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Medicine composition of glycyrrhizic acid or its salt, ginseng and glossy ganoderma

Technology of a composition, glycyrrhizic acid, applied in the field of medicine

Inactive Publication Date: 2007-06-27
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the interaction of glycyrrhizic acid or its pharmaceutically acceptable salt, ginseng or its extracts, and ganoderma lucidum or its extracts, compatible prescriptions, and drugs for the treatment of hepatitis have not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Example 1 Preparation of ginseng extract with polysaccharide as the main active ingredient, i.e. ginseng polysaccharide

[0144] Ginseng polysaccharide preparation process:

[0145] Take ginseng, chop it up, extract it with 75% ethanol, reflux for 4 hours, filter, dry the dregs, add water to decoct five times, combine the decoction liquid, add 0.3% activated carbon, stir for 30 minutes, stand overnight, filter , the filtrate was passed through a resin column, the effluent was collected, concentrated under reduced pressure, added ethanol to make the alcohol content reach 95%, refrigerated, filtered, the precipitate was washed with acetone, the acetone was drained, the precipitate was taken out and dried at 60-80°C, crushed have to.

[0146] Ginseng Polysaccharide Identification Experiment

[0147] (1) Take about 0.2g of this product, add 5ml of water to dissolve, add 5 drops of alkaline copper tartrate test solution, heat to produce a red precipitate, cool, filter, t...

Embodiment 2

[0156] Example 2 Preparation of ginseng extract with total saponins as the main active ingredient, i.e. total ginsenosides

[0157] Preparation process of total ginseng saponins:

[0158] Take the ginseng medicinal material, crush it into fine particles, and extract twice with ethanol under reflux, each time for 3 hours, add 10 times the amount of alcohol each time, combine the extracts, refrigerate, filter, recover the ethanol from the filtrate and concentrate it to a thick paste, add water to an appropriate amount ( Make each 1ml equivalent to 1g of the original medicinal material), stir well, refrigerate, filter, add the filtrate to the processed macroporous resin column, first elute with 2V ~ 3V column volume of water, discard the washing solution, and then Elute with 3 times column volume of 80% ethanol, collect the eluate, recover the ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.30-1.35, and dry it in vacuum to obtain the pr...

Embodiment 3

[0173] Example 3 Preparation of Ganoderma lucidum extract with polysaccharide as the main active ingredient, i.e. Ganoderma lucidum polysaccharide

[0174] Preparation technology of Ganoderma lucidum polysaccharide

[0175] Take Ganoderma lucidum, crush it into coarse grains, add 3 times the amount of water to moisten overnight, decoct three times the next day, add 12 times the amount of water for the first 3 hours, add 10 times the amount of water for the second 2 hours, add 10 times the amount of water for the third 1 hour Double the amount, combine the decoction, filter, concentrate the filtrate to a relative density of 1.02-1.06, let it cool, add ethanol to make the alcohol content 65%, stir well, place it at 4°C for 24 hours, filter, and recover the ethanol from the filtrate to No alcohol smell, filter, add ethanol to make the alcohol content 80%, stir well, place at 4°C for 24 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, place at ...

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is especially one medicine composition for treating hepatitis and its preparation process and use. The medicine composition consists of glycyrrhizic acid or its pharmaceutically acceptable salt 4-800 weight portions, ginseng 250-16000 weight portions, and glossy ganoderma 500- 20000 weight portions. It may consist of glycyrrhizic acid or its pharmaceutically acceptable salt, the extract of ginseng and the extract of glossy ganoderma. It may be prepared into different forms. The medicine composition has the synergistic effect of the components, high stability, high effect and wide application.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of glycyrrhizic acid or its pharmaceutically acceptable salt, ginseng or its extract and ganoderma lucidum or its extract and a preparation method thereof, belonging to the technical field of medicine. 2. Background technology [0002] Hepatitis is one of the common serious infectious diseases, among which viral hepatitis is the main one. According to incomplete statistics, currently 8-10% of the Chinese population are carriers of hepatitis B virus, and there are still a considerable number of new patients increasing every year. Viral hepatitis can be divided into types: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Hepatic fibrosis refers to the pathological process of abnormal hyperplasia of fibrous connective tissue in the liver when liver cells undergo necrosis and inflammatory stimulation. In mild cases, it is called liver fibrosis. Cirrhosis of th...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P1/16A61P31/14A61P31/20A61K31/704
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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