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Compound traditional Chinese medicine preparation for treating heart disease

A technology of compound traditional Chinese medicine and heart disease, which is applied in the field of medicine to achieve wide application prospects, reduce the relative dosage of drugs, and achieve the effect of definite curative effect

Active Publication Date: 2014-07-09
赵宪斌 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, using the interaction of hawthorn leaves, scallions, and Polygonatum, the compatible prescriptions are used to treat cardiovascular and cerebrovascular diseases, and there is no report yet

Method used

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  • Compound traditional Chinese medicine preparation for treating heart disease
  • Compound traditional Chinese medicine preparation for treating heart disease
  • Compound traditional Chinese medicine preparation for treating heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: the preparation of hawthorn leaf extract

[0039] Take 7 parts of hawthorn leaves, soak for 2 hours in 45% ethanol which is 8 times of the total weight of the materials for the first time, extract for 2 hours at 80°C, and use 45% of 5 times the total weight of the materials for the second time Extract with ethanol for 1 hour at 80°C, extract for the third time with 45% ethanol at 80°C for the third time, and extract with 45% ethanol at 80°C for the fourth time The extracts were extracted for 0.5 hours, the extracts were combined, and ethanol was recovered by distillation. The distillate was centrifuged at a speed of 3000 R per minute for 30 minutes, and the precipitate was washed three times with purified water twice the volume of the total weight of the materials, and the supernatant after centrifugation was combined. And wash the precipitated supernatant, distill and concentrate to nearly dryness, then dry, pulverize, and obtain.

[0040] Identification...

Embodiment 2

[0053] Embodiment 2: the preparation of Radix Allium, Rhizoma Polygonatum Extract

[0054] Weigh 3.5 parts of Allium and 1.5 parts of Polygonatum, add 10 times the amount of water to decoct for 2 hours at 100°C for the first time, add 8 times the amount of water for the second time and decoct for 1 hour, combine the decoctions, and concentrate the filtrate to 1: 1. Add ethanol to make the alcohol content to 55%, centrifuge, take the supernatant, filter, distill to recover ethanol, continue to distill and concentrate to an appropriate amount, dry, pulverize, and obtain.

[0055] Determination of the content of the extracts of Allium scallion and Polygonatum

[0056] Preparation of Reference Substance Solution Take 33 mg of anhydrous glucose reference substance dried at 105°C to constant weight, accurately weigh it, put it in a 100ml measuring bottle, add water to dissolve and dilute to the mark, shake well to obtain (every 1ml contains anhydrous glucose 0.33 mg).

[0057] Pre...

Embodiment 3

[0061] Embodiment 3: the preparation of composition tablet

[0062] prescription

[0063]

[0064] Preparation method: extract hawthorn leaves according to the method in Example 1 to obtain the hawthorn leaf extract; extract allium and Polygonatum according to Example 2 to obtain the extracts of Allium and Polygonatum. Weigh the extract and the auxiliary materials of the prescribed amount, pulverize, pass through a 100-mesh sieve respectively, and set aside. Mix hawthorn leaf extract, scallion extract, sealwort extract, starch, pregelatinized starch, and microcrystalline cellulose evenly, and stir evenly to make a suitable soft material. Sieve through 18 mesh to make granules. The granules were dried at 60°C. Add sodium carboxymethyl starch and magnesium stearate to the dried granules, pass through a 18-mesh sieve for granulation, and mix well. Sampling, testing of semi-finished products. Press the tablet according to the tablet weight determined by the assay. Finishe...

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Abstract

In order to meet the clinical needs, better treat cardiovascular and cerebrovascular diseases and improve the health level of the people, the invention provides a new pharmaceutical composition for the treatment of the cardiovascular and cerebrovascular diseases and its preparation method, and the pharmaceutical composition is mainly prepared from hawthorn leaves, allium macrostemon, polygonatum and rhizoma polygonati, and produces previously unimagined effects on the treatment of the cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation of a pharmaceutical composition mainly made of hawthorn leaves, scallions and sealwort for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular disease, also known as circulatory system disease, is a series of diseases involving the circulatory system. The circulatory system refers to the organs and tissues that transport blood in the human body, mainly including the heart and blood vessels (arteries, veins, microvessels), which can be subdivided into acute and chronic, and are generally related to arteriosclerosis. [0003] Cardiovascular disease is a common disease that seriously threatens the health of human beings, especially middle-aged and elderly people over 50 years old. With the improvement of living standards and changes in the rhythm of life, the "three highs" (ie, high Blood p...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P9/00
Inventor 赵宪斌肖延斌
Owner 赵宪斌
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