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Prepn. method and application of injection contg. Erigeron breviscapus

The technology of Dengzhanxixin and injection preparation is applied in the field of preparation of Dengzhanxixin injection preparation, which can solve the problems of poor practicability and unfavorable industrial production.

Active Publication Date: 2007-04-18
广东星昊药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN03117754.9 discloses "Scutellarin and its preparation method and its application in pharmacy". The preparation method of scutellarin effective part of scutellaria is separated by macroporous resin, but there is no macroporous The resin is preferred, and the total caffeic acid ester is extracted by using the organic solvent ethyl acetate at the same time. This preparation method is not practical, and the separation process uses a large amount of organic reagents, which is not conducive to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] (1) Preparation of effective parts of Erigeron breviscapus

[0120] The whole herb of Erigeron breviscapine was taken, crushed into a coarse powder, and the medicinal material was refluxed and extracted three times with 6 times the amount of 50% ethanol aqueous solution, each time for 1.5 hours. Filtrate, discard the residue, combine the extracts, recover the ethanol under reduced pressure from the medicinal solution until it has no alcohol smell, adjust the pH value of the recovered solution to 6.5 with sodium hydroxide, and filter through ceramic membrane ultrafiltration to remove plant macromolecular impurities; the ultrafiltrate is adjusted with hydrochloric acid The pH value is 5.0, concentrated under reduced pressure to 1g / ml, the concentrated solution is subjected to macroporous resin chromatography, eluted with water first, and then eluted with 20% ethanol, the ethanol eluate is collected, and the pH value is adjusted to 1.0 with concentrated hydrochloric acid, a...

Embodiment 2

[0126] (1) Preparation of effective parts of Erigeron breviscapus

[0127]The whole herb of Erigeron breviscapine was taken, crushed into a coarse powder, and the medicinal material was reflux extracted three times with 7 times the amount of 55% ethanol aqueous solution, each time for 2 hours. Filtrate, discard the residue, combine the extracts, recover the ethanol under reduced pressure from the medicinal solution until it has no alcohol smell, adjust the pH value of the recovered solution to 6.8 with sodium bicarbonate, and pass through ceramic membrane ultrafiltration to remove plant macromolecular impurities; the ultrafiltrate is adjusted with hydrochloric acid pH value is 5.5, concentrated under reduced pressure to 1.5g / ml, the concentrated solution is subjected to macroporous resin chromatography, firstly eluted with water, and then eluted with 25% ethanol, the ethanol eluate is collected, and the pH value is adjusted to 1.5 with concentrated hydrochloric acid. Stand sti...

Embodiment 3

[0133] (1) Preparation of effective parts of Erigeron breviscapus

[0134] The whole herb of Erigeron breviscapine was taken, crushed into a coarse powder, and the medicinal material was reflux extracted three times with 8 times the amount of 60% ethanol aqueous solution, each time for 2.5 hours. Filtrate, discard the residue, combine the extracts, recover the ethanol from the liquid under reduced pressure until it has no alcohol smell, adjust the pH value of the recovered liquid to 7.0 with sodium carbonate, and ultrafilter through ceramic membranes to remove plant macromolecular impurities; adjust the pH of the ultrafiltrate with hydrochloric acid Value 6.0, concentrated under reduced pressure to 2.5g / ml, macroporous resin chromatography on the concentrated solution, first eluted with water, then eluted with 30% ethanol, collected the ethanol eluate, adjusted the pH value to 2.0 with concentrated hydrochloric acid, and statically Place for 18 hours, centrifuge, and recrystal...

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Abstract

A process for preparing the shortscape fleabane injection used to treat the cardiovascular and cerebrovascular ischemic diseases features that the ultrafiltration with ceramic membrane is used to remove the vegetative macro-molecular impurities, and the macroreticular adsorption resin is used to enrich, separate and purify the active components in shorts cape fleabane, including flavonoside, breviscapine B, and caffeoyl compounds.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method and application of escutellaria breviscapine injection preparation. Background technique [0002] Cardiovascular and cerebrovascular diseases have always plagued western developed countries, and its mortality rate ranks first among various diseases. According to statistics, the number of deaths from cardiovascular and cerebrovascular diseases in the United States accounts for 50% of the total number of deaths from diseases, becoming the number one killer that threatens human health. In recent years, with the rapid development of my country's economy and the improvement of people's living standards, the incidence and mortality of cardiovascular and cerebrovascular diseases such as coronary heart disease, stroke, and hypertension have also risen linearly. In my country, 2.5 million people die of cardiovascular and cere...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P9/10A61P7/02
Inventor 张树祥阚迎昕
Owner 广东星昊药业有限公司
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