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Medicinal composition for treating diabetes chronic complication and preparation method of effective component

A technology for diabetes and complications, applied in the field of preparation of rhubarb total free anthraquinones

Inactive Publication Date: 2007-08-15
SICHUAN INST OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Diabetes can lead to a variety of chronic complications that seriously affect human health. The contents of the above literature are mostly researches and reports on kidney diseases.

Method used

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  • Medicinal composition for treating diabetes chronic complication and preparation method of effective component
  • Medicinal composition for treating diabetes chronic complication and preparation method of effective component
  • Medicinal composition for treating diabetes chronic complication and preparation method of effective component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 5 kg of rhubarb medicinal material, crushed, added 6 times the amount of 80% ethanol, heated and refluxed for 3 times, 1 hour each time, filtered, combined the extracts, recovered the solvent, and obtained an extract equivalent to about 2.5 g rhubarb / ml. Add 200ml of concentrated hydrochloric acid while stirring, hydrolyze at 60°C for 5 hours, cool, filter, and wash with water to pH 5-6 to obtain a precipitate. The precipitate was pulverized, added to 50% ethanol solution containing 5% sodium hydroxide, fully stirred to dissolve, and filtered to obtain an alkali-alcohol solution. Add hydrochloric acid to acidify to pH 1-2, produce precipitate, leave overnight, filter, wash with 80% ethanol, dry, obtain rhubarb extract containing total free anthraquinones. Carry out chemical composition analysis and determine the content of total free anthraquinone according to the above method, the main components are anthraquinone derivatives such as rhein, emodin, chrysophanol, emodin...

Embodiment 2

[0041] Rhubarb medicinal material 5kg, cut into slices, add 10 times the amount of water, decoct twice for 0.5 hours each time, filter, combine the extracts, concentrate, and obtain an extract equivalent to about 1.5g rhubarb / ml. Add 150ml of concentrated sulfuric acid while stirring, hydrolyze at 80°C for 3 hours, cool, filter, and wash with water until pH 5-6 to obtain a precipitate. The precipitate is pulverized, added to 70% ethanol solution containing 5% potassium hydroxide, fully stirred to dissolve, and filtered to obtain an alkali-alcohol solution. Add hydrochloric acid to acidify to pH 2-3, produce precipitate, stand overnight, filter, wash with 50% ethanol, dry, obtain the rhubarb extract containing total free anthraquinones. Carry out chemical composition analysis and determine the content of total free anthraquinone according to the above method, the main components are anthraquinone derivatives such as rhein, emodin, chrysophanol, rheum methyl ether and aloe-emodi...

Embodiment 3

[0044] 5 kg of rhubarb medicinal material, crushed, added 7 times the amount of 50% ethanol, heated and refluxed for 3 times, 1 hour each time, filtered, combined the extracts, recovered the solvent, and obtained an extract equivalent to about 2 g rhubarb / ml. Add 300ml of concentrated hydrochloric acid under stirring, hydrolyze at 70°C for 4 hours, cool, filter, and wash with water until pH 5-6 to obtain a precipitate. The precipitate was pulverized, added to a 60% ethanol solution containing 5% sodium hydroxide, fully stirred to dissolve, and filtered to obtain an alkali-alcohol solution. Add hydrochloric acid to acidify to pH 1-2, produce precipitate, leave overnight, filter, wash with 70% ethanol, dry, obtain rhubarb extract containing total free anthraquinones. Carry out chemical composition analysis and determine the content of total free anthraquinone according to the above method, the main components are rhein, emodin, chrysophanol, emodin methyl ether and aloe-emodin a...

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Abstract

A Chinese medicine for preventing and treating the chronic complications of diabetics, such as the diabetic nephrosis, eye diseases and microangium disease, is prepared from rhubarb, scutellaria root and medical additive through extracting the free anthraquinone from rhubard, extracting scutelloside from scutellaria root, and post-processing. Said extracting process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating chronic complications of diabetes and a preparation method of total free anthraquinones of rhubarb in effective pharmaceutical ingredients thereof. Background technique [0002] Diabetes is a common and multiple disease, and its harm to human health is mainly manifested in various chronic complications caused by it, such as diabetic nephropathy, diabetic eye disease and other microvascular diseases are some of the more common chronic diseases. complication. There have been studies and reports on the use of rhubarb rhubarb or some of its components as therapeutic drugs. [0003] Rhubarb is an important and commonly used traditional Chinese medicine, which has the functions of purging heat and dredging intestines, cooling blood and detoxifying, removing blood stasis and stimulating menstruation. It has been reported in the literature that its chemical components are mainly tannins and a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/122A61K36/539A61P3/10
Inventor 谭正怀易进海
Owner SICHUAN INST OF CHINESE MATERIA MEDICA
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