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Medicine composition of red sage and rhodiola root

A technology of rhodiola rosea, medicine, applied in the field of medicine

Inactive Publication Date: 2007-03-21
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Utilize the interaction of red ginseng and rhodiola rosea, and combine prescriptions to prepare medicines for treating cardiovascular and cerebrovascular diseases, etc., which have not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0169] The preparation of embodiment 1 salvia miltiorrhiza

[0170] Take Danshen medicinal material, crush it into coarse powder, add water to decoct twice, add 12 times the amount of water for the first time, add 10 times the amount of water for the second time, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to relative density 1.08-1.12 concentrated solution, add ethanol until the alcohol content reaches 85%, refrigerate for 24 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add hydrochloric acid to adjust the pH value to 2, shake and extract with ethyl acetate three times, The combined ethyl acetate solutions were evaporated to dryness. The residue was dissolved in acidic water with a pH value of 2, added to the treated polyamide column, first eluted with 2 times the column volume of water, discarded the water washing solution, and then eluted with 4 times the column volume of 95%...

Embodiment 2

[0181] Example 2 Preparation of Rhodiola Rosea Extract

[0182] 1. Preparation process

[0183] (1) Preparation of Rhodiola rosea total phenols

[0184] Take Rhodiola rosea medicinal material, crush it into coarse powder, extract three times with 70% ethanol for 1 hour each time, add 10 times the amount of alcohol for the first time, and 8 and 8 times the amount for the second and third times respectively. Filtrate, combine the extracts, recover ethanol until every 5ml contains 1g raw medicinal materials, degrease with 2 times the amount of petroleum ether, discard the petroleum ether liquid, then extract with n-butanol saturated with water, concentrate under reduced pressure to a thick paste, spray Dried to obtain the rhodiola rosea extract.

[0185] If necessary, it can be further refined. After dissolving the Rhodiola rosea extract obtained above with an appropriate amount of water, add it to the macroporous resin column that has been treated in advance, and then use water ...

Embodiment 3

[0214] Embodiment 3 Preparation of the composition aqueous injection of the present invention

[0215] 1. Prescription:

[0216] Prescription 1:

[0217] Salvia miltiorrhiza extract 100.0g (equivalent to 5kg of the original medicinal material)

[0218] Rhodiola rosea extract 30.1g (equivalent to 1kg of raw material)

[0219] Add water for injection to 5000ml

[0220] A total of 1000 sticks were prepared

[0221] Prescription 2:

[0222] Danshen 5kg

[0223] Rhodiola rosea 1kg

[0224] Add water for injection to 5000ml

[0225] A total of 1000 sticks were prepared

[0226] Prescription 3:

[0227] Danshen 10kg

[0228] Rhodiola rosea 25g

[0229] Add water for injection to 5000ml

[0230] A total of 1000 sticks were prepared

[0231] Prescription 4:

[0232] Danshen 1kg

[0233] Rhodiola rosea 3kg

[0234] Add water for injection to 5000ml

[0235] A total of 1000 sticks were prepared

[0236] Prescription 5:

[0237] Danshen 7.5kg

[0238] Rhodiola rosea 1....

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparation process. The medicine composition is prepared with red sage in 100-1000 weight portions and rhodiola root in 25-300 weight portions, and may be also prepared with red sage extract and rhodiola root extract in the weight ratio of 1 to 0.01-20. The medicine composition may be prepared into different pharmaceutically acceptable forms, such as injection and orally taken preparation. The medicine composition has synergistic pharmaceutical effects of antagonizing platelet aggregation, resisting thrombosis, improving myocardial blood supply, etc and may be used in treating coronary heart disease, myocardial infarction, ischemic cerebral vascular diseases, etc.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicines, and relates to a pharmaceutical composition made of salvia miltiorrhiza and rhodiola rosea or an extract of salvia miltiorrhiza and rhodiola rosea, a preparation containing the medicinal composition and a preparation method thereof. 【Background technique】 [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, there are more than 3 million people who die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of people lost their ability to work to varying degrees, and 4% were seriously disabled. In particular, the age of its onset and death is increasingly younger, and how to effectively prevent and treat it has attracted people's attention. [0003] Cardiovascular and cerebrovascular ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 蔡军
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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