The invention discloses body-building anti-aging health-care wine, which is prepared by the following steps of: putting a certain amount of six-powder, tangerine peel, divaricate saposhnikovia root, Chinese wolfberry, white paeony root, clematis root, eucommia bark, cassia bark, Indian buead, liquorice root, achyranthes bidentata, Chinese thorowax root, angelica polyclada, star anise, szechuan lovage rhizome, rehmanniae vaporata, spiny jujube kernel, fragrant solomonseal rhizome, root of straight lady bell, Chinese date and largeleaf gentian root into a vessel containing a certain amount of white wine for soaking at room temperature for three days, and then adding a proper amount of rock candy and cold boiled water into the vessel; closing the vessel, standing the vessel for 120 to 130 days, and obtaining primary liquor through filtration; crushing a proper amount of safflower, medicinal Indianmulberry root, herba rhodiolae, Chinese leek seed, cornus fruit, angelica, tuber fleeceflower root, fructus hippophae and radix astragali, putting the crushed mixture into the vessel, mixing the mixture in the vessel uniformly, and standing the vessel for 8 to 32 days; crushing 10 to 14 grams of cordyceps, adding the crushed cordycepts into the vessel, mixing the mixture in the vessel uniformly, and standing the vessel for 70 to 74 hours; and obtaining the body-building anti-aging health-care wine through filtration. The body-building anti-aging health-care wine has the effects of improving the immunity of human bodies, getting rid of diseases, strengthening the body, building the body, and resisting aging.