Dry asarol emulsion and its prepn and application
The technology of brain stem emulsion and Asarum brain is applied in the field of pharmaceutical dosage forms in the field of medical technology, which can solve the problems of reducing and reducing the volume of pharmaceutical compositions, and achieve the effects of high curative effect, improved stability and curative effect, and controllable drug content.
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Embodiment 1
[0045] 1) Evenly disperse 0.2 g of asarone in 2 ml of soybean oil for injection;
[0046] 2) Mix 20g of soybean lecithin for injection with an appropriate amount of water for injection, and add 20g of lidocaine;
[0047] 3) Add 1) to the stirring 2), stir at 30°C at high speed to form colostrum, and use a high-pressure homogenizer to repeatedly homogenize the solution to obtain a uniform emulsion;
[0048] 4) Adjust the pH value of the emulsion between 5-9 and stir evenly;
[0049] 5) Add 8% sucrose solution as a protective agent, and add water for injection to 1000ml;
[0050] 6) obtain white block through freeze-drying process, fill with nitrogen, obtain dry asarum emulsion;
[0051] 7) Add water to the prepared dry emulsion according to the required amount, revert to emulsion after hydration and shaking.
Embodiment 2
[0053] 1) In the preparation equipment, 0.5 g of asarone is dissolved in 1 ml of soybean oil for injection;
[0054] 2) Mix 10 g of lecithin for injection with an appropriate amount of water;
[0055] 3) Add 2) into 1) under the condition of stirring, and after stirring at 30° C., pass through a homogenizer to homogenize the solution repeatedly to obtain a uniform solution. Prepare a total of 2000ml of liquid medicine;
[0056] 4) Add 5% mannitol as a protective agent, pass through a 0.22um microporous membrane to produce bacteria, aseptically repackage under 100-grade conditions, remove moisture through freeze-drying, and fill with nitrogen to obtain dry asarum stem emulsion;
[0057] 5) Add water to the prepared dry emulsion according to the required amount, revert to emulsion after hydration and shaking.
Embodiment 3
[0059] 1) Evenly disperse Asarone 0.1g in 60ml soybean oil for injection;
[0060] 2) Mix 12g of soybean lecithin for injection and TPGS with an appropriate amount of water for injection;
[0061] 3) Add 1) to the stirring 2), stir at 30°C at high speed to form colostrum, and use a high-pressure homogenizer to repeatedly homogenize the solution to obtain a uniform emulsion;
[0062] 4) Adjust the pH value of the emulsion between 3-5 and stir evenly;
[0063] 5) Add 8% sucrose solution as a protective agent, and add water for injection to 1000ml;
[0064] 6) obtain white block through freeze-drying process, fill with nitrogen, obtain dry asarum emulsion;
[0065] 7) The prepared dry emulsion is added to NaCl solution in required amount, hydrated and shaken, and then restored to emulsion.
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