peak of fleabane drug materials, the fleabane phenol bulk drugs and the preparations, and the application of the standard fingerprint in the aspects of extraction and processing, and quality control in the process of producing the fleabane phenol bulk drugs and the preparations. Therefore, the overall monitoring of the process and the quality from the fleabane drug materials to fleabane phenol bulk drugs and then the preparations can be realized, basic substances of the fleabane drug materials, the fleabane phenol bulk drugs and the preparations can be conveniently confirmed, and the production process and quality can be conveniently evaluated, and standard indications can be provided for subsequent process improvement and perfection.

The invention provides an alpha-asarone injection. In the preparation of the alpha-asarone injection, alpha-asarone (with the chemical name of 2,4,5-trimethoxy-1-propenylbenzene) is used as an activecomponent and carbowax-12-hydroxy stearate is adopted as a solubilizing agent to prepare an injection, thereby effectively solving the problem that the asarone is not dissolved in water, and greatly enhancing the medicament carrying quantity of the injection. The injection prepared by the preparation method has the advantages of good stability and simple preparation technology.

The invention discloses an oral administration pharmaceutical composition for treating cervical vertebra diseases, which is prepared from Chinese angelica root, drynaria, eucommia bark, epimeddium, tortoise shell, deglued antler powder, ledebouriella root, Ligusticum wallichii, wood louse, cassia twig, spatholobus stem, prepared rhizome of rehmannia, dragon's bone, oyster shell, kudzu vine root, astragalus root, Clematis chinensis, root of herbaceous peony, dahurian angelica root, large-leaf gentian root, peach kernels, safflower, cyperus tuber, earthworm and asarum herb. The medicament should be decocted in water for the oral dose.

The present invention discloses one kind of dry AAA emulsion and its preparation and application, and the dry AAA emulsion has asarol as effective component, emulsifier and other supplementary material. The dry AAA emulsion has mature technological process, easy industrial production, high stability, high curative effect and other advantages. It is applied mainly in clinical treatment of bronchitis, lung infection, asthma and other diseases.

The production process of alpha-asarone includes the following production stages: acetylation reaction, methylation reaction, hydroformylation reaction, vinylation reactin and re-crystallization. The artificial synthesis process of alpha-asarone has high yield of alpha-asarone, low cost, high purity up to 98.5 %, no carcinogenic substance safrole contained in the volatile oil, no toxic matter and no side effect and can meet clinical requirement.

This invention relates to a method for synthesizing alpha-asarone. The eliminating reagents are ethyl acetate and acetic anhydride. The weight / volume ratio of 2,4,5-trimethoxybenzaldehyde to ethyl acetate is 1:(5-50), and that of 2,4,5-trimethoxybenzaldehyde to acetic anhydride is 1:(0.5-5). Organic acids are removed by sodium carbonate aqueous solution. Ethyl acetate is separated by molecular distillation. The alpha-asarone crystal is obtained by recrystallization. The method has such advantages as high product purity, simple process, low production cost, easy industrialization, and good product physicochemical properties. The alpha-asarone product can be directly added into medicines.

Disclosed is a safe substance which can inhibit the activity of aromatase (an enzyme capable of converting androgen into estrogen) to thereby effectively treat and / or prevent a sex hormone-dependent disease such as breast cancer occurring in a female person after menopause, as well as a climacteric disorder in a male person and metabolic syndrome caused by the accumulation of a visceral fat. Specifically disclosed is a therapeutic and / or prophylactic agent for a sex hormone-dependent disease, which is characterized by comprising at least one herbal extract selected from the group consisting of “Kokeiten” (golden root), prunella spike, sweet hydrangea leaf, milk thistle, a jasmine tea, “Bokusoku” (a bark of Quercus acutissima or a closely related plant thereof), “Tencha” (sweet tea), “Karensou” (Eclipta prostrata), “Youbaihi” (a bark of Myrica rubra Sie b. et Zucc.), French maritime pine, betel palm, asparagus, “Rouro” (a root of Rhaponticum unifloru m DC. or Echinops latifolius Tausch), “Ryoukyou” (a rhizome of Alpinia officinarum Hance), rooibos tea, rhubarb, pu-erh tea, green tea, “Ougon” (a root of Scutellaria baicalensis Georgi), St. John's wort (Hypericum perforatum L.), licorice, “Senrikou” (Senecio scandens Buch.-Ham.), wintergreen, “Kashi” (a matured fruit of Terminalia chebula Retz.), “Yagotou” (a bark of Mallotus japonicus), polygnum root, barrenwort (Epimedium Herb), guarana, “Ouhi” (a bark of Prunus jamasakura Sieb. ex. Koidz. or a closely related plant thereof), Argy's wormwood, sticky rehmannia, Japanese cornel, Asiasarum root, cinnamon, peony root, pine needle and amla fruit.

The invention provides a formula of asarone for injection and a preparation method thereof. In the invention, an injection is prepared by using asarone as a main ingredient, Tween-80 and polyethylene glycol (PEG)-400 as solubilizer and mannitol as an excipient, and the solubility of the asarone is improved effectively; and thus, the medicine carrying capacity of the injection is increased. The injection prepared by the invention has high re-solubility and product stability, and the preparation process is simple.

The invention provides an alpha-asarone injection. The alpha-asarone injection is prepared by taking alpha-asarone (the chemical name is 2, 4, 5-triethoxy 1-propenylbenzene) as an active ingredient, and adopting polyethylene glycol-12-hydroxystearic acid as a solubilizer, adopting propylene glycol and ethanol as cosolvents. According to the alpha-asarone injection, not only the problem that asarone can not be dissolved in water can be effectively solved, but also the safety and the stabilization of the asarone injection are improved greatly. The asarone injection prepared by the invention has good stability and is simple in preparation process.

The invention discloses a method for synthesizing alpha-asarone, including the alpha / beta-asarone mixture obtained from the wittig reaction in the existing technique, then employing the alpha / beta-asarone mixture as raw materials, according to the ratio of raw materials : solvent=1 : 1-100 to dissolve the alpha / beta-asarone mixture, adding 0.025mol%-5mol% iodine catalyst into the solution and changing cis-form asarone into anti-form asarone by stirring with the solvent reflux temperature of 0-120 DEG C. The invention can control the content of cis-form asarone which has toxic side-effect, thereby obtaining acceptable product. The invention has the advantages of short synthesizing line, mild reaction, simple and easy operation, which greatly reduces cost and is adapted for mess product in industry.

The present invention provides one kind of lipid micropherical asarol preparation, which has alpha-asarol as active component and pharmaceutically used oil, emulsifier and water for injection and oral preparation. The lipid micropherical asarol preparation has high heat stability, no obvious change in physical and chemical properties in appertizing, high safety, no hemolysis, no allergy and no irritation.

The invention discloses medicinal liquor for treating rheumatoid arthritis, which is prepared from the following raw materials in parts by weight: 10 to 20 parts of japanese snailseed root, 20 to 40 parts of large-leaved gentian, 30 to 50 parts of pawpaw, 12 to 25 parts of silkworm excrement, 10 to 20 parts of lycopodium clavatum, 10 to 20 parts of erodium stephanianum willd, 15 to 25 parts of kadsura pepper stem, 10 to 20 parts of erythrina indica lam, 20 to 40 parts of medicinal cyathula root, 30 to 50 parts of suberect spatholobus stem, 10 to 20 parts of Chinese taxillus twig, 15 to 25 parts of elder, 20 to 40 parts of paniculate swallowwort root, 20 to 40 parts of red-rooted salvia root, 15 to 30 parts of bighead atractylodes rhizome, 15 to 30 parts of Chinese atractylodes, 20 to 40 parts of cinnamon, 5 to 12 parts of asarum, 10 to 20 parts of eucommia ulmoides, 30 to 50 parts of tiger-bone, 20 to 35 parts of peony root, 15 to 30 parts of Chinese angelica, 20 to 35 parts of cassia twig, 10 to 20 parts of doubleteeth pubescent angelica root, 15 to 30 parts of ramulus mori, and 3,000 to 4,000 parts of distilled spirit. The medicinal liquor for treating rheumatoid arthritis has the effects of activating blood flow and expelling wind, relaxing tendons and unblocking collateral, dispelling cold and removing rheumatism, warming meridians and removing dampness, stopping pain and relieving stasis and the like.

The invention relates to a traditional Chinese medicine composition of a medicinal pillow for treating cervical spondylosis in the field of bedding health protection products. The traditional Chinese medicine composition comprises the following raw materials in weight portion: 20 to 30 portions of angelica, 20 to 30 portions of chuanxiong rhizome, 15 to 30 portions of dragon blood, 20 to 40 portions of mulberry branch, 20 to 30 portions of safflower, 15 to 25 portions of boswellin, 15 to 25 portions of myrrh, 20 to 30 portions of radix salviae miltiorrhizae, 15 to 20 portions of asarum herb, 25 to 30 portions of Chinese clematis, 20 to 30 portions of earthworm, 20 to 30 portions of calamus, 20 to 30 portions of ledebouriella root, 20 to 30 portions of American lopseed, 15 to 25 portions of prepared aconitum Chinese Paxton, 15 to 20 portions of camphor, 20 to 30 portions of pawpaw, 15 to 25 portions of panicled swallowwort root, 30 to 40 portions of argyi leaf, and 10 to 20 portions of borneol. The traditional Chinese medicine composition which has reasonable crude drug selection and accurate compatibility has the effects of stimulating blood circulation and removing blood stasis, unblocking channels and relieving pains, dispelling wind evils and eliminating dampness, and refreshing and restoring consciousness. The medicinal pillow has a good curative effect on the nerve root type sympathetic type cervical spondylosis and has assistant therapeutic action on migraine and neurasthenia.

A process for preparing the shortscape fleabane injection used to treat the cardiovascular and cerebrovascular ischemic diseases features that the ultrafiltration with ceramic membrane is used to remove the vegetative macro-molecular impurities, and the macroreticular adsorption resin is used to enrich, separate and purify the active components in shorts cape fleabane, including flavonoside, breviscapine B, and caffeoyl compounds.

A Chinese medicine in the form of dripping pill for promoting blood circulation, invigorating the pulse beat and relaxing pain is prepared from 4 Chinese-medicinal materials: asarum herb, ginkgo leaf, red sage root and borneol, the polyethanediol 6000, and methyl silica oil. Its advantages are high curative effect and no toxic by-effect.

The present invention relates to an asarone injection emulsion and its preparation method. Its composition includes active component asarone and medicinal auxiliary material which can be selected from injection vegetable oil, emulsifying agent and isoosmotic regulating agent. Said asarone injection emulsion can be used for resisting bacteria, relieving inflammation, stopping cough, expelling phlegm, relieving asthma, relieving convulsion and resisting epilepsy, etc.

The invention relates to a traditional Chinese medicine composition for treating a chronic obstructive pulmonary disease, which is prepared from the following active pharmaceutical ingredients: 10-15g of red ginseng, 10-15g of radix astragali, 10-15g of radix glycyrrhizae preparata, 10-15g of asarum, 10-15g of Brassica alba boiss, 10-15g of radix salviae miltiorrhizae, 10-15g of stemona, 10-15g of dried orange peel, 10-15g of Plantain seed, 10-15g of snakegourd fruit, 10-15g of perilla seed, 10-15g of almond, 10-15g of gecko, 10-15g of lumbricus, 10-15g of pseudo-ginseng powder, 10-15g of dried ginger and 10-15g of schisandra fruit. The active pharmaceutical ingredients adopted by the invention have mild properties, have the effects of invigorating qi, relieving asthma, promoting the dispersing function of the lung, sending down abnormally ascending, tonifying the kidney and consolidating the basis. The traditional Chinese medicine composition for treating a chronic obstructive pulmonary disease has the advantages of simple preparation process, wide medicine source, low cost and favorable curative effect. The clinical test on 40 patients proves that the effective rate is up to 90%.

The invention relates to a method for synthesizing alpha-Asarone, which uses hydroquinone as raw material to synthesize 1, 2, 4-trimethoxybenzene through oxidizing, triacetylizing and methylating and is characterized in using 1, 2, 4-trimethoxybenzene as raw material to prepare alpha-Asarone through directly propionylating reaction of propionic acid, reduction and dehydration. The raw material of each step in the synthesizing path of alpha-Asarone is easily obtained without using toxic organic solvent and the product needn't separate to obtain alpha-Asarone directly and the production the yield is improved greatly. The total yield reaches 65%-86%, the purity reaches over 98%, further the operation is simple and the post-treatment problem of propionylated mother liquid is solved.

The invention relates to an Aarin preparation for injection and preparing process wherein the formula comprises asarone 4.0-16g, Twain-80 60.0g, sodium acid sulfite 1.5g, calcium disodium edeate 0.3g, mannitol 200.0g, and water for injection to 2500ml.