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Microencapsulation medicament additive, preparation and application thereof

A technology of microencapsulation and additives, applied in pharmaceutical formulations, pharmaceutical sciences, plant raw materials, etc., can solve problems such as cumbersome modification process, and achieve the effects of avoiding the decline of curative effect, eliminating human body odor, and low moisture absorption.

Inactive Publication Date: 2009-02-18
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the modification process in this method is cumbersome

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 350g Cyperus Cyperi, 350g Artemisia argyi, 350g Angelica, 100g Guizhi, and 75g Asarum, and grind them into powder; put the mixed Chinese medicine powder into supercritical CO 2 Fluid extraction tank, preheated at 50°C for 10 minutes. Use 25MPa in the extraction kettle, 50°C, static extraction for 10min, then dynamic 5h, supercritical CO regulated with 10% ethanol 2 CO in fluid 2 The flow rate is 1000kg / h, and the flow rate of ethanol is 100kg / h; after the active ingredients are extracted, they pass through a filter, a heat exchanger, and enter the separation kettle after depressurization; 2 The fluid is both depressurized and cooled, so that the active ingredients are in CO 2 The volatile oil of traditional Chinese medicine is obtained when the solubility difference in the fluid is released.

[0021] Dissolve 10 g of menthol and 5 g of borneol in 25 g of volatile oil of traditional Chinese medicine to prepare a drug core to be clathrated, which is sealed for fut...

Embodiment 2

[0025] Take 750g Cyperus cyperi, 750g mugwort leaves, 750g angelica, 300g cassia twig, and 150g asarum and grind them into powder; put the mixed Chinese medicine powder into supercritical CO 2 Fluid extraction kettle, preheated at 60°C for 8 minutes. Use 35MPa in the extraction kettle, 60°C, static extraction for 10min, then dynamic 7h, supercritical CO regulated by 10% ethanol 2 CO in fluid 2 The flow rate is 1100kg / h, and the flow rate of ethanol is 110kg / h; after the active ingredients are extracted, they pass through a filter, a heat exchanger, and enter the separation kettle after depressurization; the separation kettle is 8MPa, 40°C, and the volatile oil of traditional Chinese medicine is obtained.

[0026] Dissolve 10 g of menthol and 5 g of borneol in 40 g of volatile oil of traditional Chinese medicine to prepare a drug core to be clathrated, which is sealed for future use.

[0027] Weigh 60g of β-CD, add 1140ml of distilled water, and stir to prepare a saturated aq...

Embodiment 3

[0030] Take 250g Cyperus Cyperi, 250g Artemisia argyi, 250g Angelica, 50g Guizhi, and 50g Asarum and grind them into powder for later use. Fill the mixed traditional Chinese medicine powder into supercritical CO 2 For the fluid extraction kettle, preheat at 45°C for 10 minutes. In the extraction kettle, 28MPa and 45°C were used for static extraction for 9 minutes, then dynamic for 4.5 hours, and supercritical CO regulated by 10% ethanol. 2 CO in fluid 2 The flow rate is 900kg / h, and the flow rate of ethanol is 90kg / h; after the active ingredients are extracted, they pass through a filter, a heat exchanger, and enter the separation kettle after decompression; the separation kettle is 6MPa, 30°C, and the volatile oil of traditional Chinese medicine is obtained.

[0031] Dissolve 10 g of menthol and 5 g of borneol in 35 g of volatile oil of traditional Chinese medicine to prepare a drug core to be clathrated, which is sealed for future use.

[0032] Weigh 32g of β-CD, add 900m...

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PUM

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Abstract

The invention provides a microencapsulated drug additive, a preparation method and application thereof, relates to a drug additive and a preparation method thereof and provides a microencapsulated drug additive which is formed by enclosing drugs with cyclodextrin and applied to sanitary towels / pads. The microencapsulated drug additive comprises a drug core and an inclusion complex, wherein the inclusion complex is cyclodextrin, and the drug core consists of menthol, borneol and volatile oil of Chinese herbs, wherein the volatile oil of Chinese herbs is the extracts of rhizoma cyperi, artemsia argyi, Chinese angelica, cassia twig and asarum. The method comprises the steps of extracting the volatile oil of Chinese herbs by adopting supercritical CO2, then dissolving the menthol and the borneol in the volatile oil of Chinese herbs, and finally microencapsulating the drug core by the inclusion complex in a ratio of 1 to 6-10 to obtain a white powder inclusion compound-the microencapsulated drug additive. The microencapsulated drug additive prepared is spread between a skin-friendly layer and a water absorbing layer of a sanitary towel / pad evenly or concentratedly, so as to play a role in removing smell, sterilizing and health care and cooling.

Description

technical field [0001] The invention relates to a pharmaceutical additive and a preparation method thereof, in particular to a microencapsulated pharmaceutical additive and a preparation method thereof which have the functions of deodorization, sterilization and health care and can be applied to sanitary napkins / sanitary pads. Background technique [0002] Sanitary napkins / sanitary pads are already indispensable in women's daily life. They have special functions such as antibacterial, treatment, and health care. They can prevent and treat various gynecological diseases, especially menstrual symptoms. Drug sanitary napkins / sanitary pads with special properties Pads are also not uncommon. At present, there are many formulas for medicated sanitary napkins / sanitary pads, but the main methods of adding drugs are as follows: The first method is to directly grind some Chinese and Western medicines or Chinese medicine extracts into powder, and sprinkle them on the skin-friendly laye...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61K36/8905
Inventor 戴李宗刘艳玲许一婷蒋妮娜
Owner XIAMEN UNIV
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