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Medicine for treating angiocardiopathy and cerebrovascular disease and its preparing method

A technology for cardiovascular and cerebrovascular diseases and drugs, which is applied in the field of drug preparation, can solve the problems of slow onset of effect, long course of treatment, and low bioavailability, and achieve the effects of rapid onset of effect, clear active ingredients, and high bioavailability

Inactive Publication Date: 2004-12-29
陈玲玲
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  • Summary
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the traditional Chinese medicine preparations used clinically for the treatment of cardiovascular and cerebrovascular diseases are mainly oral preparations. Although oral preparations have certain curative effects, due to absorption through the digestive system, the onset of effect is slow, the bioavailability is low, and the course of treatment is long, which is still not enough for clinical use. needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 freeze-dried powder injection

[0024] (1) Take 1000g of Panax notoginseng, crush it, heat and reflux extraction with 10 times the amount of 65% ethanol each time, 3 times in total, 2 hours each time, combine the extracts, recover the ethanol under reduced pressure, add 1 times the amount of water to the concentrated solution , stir well, refrigerate for 24 hours, centrifuge at high speed, combine the supernatant, and set aside; the precipitate obtained by centrifugation is fully washed twice with water, combined with the lotion, filtered, and the filtrate is combined with the above-mentioned standby supernatant, and placed on an AB-8 large scale The pore adsorption resin chromatography column was eluted with deionized water and 60% ethanol successively, and the 60% ethanol eluate was collected, recovered under reduced pressure and concentrated to a relative density of 1.20 (60° C.), dried under reduced pressure to obtain three Seven extr...

Embodiment 2

[0028] The preparation of embodiment 2 injection

[0029] (1) Take 900g of Panax notoginseng, crush it, heat and reflux extraction with 8 times the amount of 70% ethanol each time, 4 times in total, 1.5 hours each time, combine the extracts, recover the ethanol under reduced pressure, add 1.2 times the amount of water to the concentrated solution , stir well, refrigerate for 28 hours, centrifuge at high speed, combine the supernatant, and set aside; the precipitate obtained by centrifugation is fully washed 3 times with water, combined with the lotion, filtered, and the filtrate is combined with the above-mentioned standby supernatant, and placed on an AB-8 large scale The pore adsorption resin chromatography column was eluted with deionized water and 70% ethanol successively, and the 70% ethanol eluate was collected, recovered under reduced pressure and concentrated to a relative density of 1.2 (60° C.), dried under reduced pressure to obtain three Seven extracts.

[0030] (...

Embodiment 3

[0033] The preparation of embodiment 3 big infusion

[0034] (1) Get 4000 g of Radix Astragali and 700 g of Radix Notoginseng, and prepare Radix Notoginseng extract, Radix Astragali extract and total polysaccharides respectively with (1) (2) (3) in Example 1.

[0035](2) Take the above ginseng extract, astragalus extract, and total polysaccharides, add 6000ml of water for injection and 500g of glucose, stir to dissolve, adjust the pH to 6.5-7.5 with 40% sodium hydroxide solution, refrigerate for 45 hours, and filter , filtrate adds water for injection and is diluted to 10000ml, then filters with the filter membrane of 0.45um and 0.22um respectively, and filtrate potting is in the transfusion bottle of 100ml / bottle, sterilizes, quality checks, promptly makes large infusion solution of the present invention.

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Abstract

The medicine for treating cardiac and cerebral vascular diseases is prepared with astragalus root and notoginseng as material, and is Chinese medicine injection, including injection liquid, transfusion liquid and freeze dried powder for injection, prepared through extraction, purification and addition of proper amount of medicinal supplementary material. The medicine has high stability and long effective period, and may be used in intramuscular injection, intravenous injection and intravenous instillation. Pharmacodynamic test shows that the medicine can protect brain against oxygen lack and cardiac muscle damage, raise anaerobic resistance, lower serum LDH and CK activity and reduce myocardial infarction range. The medicine is used in treating cardiac and cerebral vascular diseases and has fast acting, determined curative effect and no toxic side effect.

Description

Technical field [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases, in particular to a Chinese patent medicine prepared from traditional Chinese medicines Radix Astragali and Panax notoginseng as raw materials, and also relates to a preparation method of the medicine. Background technique [0002] Cardiovascular and cerebrovascular disease is one of the most serious diseases that endanger people's life and health, and its morbidity, disability rate and case fatality rate all account for the first of all kinds of diseases. Due to environmental pollution, changes in eating habits, and the accelerated pace of life, the incidence of cardiovascular and cerebrovascular diseases in my country is on the rise, and the population of patients is getting younger. At present, the traditional Chinese medicine preparations used clinically for the treatment of cardiovascular and cerebrovascular diseases are mainly oral preparations. Although ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61P9/00A61P9/10
Inventor 陈玲玲
Owner 陈玲玲
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