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235 results about "Oxymatrine" patented technology
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Oxymatrine (matrine oxide, matrine N-oxide, matrine 1-oxide) is one of many quinolizidine alkaloid compounds extracted from the root of Sophora flavescens, a Chinese herb. It is very similar in structure to matrine, which has one less oxygen atom. Oxymatrine has a variety of effects in vitro and in animal models, including protection against apoptosis, tumor and fibrotic tissue development, and inflammation. Furthermore, oxymatrine has been shown to decrease cardiac ischemia (decreased blood perfusion), myocardial injury, arrhythmias (irregular heartbeats), and improve heart failure by increasing cardiac function.
Compositions and methods for treating cellular proliferation disorders
Compositions and methods for treating patients suffering from a proliferation disorder characterized by an increased voltage gated ion-channel uptake are described. Included are compositions comprised of a compound selected from the group consisting of matrine, oxymatrine, artemisinin, agmatine, and vinpocetine.
Owner:NUTRICOLOGY INC
Prepn of matrine, oxymatrine and sophoxidine from flavescent sophora root
The production process features that dried and crushed flavescent sophora root is processed through extraction, concentration, alkalization, reduction, solvent extraction, acid reverse extraction, deposition and separation to produce coarse matrine product and coarse sophoridine product; coarse matrine product and coarse sophoridine product are recrystallized and dried to obtain matrine product and sophoridine product; and matrine is further processed through oxidation with hydrogen peroxide, decompression distillation, crystallization, filtering, re-crystallization and drying to obtain oxymatrine product. The said three products are material for producing medicine for treating hepatitis B, hepatitis C, leucopenia, arrhythmia, cancer and other diseases.The production process of the present invention is simple, low in cost, high in product purity and suitable for industrial production.
Owner:王答祺 +2
Composition of natural herb extract for treating cardiovascular disease and its method of preparation thereof
InactiveUS20060083798A1Reduce risk factorReduce accumulationBiocideAnimal repellantsSide effectAdditive ingredient
A composition of natural herb extract for treating cardiovascular disease or vascular disorder and its method of preparation and separation, and particularly to a composition prepared from natural herb extract comprising constituents of Danshensu, Tanshinone IIA, matrine, oxymatrine and puerarin for lowering the risk factors of heart disease or treating the heart disease that side effects are minimized. The working ranges of Danshensu, Tanshinone IIA, matrine, oxymatrine and puerarin are between 5 and 40 mg / kg per day and a ratio of Danshensu, Tanshinone IIA, matrine, oxymatrine, and puerarin is 1:1:1:1:1. The extraction and separation method of the five active ingredients are also illustrated. The composition can be exhibit in different forms for administration.
Owner:YOUNG JEFFREY
Medicine for treating dermatitis eczema, pruritus due to mosquito bites and use thereof
InactiveCN101361790ARaw materials are non-toxicLow priceHydroxy compound active ingredientsDermatological disorderCnidium monnieriTherapeutic effect
Owner:LOGISTICS UNIV OF CAPF
High-effective mosquito repelling liquid medicine
InactiveCN101700214AAnti-itchAnti-inflammatoryCosmetic preparationsToilet preparationsHypersensitive responseProtection Skin
The invention relates to high-effective mosquito repelling liquid medicine which is characterized by comprising the following components by weight percent: 2%-7% of N, N-Diethyl-m-toluamide, 0.2%-2% of glycyrrhiza extract (0.1%-90% of glycyrrhizinic acid or glycyrrhetinic acid or physiologically acceptable salt thereof), 0.2%-2% of flavescens extract (0%-90% of matrine or oxymatrine or physiologically acceptable salt thereof), 0%-50% of menthol or borneol and 0.01%-2% of plant essential oil. The high-effective mosquito repelling liquid medicine is the hormone-free preparation made of pure Chinese herbal medicine for external application and is prepared by uniquely combining the high-effective repellent with the components having the anti-inflammatory, the antibacterial and the antipruritic effect, thereby being innovative. The high-effective mosquito repelling liquid medicine of the invention has the function of repelling the mosquito, relieving the itching, refreshing the consciousness and protecting the skin from the insect bite and can repel the mosquito for 5-7 hours. The high-effective mosquito repelling liquid medicine of the invention is non-toxic to the skin and mucous membrane, can not cause the allergic reaction and has higher stability.
Owner:TIANJIN HEERBO BIOLOGICAL TECH CO LTD
Combination of medication of containing kurarinone and glycyrrhetic acid, and application
Owner:JIANGSU HENGRUI MEDICINE CO LTD
Insecticide composition containing methylamino Avermectin and matrine
A synergistic composite insecticide contains matrine including oxymatrine, etc and methylamino Avermectin or its salt in the ratio of (0.01-100):1.
Owner:李建中
Nanometer biological environment-friendly multifunctional organic bamboo vinegar medicine fertilizer
ActiveCN103864512AReduce heavy metal contentImprove qualityFertilizer mixturesMonopotassium phosphateBiology
The invention discloses a nanometer biological environment-friendly multifunctional organic bamboo vinegar medicine fertilizer which is prepared by mixing and dissolving the following raw materials: 31-46 parts of bamboo vinegar liquid, 2-16 parts of nano-silicon dioxide, 1-2 parts of monopotassium phosphate, 0.2-0.3 part of penshibao (a brand) leaf fertilizer, 0.6-0.8 part of toosendanin, 0.6-0.8 part of radix aconite agrestis extract, 0.6-0.8 part of oxymatrine, 0.3-0.6 part of soapnut saponin, 0.2-0.6 part of rheum officinale anthraquinone, 0.15-0.16 part of natural pyrethrin essential oil, 2-4 parts of extract of opuntia and a proper amount of water. The bamboo vinegar medicine fertilizer disclosed by the invention can be used as a soil conditioner to adsorb the heavy metal in the soil and reduce the heavy metal content in the crops, thereby improving the quality of the crops.
Owner:桂林市宏田生化有限责任公司
Process for producing high purity matrine oxide by kuh-seng
InactiveCN1793142ADoes not damage the structureReduce extraction timeOrganic chemistryDistillationSolvent
The invention relates to a method to make oxymatrine from kuhseng that includes the following steps: mixing kuhseng raw material with alcohol acid solution or alkali solution, taking sonic oscillation, concentrating the distilled liquid, separating flavonoid material, adjusting pH value to below 3, degreasing by non-polar solvent; adjusting the pH value to over 11, extracting by organic solvent, adding crystal solvent to dissolve, decoloring, crystallizing, solving by alcohol or methanol adding catalyst to take reaction, filtering to gain raw oxymatrine, adding to crystal solvent to take recrystallizing to gain oxymatrine. The invention simplifies separating process, decreases cost and realizes high purity oxymatrine distillation.
Owner:SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
Microwave-assisted aqueous two-phase/reversed micelles extraction method of Sophora flavescens alkaloids
The invention discloses a microwave-assisted aqueous two-phase / reversed micelles extraction method of Sophora flavescens alkaloids. The method comprises the steps of extracting Radix Sophorae Flavescentis or Radix Sophorae Tonkinensis by use of microwave-assisted ethanol-ammonium sulfate aqueous two-phase system, in which Sophora flavescens alkaloids are partitioned between the two aqueous phases and extracted into the upper phase to complete primary purification; selectively extracting Sophora flavescens alkaloids by use of SDBS (sodium dodecyl benzene sulfonate) / isooctane / n-octanol reversed micelles system, to obtain Sophora flavescens alkaloids crude product with low impurity content; and performing separation and purification to obtain matrine, oxymatrine and sophoridine. The method combines reversed micelles extraction, microwave-assisted extraction and aqueous two-phase extraction technologies, to realize advantage complementation, simple method, high speed and efficiency, no pollution, low requirements for facilities, easy continuous production and scale-up. The extracted Sophora flavescens alkaloids have purity above 90.92% and yield up to 55.38 mg / g. The separated and purified matrine, oxymatrine and sophoridine have high purity above 94% and little organic solvent residue.
Owner:GUANGDONG PHARMA UNIV
Ointment for treating acnes
InactiveCN102764256AGood treatment effectEasy to useHydroxy compound active ingredientsAerosol deliveryTherapeutic effectPollution
The invention relates to ointment for treating acnes. The ointment is prepared by mixing the following components in percentage by mass: 3 percent of oxymatrine, 1 percent of vitamin E, 2 percent of azelaic acid, 0.5 percent of menthol, 5 percent of 2901, 3 percent of boric acid, 2 percent of azone and 83.5 percent of cream base. The ointment is smeared on and infiltrates parts with the acnes, has the effects of diminishing inflammation and promoting blood circulation in blood capillaries, has remarkable treatment effects, is convenient to use and pollution-free, and is suitable to be used as a medicament for treating the acnes.
Owner:中国船舶集团渤海造船有限公司
Oxymatrine hepatic targeting nano drug delivery system and preparation method thereof
ActiveCN102961360AReduce intakeSpeed up entryOrganic active ingredientsDigestive systemPolyethylene glycolEvaporation
The invention relates to an oxymatrine hepatic targeting nano drug delivery system and a preparation method thereof. The oxymatrine hepatic targeting nano drug delivery system is prepared by the following steps of: with polyethylene glycol-polycaprolactone block polymer as a carrier, preparing polymer nanoparticles by adopting a film dispersion method, a reverse evaporation method or an organic solvent injection method, encapsulating oxymatrine into the polymer nanoparticles, then modifying a new glycoprotein or cyclic octapeptide ligand to be taken as a ligand on the surfaces of the nanoparticles, and constructing an anti-hepatic fibrosis nano targeting drug delivery system for hepatic stellate cells (HSCs). The nano drug delivery system has the advantages that particle size is 50-260nm, encapsulation efficiency is 18-42%, drug loading capacity is 2-12% and the surface of the nano drug delivery system is rich in new glycoprotein M6PHSA (mannose-6-phosphate human serum albumin) or cyclic octapeptide RGD (arg gly asp). The oxymatrine hepatic targeting nano drug delivery system provided by the invention can increase opportunities that nanoparticles enter the liver through blood circulation, is beneficial to targeting distribution of drugs at focus parts of the liver and is beneficial to absorption of drug-carrying nanoparticles at lesion parts of the liver and ingestion of HSCs, so that hepatic fibrosis treatment is enhanced.
Owner:NINGXIA MEDICAL UNIV
Traditional Chinese medicine composition for improving immunity and resisting viruses for livestock and poultry, as well as preparation method and application thereof
InactiveCN106309464ASimple recipeEasy to administerAnthropod material medical ingredientsHydroxy compound active ingredientsDiseaseChlorogenic acid
The invention relates to a traditional Chinese medicine composition for improving immunity and resisting viruses for livestock and poultry, as well as a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 0.5-3 parts of baicalin, 0.2-1.6 parts of oxymatrine, 0.1-1 part of chlorogenic acid, 0.5-2 parts of epigoitrin, 0.1-2 parts of berberine, 0.5-1.5 parts of gallic acid and 1.5-5 parts of astragalus polysaccharide. The traditional Chinese medicine composition is used for directly or indirectly killing viruses by the active components of natural herbs, can get rid of antibiotics in the feeding process, and has excellent effects for treating and preventing chicken new castle disease viruses, hog cholera viruses and the like.
Owner:CHANGSHA BROAD OCEAN BIO SCI & TECHN CO LTD
Method for preparing axcnic high pure oxymatrine
InactiveCN1687063AMaximizeReduce consumptionOrganic chemistryBulk chemical productionOxymatrineSophora Root
The present invention relates to a method for preparing sterile high-purity oxymatrine. Said method uses dried flavescent sophora root as raw material and adopts the following main procedures: pulverizing, continuous counter-current extraction, alkaline solution extraction, supercritical Co2 extraction, centrifugal separation, concentrating and drying, pH regulation and reduced pressure distillation, etc. to prepare the invented product. Said invention also provides the concrete steps of the above-mentioned every procedure and whole preparation process.
Owner:黑龙江麦迪欣澳逸医药技术咨询有限公司
Preparation process of high-purity oxymatrine
The invention provides a preparation process of high-purity oxymatrine. The method comprises the following steps of: firstly, heating purified water in a water bath to a certain temperature; adding hydrogen peroxide and slowly adding oxymatrine to react at the certain temperature until the hydrogen peroxide is completely consumed; then, extracting residual less oxymatrine; decompressing and concentrating a reaction solution and adding an alcohols substance into the concentrated solution to be dissolved; adding a de-coloring agent for decoloring and filtering; continually decompressing and concentrating; adding an acetones substance to crystallize; and re-crystallizing to obtain the oxymatrine. The process method disclosed by the invention has the advantages of simplicity and practical applicability, low cost and high yield; and more importantly, the purity is high and the preparation process is suitable for industrial production.
Owner:NINGXIA BAUHINIA PHARMA
Process for producing high purity matrine oxide
InactiveCN1793143AEase of industrial productionReduce manufacturing costOrganic chemistryOxymatrinePtru catalyst
The invention relates to a method to make high purity oxymatrine that includes the following steps: mixing kuhseng or fenugreek raw material with acid solution , taking sonic oscillation, filtering, adjusting pH value to below 3, degreasing by non-polar solvent; adjusting the pH value to over 11, extracting by organic solvent, adding crystal solvent to dissolve, decoloring, crystallizing, solving by alcohol or methanol adding catalyst to take hydrogenation reaction, hydrogen peroxide oxidation to gain raw oxymatrine, adding to crystal solvent to take recrystallizing to gain oxymatrine. The invention simplifies separating process, decreases cost and realizes high purity oxymatrine distillation.
Owner:SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
Quality control method for medicament composition for treating knubble
The invention discloses a quality control method of a drug compound pharmaceutical preparation for treating tumors. The drug compound pharmaceutical preparation is prepared by the flowing ingredients according to the weight proportion: 200 to 400 shares of milk veteh, 60 to 130 shares of ginseng and 6 to 13 shares of oxymatrine. The quality control method of the drug compound pharmaceutical preparation consists of a method of authentication and / or content measurement for the preparation and also a fingerprint quality control method of the finished preparation product and the intermediate product. The quality control method of the drug compound pharmaceutical preparation for treating tumors adopts a specific method to treat the provided testing solution or adopts specific filling agents and moving phases to make the final result of data more precise, thereby controlling the quality of the drug compound pharmaceutical preparation effectively.
Owner:CHANGBAISHAN PHARMA
Medicinal composition of astragalus, salvia miltrorrhiza and oxymatrine, and its preparing method
InactiveCN1977889AMeet clinical needsSignificant effectOrganic active ingredientsDigestive systemAlcoholic hepatitisViral hepatitis
The present invention discloses a new medicine composition for curing hepatic diseases and its preparation method. It is formed from (by weight portion) 400-10000 portions of astragalus root, 200-6000 portions of salvia root and 10-200 portions of kurarinone, and also can be made up by using 2-200 portions of astragalus total saponin or astragalus polysaccharide, 2-200 portions of salvia total phenolic acid and 10-200 portions of kurarinone. Said medicine composition can be made into various dosage forms of oral preparation, injection and others. Said medicine composition can be used for curing diseases of viral hepatitis, medicamentous liver lesion, fatty liver and alcoholic hepatitis, etc.
Owner:海安江理工技术转移中心有限公司
Pesticidal formulation containing oxymatrine or matrine
Compositions and methods are provided for a water-soluble insecticidal or pesticidal comprising at least one alkaloid, particularly at least one tetracyclo-quinolizindine alkaloid derived from sophora roots, particularly matrine and / or oxymatrine.
Owner:MARRONE BIO INNOVATIONS
Anti-mite handmade soap with natural source and preparation method thereof
InactiveCN106822725AEnsure normal breathingImprove immunitySoap detergents with organic compounding agentsHydroxy compound active ingredientsOxymatrineNatural source
The invention discloses an anti-mite handmade soap. The formula of the anti-mite handmade soap comprises a soap base and an anti-mite compound, wherein the anti-mite compound comprises the following components in parts by weight: 0.1-2 parts of oxymatrine, 0.1-1 part of 4-terpineol and 0.1-2 parts of borneol. The anti-mite handmade soap can achieve the effects of thoroughly cleaning, killing vermiform mite and repairing skin and has the characteristics of fast effectiveness, no toxic side effect, strong affinity with skin, safety, comfort and no irritation.
Owner:广东创美抗衰老研究有限公司
Compositions for Improving Skin Conditions Comprising Matrine or Its Oxidized Derivatives
InactiveUS20100099698A1Increase collagen synthesisInhibited collagenase activityCosmetic preparationsBiocideSide effectVitamin A Retinol
The present invention relates to a composition for improving skin conditions comprising matrine and oxymatrine as an active ingredient. Matrine and oxymatrine have lower cytotoxicity than retinol used as anti-wrinkle agents and exhibit the inhibition effect on collagenase activity and promotion effect on collagen biosynthesis at a molecular level, contributing to excellent efficacy in improvement of skin wrinkles. In addition, both matrine and oxymatrine exhibit the inhibition effect on melanin production by inhibiting intracellular tyrosinase activity, the improving effects of UV-induced skin damage and the skin growth promotion or hair loss prevention. Therefore, matrine and oxymatrine have the excellent improvement effects on skin conditions. Furthermore, matrine and oxymatrine have the excellent anti-obesity and anti-oxidation effects. The composition of this invention can be applied to cosmetic, pharmaceutical and food composition having no cytotoxicities and side effects.
Owner:BIOSPECTRUM
Grape special-purposed botanical pesticide
The invention discloses a grape special-purposed botanical pesticide composed of the raw materials of, by weight, 5-8 parts of a veratrine solution, 4-6 parts of oxymatrine, 9-12 parts of toosendanin, 10-13 parts of nicotine, 11-14 parts of double-element alkali, 7-10 parts of derris root, and 6-10 parts of pyrethrin. Compared to chemical pesticides, because of the difference in action mechanisms, the product provided by the invention has the advantages of low toxicity, low residue, no environmental pollution, and low influence on grape quality. With the pesticide, grape price and quality are both good, such that the economic benefit is significant.
Owner:唐兴龙
Sophocarpidine, oxymatrine glycyrrhetinic acid double salt, and preparation method and use thereof
InactiveCN103130865AImprove acid polarityEasy to operateAntibacterial agentsOrganic active ingredientsSophocarpidineOxymatrine
The invention relates to a compound of sophocarpidine and glycyrrhetinic acid double salt, a compound of oxymatrine glycyrrhetinic acid double salt, and a composition, a preparation method and use thereof, and particularly relates to the use of two double salts in the treatment of inflammation, bacterial infected skin diseases and allergic dermatitis. The polarity of the glycyrrhetinic acid, easy oxidation of sophocarpidine, and strong moisture adsorption of oxymatrine are well improved by the sophocarpidine glycyrrhetinic acid double salt; the preparation method is simple and easy to operate, and is high in yield; meanwhile, a good synergistic effect is displayed in anti-inflammation and antibiosis; and the dosage is obviously reduced.
Owner:TIANJIN HEERBO BIOLOGICAL TECH CO LTD
Medicinal composition containing realgar
ActiveCN102119958ALow toxicityImprove anti-tumor effectOrganic active ingredientsInorganic active ingredientsOxymatrineGINSENG EXTRACT
The invention provides a medicinal composition containing realgar. Particularly, the medicinal composition contains realgar microbiological leaching liquid, a ginseng extract, an astragalus extract and oxymatrine. An animal experiment shows that the medicinal composition has an obvious down-regulation effect on excessive activation of a path of a proto-oncogene Ras and low toxicity; therefore, the medicinal composition is suitable to be applied in the preparation of an antineoplastic medicine.
Owner:李红玉
Synergy composition for matrine and tetronic acid pesticides
InactiveCN102484996AReduce the dose of the active ingredientLow costBiocideAnimal repellantsVerminSpirotetramat
The invention belongs to the pesticide technology field, and relates to a synergy composition for matrine and tetronic acid pesticides. The mass ratio of matrine to tetronic acid is 50:1-1:50. The matrine in the composition comprises matrine, oxymatrine and a mixture of matrine and oxymatrine, or a series alkaloid extract and its preparation obtained from plants such as radix sophorae flavescentis, Sophora alopecuroides and Subprostrate Sophora Root. The tetronic acid pesticide can be one of spirotetramat, spirodiclofen and spirotetramat or its combination. The composition of the invention is capable of generating cooperation and synergy effects, overcoming harmful biological drug resistance, prolonging the service life of the pesticide, and enlarging the prevention and cure scope, can be used for preventing and treating a plurality of insect diseases on agriculture and gardening crops, especially suitable for insects possessing drug resistance on single pesticide, such as aphid, scale insect, leaf mites, leafhopper, planthopper or whitefly and thrips.
Owner:SOUTH CHINA AGRI UNIV
Composition of natural herb extract for treating cardiovascular disease and its method of preparation thereof
InactiveUS7384657B2Reduce risk factorReduce accumulationBiocideAnimal repellantsSide effectAdditive ingredient
Owner:YOUNG JEFFREY
Oxymatrine or matrine sustained-release pellet and preparation method thereof
InactiveCN101176724AGood treatment effectReduce toxic and side effectsOrganic active ingredientsAntipyreticSustained release pelletsSide effect
The invention discloses an oxymatrine sustained-release pellet, a matrine sustained-release pellet and a preparation method of the sustained-release pellets, belonging to the medicine technical field. The invention is characterized in that: the sustained-release preparation mainly comprises a oxymatrine or a matrine, a blank pill core, a coating material, a surface-active material, a hydroxypropyl methylcellulose, an antisticking agent and a plasticizing agent; the weight ratios are 10 to 70 percent for the oxymatrine or the matrine, 20 to 85 percent for the blank pill core, 2 to 20 percent for the coating material, 0.01 to 1 percent for the surface-active material, 1 to 3 percent for the adhesive, 1 to 5 percent for the antisticking agent and 0 to 1.5 percent for the plasticizing agent. The invention is reposefully released in different medium from the experiment results in vitro, and has the advantages of smooth blood concentration of drug in vivo, small side effect, few medication time and long duration of drug effect.
Owner:SHENYANG PHARMA UNIVERSITY
Taste-type bird and mouse repellent composition
InactiveCN102792975ARepelling is effectiveTo achieve the repellent effectBiocidePest repellentsAstragalosideBerberine
The invention relates to bird and mouse repellent technologies, specifically to a taste-type bird and mouse repellent composition. The composition comprises the following components by weight: 10-60% of methyl anthranilate; 0.05-0.08% of berberine; 0.05-0.08% of astragaloside; 0.25-0.55% of Oxymatrine and / or 0.25-0.55% of capsaicin; 0.35-0.6% of mustard oil and / or 0.5-1.2% of zanthoxylum oil; and the balance water as well as additives. Under the premise of not harming bird and mouse health, the invention achieves the repellent effect. Therefore, the repellent composition studied by the invention can effectively repel birds and mice and is environment-friendly, thus being a safe and harmless type repellent product in a real sense. The product prepared by the invention can be widely applied to seed dressing, seedling spraying, mature fruit spraying and the like in agricultural production.
Owner:ANHUI JUDI AGRI TECH
Alkaloids sophora flavescen pellicle and its preparation process
InactiveCN1593408AAnti-allergicAnti-inflammatoryOrganic active ingredientsSexual disorderWater bathsAlkaloid
Disclosed is a alkaloids sophora flavescen pellicle and its preparation process, wherein the pellicle comprises matrine and oxymatrine as the active constituents, and added anti-oxidant and fill forming material. The preparation process includes, steeping the film forming material with water, dissolving by water-bath, dissolving the matrine and total matrines with the mixed solution of water and ethanol, mixing with the aqueous solution of the film forming material, adding anti-oxidant simultaneously, mixing, removing air bubbles, coating into film and drying.
Owner:贵阳高新瑞得科技开发有限公司
Process for extracting oxymatrine and matrine from sophora moocroftiana
This invention relates to a technology that extracts ammothamnine and matrine from Tibet sandliving sophora seed. Seeds or branch of sandliving sophora seed are shattered. Through ethanol water bath reflux extracting, concentration, acidification, filtration, defatting, alkalization, organic solvent extraction, reclaiming solvent, total alkali of sandliving sophora seed is obtained; Total alkali is dissolved by using acetone, precipitated by using diethyl ether.
Owner:INST OF GEOGRAPHICAL SCI & NATURAL RESOURCE RES CAS
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