45results about How to "Improve neurological symptoms" patented technology

The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.

The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.

The invention relates to application of gamma-aminobutyric acid in preparation of foods, health-care products or medicines for relieving asthenopia, and belongs to the field of medical health. The invention adopts the technical scheme that the application of the gamma-aminobutyric acid in preparation of the foods, health-care products or medicines for relieving the asthenopia is provided. The invention also provides a composition for relieving the asthenopia; the active ingredients comprise gamma-aminobutyric acid, and one or two or more of anthocyanin, astaxanthin and procyanidine. Proofed bytrial results of users, the composition has the advantages that the local symptom of eyes with asthenopia is solved, the psychosomatic manifestations due to different degrees of asthenopia can be more obviously relieved, such as unconcentrated attention and decreased memory, the effect of relieving the asthenopia is obvious, and the market prospect is broad.

The invention discloses application of 5-(3', 5'-dimethoxybenzylidene)-2-sulfo-imidazole-4-one to preparation of drugs for treating cerebrovascular diseases. According to relevant researches disclosed by the invention, the compound has a remarkable cerebral nerve protection effect, can obviously reduce the volume of cerebral infarction of a focal cerebral ischemia rat and can obviously improve neurological signs; and moreover, the protection effect of an IV4 compound to cerebral ischemic injuries is related to the inhibition of the activation of lysosomal enzyme cathepsin B, so that the compound can be used for preparing drugs for preventing or treating diseases such as ischemic brain injuries, cerebral hemorrhage, cerebral thrombosis, cerebral embolism, cerebral infarction, cerebral stroke, lacunar infarction, transient ischemia attacks, cerebral arteriosclerosis and diabetic cardiovascular complications.

The invention provides a medicine for treating and / or preventing climacteric syndrome. The medicine is characterized by containing the following ingredients in parts by mass: 300-400 parts of radix paeoniae alba, 200-300 parts of prepared rehmannia root, 200-300 parts of medlar, 300-400 parts of astragalus membranaceus, 300-400 parts of herba epimedii, 300-400 parts of uncaria, 200-300 parts of cortex albiziae, 200-300 parts of poria cocos and 400-600 parts of oyster.

The invention discloses application of (E)-2-(3,5-dimethoxybenzylidene)-cyclopentanone in preparing a medicine for treating cerebrovascular diseases. The related research indicates that the compound has an obvious cranial nerve protection effect, obviously reduces the focal cerebral ischemia rat cerebral infarction volume and remarkably improves the neurologic symptom. The (E)-2-(3,5-dimethoxybenzylidene)-cyclopentanone is used for preventing or treating the diseases such as ischemic brain injury, cerebral hemorrhage, cerebral thrombosis, cerebral embolism, cerebral infarction, cerebral apoplexy, lacunar infarction, transient ischemic attack, cerebral arteriosclerosis, diabetic cerebrovascular complications and the like.

The invention discloses a traditional Chinese medicine combination, which is formed by raw medicines according to the proportion by weight as follows: ginseng or ginseng cauline leaf is 1 to 15 parts, and erigeron is 5 to 30 parts. Adopting the conventional traditional Chinese medicine combination formula, the invention has obvious neuroprotective effect and neural function improving, etc., by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the invention can effectively block most pathological mechanisms of a plurality of disease nerve injury such as ischemic cerebrovascular disease, etc.; more particularly, for the improved aspect to the neurological symptom,the traditional Chinese medicine injection is helpful to enhance the living quality of a patient, and achieves the purpose of improving prognosis, and has important clinical application significance.The invention further discloses a preparation method of the traditional Chinese medicine combination and the pharmaceutical application.

The invention discloses a micro-molecule polypeptide TAT-p53DM and an application thereof to preparing a medicine for treating or preventing ischemic stroke. A fusion protein polypeptide TAT-p53DM of a TAT protein transduction domain and p53DM is artificially synthesized; TAT carries p53DM protein polypeptide to pass through a blood brain barrier through blood so as to be taken by nerve cells; used in an in-vitro and in-vivo ischemic stroke model, the micro-molecule polypeptide TAT-p53DM is capable of effectively playing a biological role in blocking binding between death domain of death associated protein kinase 1 (DAPK1DD) and tumor suppression protein p53DNA binding motifs (p53DM), inhibiting signals capable of causing neuronal apoptosis and necrosis at DAPK1 downstream, and reducing ischemic stroke brain injury; moreover, molecular targets are provided for further developing medicines for clinically treating ischemic stroke.

The invention belongs to the field of health care products, and in particular relates to an anti-alcohol and liver-protecting agent containing chicory nutritional components and a preparation method thereof. The hangover-protecting agent is prepared from chicory oligopeptide, chicory coumarin, traditional Chinese medicine extract, honey and deionized water according to a certain ratio, wherein the chicory oligopeptide and chicory coumarin are extracted from chicory root, Chicory oligopeptides are rich in amino acids such as alanine and leucine, which can promote the production of coenzyme NAD+ of alcohol dehydrogenase, which is beneficial to the catabolism of ethanol in the body, inhibits the increase of ethanol in the blood, and achieves the purpose of hangover; chicory Coumarin can speed up cell repair and has obvious protective effect on liver cells. The traditional Chinese medicine extract is prepared by extracting kudzu root flower, kudzu root, panax notoginseng, milk thistle, chrysanthemum, citrus aurantii and nutmeg. The invention can inhibit the gastrointestinal absorption of alcohol through the mutual compatibility of the effective components, accelerate the metabolism of the alcohol, reduce the damage of the alcohol to the liver cells, and can play a significant effect of sobering up and protecting the liver.