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Medication composition of acetyl cysteine or its pharmaceutical salt and asarin

A technology of acetylcysteine ​​and composition, applied in the field of medicine, to achieve the effects of increased immunopositive intensity of Clara cells, increased relative gray scale, and uniform and stable drug quality

Inactive Publication Date: 2007-10-10
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, using the interaction between acetylcysteine ​​or its pharmaceutically acceptable salt and asarone, the compatibility formula is used for the treatment of pneumonia, bronchial asthma, chronic obstructive pulmonary disease, and acute inflammation of the lungs. , not yet reported

Method used

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  • Medication composition of acetyl cysteine or its pharmaceutical salt and asarin
  • Medication composition of acetyl cysteine or its pharmaceutical salt and asarin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] The preparation of embodiment 1 etaminoxine composition powder injection

[0080] 1. Prescription:

[0081] Prescription of etaminoxine composition 1

[0082] Acetylcysteine ​​100g

[0083] Asarum 16g

[0084] Polysorbate 80 80g

[0085] Mannitol 300g

[0086] Add sterile water for injection to 3000ml

[0087] A total of 1000 sticks were prepared

[0088] Prescription of etaminoxine composition 2

[0089] Acetylcysteine ​​200g

[0090] Asarum 24g

[0091] Polysorbate 80 120g

[0092] Mannitol 500g

[0093] Add sterile water for injection to 5000ml

[0094] A total of 1000 sticks were prepared

[0095] 2. Specific steps:

[0096] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0097] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity.

[0098] 3) Take sterile water for injection with a dosing volume of 80%, add mannitol and polysorbate 80, heat ...

Embodiment 2

[0106] Example 2 Preparation of Ethaminosarcoma Composition Aqueous Injection

[0107] 1. Prescription:

[0108] Prescription of etaminoxine composition 1

[0109] Acetylcysteine ​​100g

[0110] Asarum 16g

[0111] Ethanol 100ml

[0112] Macrogol 400 100ml

[0113] Add water for injection to 5000ml

[0114] A total of 1000 sticks were prepared

[0115] Prescription of etaminoxine composition 2

[0116] Acetylcysteine ​​300g

[0117] Asarum 60g

[0118] Ethanol 200ml

[0119] Macrogol 400 200ml

[0120] Add water for injection to 10000ml

[0121] A total of 1000 sticks were prepared

[0122] 2. Specific steps:

[0123] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0124] 2) Take the prescribed amount of ethanol and add an equal amount of water to mix, dissolve asarone, add 40% water for injection and polyethylene glycol 400 to dissolve acetylcysteine, mix the two, ad...

Embodiment 3

[0133] Example 3 Preparation of Ethaxarin Composition Sodium Chloride Infusion

[0134] 1. Prescription:

[0135] Prescription of etaminoxine composition 1

[0136] Acetylcysteine ​​100g

[0137] Asarum 16g

[0138] Polysorbate 80 100g

[0139] Sodium chloride 900g

[0140] Add water for injection to 100000ml

[0141] A total of 1000 bottles were prepared

[0142] Prescription of etaminoxine composition 2

[0143] Acetylcysteine ​​250g

[0144] Asarum 40g

[0145] Polysorbate 80 200g

[0146] Sodium chloride 2250g

[0147] Add water for injection to 250000ml

[0148] A total of 1000 bottles were prepared

[0149] 2. Specific steps:

[0150] 1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh water for injection before use.

[0151] 2) Polysorbate 80 is made into a 20% solution with water for injection, acetylcysteine ​​and asarone are added, heated and stirred to dissolve completely, and sodium chloride is ...

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Abstract

A medical composition used to prepare the medicines for treating pneumonia, bronchial asthma, chronic obstructive pneumonia, and acute inflammation of lung is composed of acetylcysteine or its pharmacologically acceptable salt (20-1200 Wt. portions) and asarone (1-200). Its preparing process is also disclosed.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of acetylcysteine ​​or a pharmaceutically acceptable salt thereof and asarone, a preparation method and application thereof, and belongs to the technical field of medicine. 2. Background technology [0002] In my country's population statistics, respiratory diseases are the second cause of death, mainly including upper respiratory tract infection, acute and chronic bronchitis, pneumonia, etc. The main symptoms are cough, sputum, and asthma. Most are caused by viral infection first, and a few are caused by direct bacterial infection. However, there are not many available drugs in clinical practice and their effects are slow. [0003] Acetylcysteine, which is N-acetyl-L-cysteine. Acetylcysteine ​​is a mucolytic agent, which has a strong effect of dissolving mucus. Viscosity of sputum and liquefaction. Acetylcysteine ​​can also break DNA fibers in purulent sputum, so it can not only d...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K9/12A61P11/00A61K31/09
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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