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Medicinal composition of oxymatrine, ganoderma lucidum and astragalus

A kind of composition, the technology of matrine, applied in the field of medicine

Inactive Publication Date: 2007-06-13
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the use of matrine, ganoderma lucidum or its extracts and astragalus or its extracts for the interaction of compatible prescriptions for the preparation of drugs for the treatment of liver diseases has not been reported

Method used

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  • Medicinal composition of oxymatrine, ganoderma lucidum and astragalus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0196] Example 1 Preparation of Ganoderma lucidum polysaccharide

[0197] Take Ganoderma lucidum, crush it into coarse grains, add 4 times the amount of water to moisten overnight, decoct three times the next day, add 12 times the amount of water to decoct for 3 hours for the first time, add 10 times the amount of water for 2 hours, and decoct for the second time Add 10 times the amount of water three times and decoct for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10-1.15, filter, use the Sevage method to remove protein from the filtrate, filter, add ethanol to the filtrate until the alcohol content is 60%, stir well, refrigerate for 24 hours, filter, collect the filter cake, add appropriate amount of water to stir and dissolve, filter, add ethanol to the filtrate until the alcohol content is 85%, stir well, refrigerate for 24 hours, filter After washing, collect the filter cake, add appropriate amount of acetone and ethanol to...

Embodiment 2

[0206] Example 2 Preparation of astragalus polysaccharide

[0207] Take the Radix Astragali medicinal material, add 7 times the amount of 70% ethanol to extract twice, each time for 2 hours, discard the extract, take the dregs and add water to extract twice, combine the extracts, concentrate until the ratio of the volume of the extract to the raw medicinal material is 1.05: 1. Add ethanol to precipitate to make the alcohol content reach 70%, filter to obtain a precipitate, wash the precipitate with 70% ethanol, dissolve it with an appropriate amount of water, filter, pass the filtrate through a macroporous resin, elute with water, collect the washing liquid, and wash the washing liquid Concentrate to a ratio of 1:2.5 between the volume of the medicinal solution and the medicinal material, add ethanol to make the alcohol content reach 70%, and obtain a precipitate, wash and dehydrate the precipitate with 95% ethanol and acetone, and dry under reduced pressure (60°C) to obtain ...

Embodiment 3

[0216] Example 3 Preparation of Total Astragalus Saponins

[0217] Take Astragalus membranaceus, add water and decoct three times, 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.20-1.25 (60°C), and use ethanol precipitation treatment twice, the alcohol content in the first solution is 75% and 85% for the second time, each time it was placed in cold storage, the ethanol was recovered and concentrated to 10g of the original medicinal material per 1ml, diluted with water for injection to 1g of the original medicinal material per 1ml, placed in cold storage for 12 hours, filtered, The filtrate was concentrated under reduced pressure and dried in vacuo to obtain the obtained product.

[0218] Three batches of total astragalus saponins were prepared respectively, and the results of extract yield and content are shown in Table 6 below.

[0219] Identification 1: Take 0.01g of this product, add methanol 20ml, heat and reflux ...

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Abstract

The present invention discloses a new medicine composition and its preparation method. Said medicine composition is formed from (by weight portion) 100-1600 portions of kurarinone, 500-24000 portions of ganoderma and 1000-80000 portions of astragalus root. Besides, it also can be made up by using 100-1600 portions of kurarinone, 2.5-700 portions of ganoderma polysaccharide and 5-1600 portions of astragalus polysaccharide. Said medicine composition can be made into various dosage forms, can be used for preparing the medicines capable or curing acute and chronic hepatitides and active hepatocirrhosis, etc.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition mainly made of matrine, ganoderma lucidum or its extract, and astragalus or its extract, and a preparation method and application thereof. 【Background technique】 [0002] Hepatitis is a common and frequently-occurring disease. According to incomplete statistics, hepatitis patients and virus carriers account for 10% of the total population in my country. Among them, viral hepatitis is the main one, and viral hepatitis can be divided into: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Chronic hepatitis can be divided into persistent hepatitis and active hepatitis. Hepatitis is a kind of infectious disease, because of its widespread prevalence, great harm, and high incidence rate, it is one of the difficult diseases recognized at home and abroad. Taking hepatitis B as an example, the cure rate is only 10%. Tu...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K31/715A61P1/16A61P31/14A61P31/20A61K31/4375
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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