The invention discloses a preparation method of a Chinese medicine lotion used for the treatment of the soft tissue wound of the chest wall, pertaining to the technical field of the preparation methods of Chinese medicine. Currently, anti-infective drugs are usually adopted for the treatment of the soft tissue wound of the chest wall, with allergic reactions of different types being possible to occur. Large dose of medicines possibly causes neurotoxic reactions and pneumonedema. The technical proposal of the invention is that radix salviae miltiorrhizae, motherwort herb, radix curcumae, rhizoma curcumae longae, excrementum pteropi, radix achyranthis bidentatae, lacca sinica exsiccate, herba verbenae, Chinese rose flower, muskmelon seed, hairy holly root, rhizoma cyperi, radix aucklandiae, combined spicebush root, pericarpium citri reticulatae viride, Amomum cardamomum, fructus meliae toosendan, citron skin, fructus citri sarcodactyli, lignum aquilariae, rose, trifoliate-orange immature fruit, cassia twig, wooly datchmanspipe herb, mulberry twig, radix clematidis, notopterygium incisium and licorice roots northwest origin are taken and dipped in water, and then gently decocted by slow fire and filtered to remove dregs of the decoction. The decocted liquid medicine is prepared to the Chinese medicine lotion used for the treatment of the soft tissue wound of the chest wall. The preparation method of the invention has the advantages that the Chinese medicine lotion has simple preparation, and the prepared Chinese medicine has little toxic and side effects and can directly access to the diseased region and be easily absorbed, with short therapeutic duration and high cure rate.