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Pharmaceutical composition containing lipoic acid and mecobalamin and preparation thereof

A kind of composition, the technology of methylcobalamin, applied in the field of medicine, can solve the problems such as no compound lipoic acid and methylcobalamin related documents and patent reports etc.

Inactive Publication Date: 2008-08-06
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Through the search, there are no relevant literature and patent reports on compound lipoic acid and methylcobalamin

Method used

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  • Pharmaceutical composition containing lipoic acid and mecobalamin and preparation thereof
  • Pharmaceutical composition containing lipoic acid and mecobalamin and preparation thereof
  • Pharmaceutical composition containing lipoic acid and mecobalamin and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 lipoic acid and methylcobalamin tablet

[0039] prescription:

[0040]

[0041] Preparation:

[0042] Pass lipoic acid and microcrystalline cellulose through a 80-mesh sieve, mix well, and set aside: take another appropriate amount of 50% ethanol solution, add methylcobalamin to dissolve, use this solution as a binder to make a soft material, and granulate with a 24-mesh sieve , dried at 50°C, granulated with a 20-mesh sieve, added with micropowdered silica gel and CMS-Na, mixed evenly, and pressed into tablets with a suitable die to obtain the product.

[0043] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

[0044] Care should be taken to avoid light during the above operations.

Embodiment 2

[0045] Embodiment 2: lipoic acid and methylcobalamin capsules

[0046] prescription:

[0047]

[0048]

[0049] Preparation:

[0050]Pass lipoic acid through an 80-mesh sieve, mix it with starch evenly, and set aside; take another appropriate amount of 50% ethanol solution, add methylcobalamin to dissolve, use this solution as a binder to make soft materials, and granulate with a 24-mesh sieve, 50 Dry at ℃, sieve through a 20-mesh sieve, add magnesium stearate, mix evenly, pack separately, and obtain.

[0051] The used capsule shell can be a common capsule or an enteric-coated capsule.

[0052] The above steps should be strictly protected from light.

Embodiment 3

[0053] Embodiment 3: lipoic acid and methylcobalamin soft capsules

[0054] prescription:

[0055]

[0056] Preparation:

[0057] Dissolve methylcobalamin and lipoic acid in PEG400, add propylene glycol, stir well, adjust the weight of the contents, and press.

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PUM

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Abstract

The invention relates to medical composition containing lipoic acid and mecobalamin and a preparation method and application thereof. The medical composition is formed by taking the lipoic acid and mecobalamin as medical active components and blending with pharmaceutically acceptable auxiliary materials; the medical composition can be used for the treatment of abnormal feeling caused by peripheral neuropathy of diabetes. The invention adopts the lipoic acid and mecobalamin as materials and adds auxiliary materials with some special kinds and proportions to prepare and develop diversified oral preparations such as tablets, capsules, granules, dispersible tablets, orally disintegrating tablets, buccal tablets, dry suspensions, pills drops, soft capsules, effervescent tablets and effervescent granules as well as preparations used for intravenous injection such as injections and freezing dried powder according to the technical method of the invention.

Description

technical field [0001] The invention relates to a pharmaceutical composition with lipoic acid and methylcobalamin as active components, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Lipoic acid is widely used in the treatment of diabetic neuropathy. In vitro tests show that this product can reduce lipid oxidation in nerve tissue, this product may prevent protein glycosylation; and it can inhibit aldose reductase, thus preventing glucose or galactose from converting into sorbitol, so lipoic acid It can prevent diabetes, control blood sugar and prevent neuropathy caused by high blood sugar. [0003] Lipoic acid is a powerful antioxidant whether in water-soluble or oil-soluble matrix. Both lipoic acid and its reduced form dihydrolipoic acid can exert antioxidant effects. They can directly or indirectly promote the regeneration of vitamin C and vitamin E. Studies have shown that lipoic acid can inc...

Claims

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Application Information

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IPC IPC(8): A61K31/385A61K31/714A61P3/10A61P25/02
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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