The invention discloses a skin-friendly cotton soft nonwoven fabric used for diapers, protective pads, and urine pads and a manufacturing method thereof. It includes a matrix layer, the matrix layer has two upper and lower sides, a layer of obliquely crossed ultrafine fiber layers is respectively arranged on the upper and lower sides of the matrix layer, and a layer of obliquely intersected ultrafine fiber layers is respectively arranged between the obliquely intersected ultrafine fiber layers. Hydrophilic layer, the preparation of the skin-friendly cotton soft non-woven fabric used for diapers, panty liners, and urine pads includes polymer feeding, melt extrusion, filtration, metering, web forming, coiling, and post-processing. The invention optimizes the existing melt-blown non-woven fabric process, introduces polyester staple fibers, improves the defects of poor hydrophilicity, tight structure, high water absorption resistance, low bulkiness, and poor hand feeling, and improves the bulkiness of non-woven fabrics Compared with the existing non-woven fabrics, the non-woven fabrics have significantly improved water absorption and wicking performance.