44results about How to "Increased systolic function" patented technology

The present invention relates to targeted RNAi for the treatment of heart failure by modulating defective cardiac Ca2+ homeostasis via decreasing expression or activity of phospholamban (PLB) using adeno-associated virus (AAV) transfection of cardiomyocytes. Methods for decreasing ventricular arrhythmias, as well as methods for overall improvement of survival from heart failure in subjects are also disclosed. Further, the present invention provides methods which can be used to diagnose susceptibility to treatment by RNAi, and includes pharmaceutical compositions, kits and vectors including an RNAi sequence.

Devices and methods whereby therapeutic agents may be injected into distinct organ locations in a minimally invasive manner. Most preferably the devices and methods employ a video-assisted thorascopic system (VATS) to enable a physician in real time to visually identify a distinct organ location into which therapeutic agent is to be injected. In particularly preferred forms, devices are provided for injecting a therapeutic agent into a tissue site which include a proximal handle, and a tubular barrel distally extending from the handle. The barrel has an injection needle at a distal end thereof which is most preferably angled relative to the barrel's elongate axis. The internal space of the barrel is sized and configured to receive a cartridge containing a therapeutic agent to be injected into the tissue site. A plunger assembly and injection trigger assembly are provided so as to cause the plunger to expel a predetermined volume of the therapeutic agent from the cartridge to the needle and thereby allow injection thereof to the tissue site in response to operation of the trigger assembly.

A method of treating and / or preventing oxidative damage, comprising administering an effective IsoK / NeuroK adduct formation suppressing amount of a phenolic amine compound and / or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.

A simulative magic ball is a simulative batting device for training actions and skills of a plurality of competitive balls with simulative batting method for the first time. The simulative magic ball belongs to the field of family physical exercise or game toys. A plurality of ball exercises can be enjoyed in an ordinary home. The simulative batting method is easily mastered and the skills of the competitive balls are quickly improved. The simulative magic ball can strengthen the body, train strong basic skills, and provide great joys. Taking simulative table tennis as example, specific skills such as push and block, cut, lift, drive, sidespin, loop drive, and the like, can be practiced. The simulative magic ball can be used for training badminton, foot shuttlecock skills, etc. The device can be extended to play skill games, the batting difficulty and entertainment fun can be increased by a compound pendulum and a conical pendulum. In the simulative batting and games, physical knowledge is combined. Teenagers can deeply understand and research into the corresponding physical phenomena, get relieved from muscle and bone, prevent from short sight, and release pressure. The simulative magic ball has the advantages of physical training, physics learning and eyes exercise, and is applied to family sports and student exercise.

The invention discloses a plant extract preparation for preventing astriction of senile. The ingredients and weigh shares are: 30-40 shares of senna extract, 30-40 shares of aloe extract, 20-30 shares of areca nut extract, 304 shares of oryzanol, 20-30 shares of calcium lactate, and proper amount of accessories. The invention uses the active ingredients in natural plants scientifically and naturally, pointing to the reason of senile astriction, carries on further treatment and prevention, and solves the problem of astriction in cell parallel. Because the active ingredients of the preparation are from the extract of natural plant, and it has target direction performance, it has no toxin and side effects.

The invention provides a folium ginkgo health product for preventing senile dementia, which comprises raw materials by weight portions: 10-30 portions of folium ginkgo, 10-20 portions of polygala tenuifolia, 10-20 portions of prepared rehmannia root, 10-20 portions of Chinese angelica, 10-20 portions of dogwood, 10-20 portions of root of red-rooted salvia, 10-20 portions of poria with hostwood, 10-20 portions of walnut kernel, 10-20 portions of codonopsis pilosula, 10-20 portions of platycladi seed, 10-20 portions of herba epimedii, 10-20 portions of astragalus mongholicus, 10-20 portions of polygonum multiflorum, 10-20 portions of white paeony root, 10-20 portions of fructus ligustri lucidi, 10-20 portions of bunge cherry seed, 10-20 portions of albizia flower and 10-20 portions of tuber fleeceflower stem. The folium ginkgo is extracted, the effective ingredients of the folium ginkgo are retained, the toxicity is reduced, and medicine directly reaches lesions to regulate qi and blood and balance yin and yang. On the one hand, the brain cell shrinkage function is improved, the conditions of Qi-stagnation and blood stasis and venation with the blood stasis are improved, qi and blood keep unblocked, and the blood oxygen supply of brain tissue is secured; and on the other hand, the damaged brain cell tissue is repaired and activated, and the normal brain function is restored.

The invention discloses a drug novel use of fucoidan polysaccharide sulfate. The use is the application of the fucoidan polysaccharide sulfate in preparing the following products: (1), a product for preventing and / or treating diabetic cardiomyopathy; (2), a product for inhibiting diabetic myocardial oxidative stress; and (3), a product for inhibiting expression and activation of PKC (Protein Kinase C) beta in diabetic cardiomyopathy; and (4), a product for relieving cardiac interstitial fibrosis of a diabetic. The fucoidan polysaccharide sulfate is preferably LMWF (Fucoidan Polysaccharide Sulfate) with weight-average molecular weight of 3-30KD. According to the pharmacodynamic experiment, the LMWF can be used for generating beneficial interference to the development of pathogenetic condition of the diabetic cardiomyopathy by strengthening the myocardial systolic function and relieving cardiac fibrosis. More importantly, the LMWF can be used for effectively inhibiting oxidative stress by regulating the activity of antioxidase, and can be used for inhibiting the expression of protein kinase C beta (PKCbeta) subtype. The LMWF is from the natural existing kelp, so that the availability and safety of the kelp are beneficial to using the fucoidan polysaccharide sulfate as a potential clinical treatment drug and preventing the diabetic cardiomyopathy.

The invention discloses feed special for gestational sows. The feed is prepared from corn flour, soybean meal, wheat bran, fish meal, cottonseed meal, oat meal, olive oil, armillaria luteo-virens yeast, kaolin, a traditional Chinese medicine additive and a nutrition additive. The feed is appropriate in integral nutrition and energy level, accords with the nutrition requirement rule of the gestational sows, can meet the nutrition requirements of quick growth and development of fetuses in late gestation, ensure reasonable birth weight and health vitality of piglets and provide appropriate energy reserve for the sows, cannot cause the phenomenon that the sows are too heavy and too fat and well decreases the occurrence rate of the problems that constipation, prolonged labor, dystocia and postpartum acute endometritis, mastitis, agalorrhea or lactation deficiency and reduction are generated on the sows.

The invention discloses a flexible driver for imitating skeletal muscle variable-rigidity distribution. The flexible driver for imitating skeletal muscle variable-rigidity distribution comprises a matrix, drive parts and an elastic fiber mesh, wherein multiple holding cavities are limited in the matrix from top to bottom and are arranged in parallel; the multiple drive parts are arranged in the holding cavities, communicate with an external air source and can drive the matrix to linearly contract through inflation and deflation; the elastic fiber mesh is arranged on the outer surface of the matrix in a sleeving way; and the distribution density of the elastic fiber mesh located on a middle-section matrix is smaller than the distribution density of the elastic fiber mesh located on an upper-section matrix and a lower-section matrix. Compared with an existing skeletal muscle imitating driver, the flexible driver for imitating skeletal muscle variable-rigidity distribution provided by theinvention has the following beneficial effects that the elastic fiber mesh is additionally arranged for imitating a connective tissue in the skeletal muscle, so that a contraction function of the imitated skeletal muscle is promoted, and the whole drive force is improved. Through the elastic fiber mesh, the drive forces produced by the drive parts are uniformly transmitted to the whole muscle, sothat the endurance of the imitated skeletal muscle is improved. Through controlling the distribution density of the elastic fiber mesh on the outer surface of the matrix, the characteristic of rigidity heterogeneity is imitated.

The present invention pertains to the field of biotechnology and medicine and discloses a usage of Heat Shock Protein 27(HSP27) in the heart protection aspect. The present invention firstly reveals that the HSP27 gene can be applied in the specific myofilament protein for stabilizing ischemia, heart failure and other damages of the heart muscle, so as to improve the contractile function of the heart muscle; the present invention also proves that the HSP27 transfected by the adenovirus vector can improve the contractile function of the heart with ischemia and can provide an effective new target for the treatment of heart diseases.

The invention provides a traditional Chinese medicine preparation for curing benign prostatic hyperplasia. Active ingredients of the preparation are prepared from the following raw materials according to weight ratio: 10-15 of radix glehniae, 9-12 of caesalpinia, 10-15 of light red Tuckahoe, 10-15 of root of common peony, 3-6 of radix glycyrrhizae preparata, 10-20 of raw rehmannia, 5-10 of plantain seed, 10-15 of liriope, 3-10 of inula lineariifolia turcz, 6-15 of cortex lycii radicis, and 10-15 of grilled astragalus. The dosage form of the prepared medicine is one of oral liquid, capsule, troche, pill and powder. The preparation disclosed by the invention not only can be used for tonifying Qi, clearing away the heart-fire, circulating heart and kidney, smoothing kidney water, enhancing bladder systolic function, promoting reduced volume of prostate and effectively relieving bladder outlet obstruction symptoms, but also can be used for coordinating balanced action on human blood and physiological function of the five internal organs (a heart, a liver, a spleen, lungs and kidneys), conditioning qi activity and achieving the purposes of treating disease from the root; furthermore, the preparation has the advantages of being light in dosage, accurate in curative effect, short in treatment course, high in cure rate, low in operation curing probability, low in side effect, and the like.

The invention relates to the technical field of medicines, in particular to application of quercetin and kaempferol in preparation of products for preventing or treating hereditary cardiomyopathy. The hereditary cardiomyopathy comprises dilated cardiomyopathy, hypertrophic cardiomyopathy and restricted cardiomyopathy. According to the product for preventing or treating cardiomyopathy, accumulation of active oxygen in myocardial cells and superoxide in mitochondria is reduced, intracellular DNA damage caused by ROS accumulation is relieved, the contractility of the myocardial cells is increased, and cardiomyopathy is prevented or treated. The new application of the quercetin and the kaempferol provides a new choice for development of drugs for preventing or treating the hereditary cardiomyopathy, expands the application range of the quercetin and the kaempferol, provides a new direction for clinical treatment of the hereditary dilated cardiomyopathy, and also brings a new vitality for clinical application of Chinese herbal medicine substances.

The invention is a method for controlled regional reperfusion using ATP-MgCl2 after percutaneous coronary revascularization for acute myocardial infarction, the method comprising the step of administering an effective amount of ATP-MgCl2 to the step of administering an effective amount of ATP-MgCl2 to the infarct-related vessel(s), such as at a dosage level of at least 0.03 mg / kg / min. The method also includes a method for controlled regional reperfusion using ATP-MgCl2 after percutaneous coronary revascularization for acute myocardial infarction, the method comprising the steps of (a) performing cardiac catheterization and coronary angiogram; (b) identifying the infarct-related vessel; (c) performing a left ventriculogram and calculating the left ventricular ejection fraction; and (d) performing a percutaneous coronary intervention; and after percutaneous revascularization of the infarct related vessel, infusing ATP-MgCl2 intracoronary, preferably at a rate of at least 0.03 mg / kg / min through the balloon catheter.

The invention discloses a novel grape shoot-cutting machine. The machine is composed of a frame, a cutting system, a cutter driving mechanism, a hydraulic system, a direction adjusting system, etc.

The invention belongs to the field of traditional Chinese medicine preparations, and relates to a medicine preparation used for treating chronic cardiac failure and a preparing method thereof. According to the method, antler gelatin, epimeddium, glossy privet fruit, psoralea fruit, dogwood fruit and dried orange peel are used as the main raw materials, subjected to microwave drying or vacuum drying to obtain dry extract, and the granulated by utilization of a dry method or a wet method to obtain compound antler granules. The extract powder obtained by the microwave drying method or the vacuum drying method is beneficial to granulation. The amount of auxiliary materials is small and the amount taken a day is small, thus improving patient compliance. In particular, the amount of the auxiliary materials is reduced and the moisture-proof performance of the granules is significantly enhanced at the same time. The rate of finished products of the granules is not less than 90%. The granules have functions of regulating and tonifying yin and yang, warming the spleen and strengthening the heart, and are especially suitable for chronic cardiac failure which is discriminated to belong to deficiency of the kidney by the traditional Chinese medicine. The preparation method is simple in technology, high in production efficiency and low in cost, and is suitable for continuous and automatic production.

A mechanical synchronous shrinkage door belongs to the field of machine electricity, and is applied in emergent escape when doors are deadly stuck under the conditions, such as daily house theft prevention, earthquake, fire and the like. The door adopts a pure mechanical structure to guarantee normal, stable and reliable operation in disaster emergency. A one-key trigger is additionally provided to leave out a larger space in a door body when enabling the door body to has a shrinkage function, so that reinforcement of the door body and other operations are conveniently implemented. The door guarantees the shape and the theft prevention function of the normal door body, and has one added function of dead locking prevention compared with existing security doors in the market. The door is suitable for the emergent escape under the conditions, such as daily house theft prevention, earthquake, fire and the like, and has a larger actual application space.

The invention discloses a Chinese medicinal formula for treating lithangiuria. The Chinese medicinal formula consists of the following raw materials in parts by weight: 5-15 parts of white atractylodes rhizome, 10-20 parts of gynostemma pentaphyllum, 5-15 parts of wild chrysanthemum, 15-25 parts of fructus forsythia, 10-20 parts of lotus leaf and 10-20 parts of scutellaria barbata. The traditional Chinese medicine for treating the lithangiuria has the functions of stimulating menstrual flow, dredging the channel, promoting blood circulation to remove blood stasis, clearing heat, promoting diuresis, diminishing inflammation, relieving pain, softening hardness to dissipate stagnation, lowering lipid, dissolving stone, increasing fluid secretion and contracting capsule walls, and continuously pushes the stone to move downwards to achieve the effect of quickly expelling the stone from the body.

The invention discloses traditional Chinese medicine for treating carotid plaque and belongs to the technical field of Chinese herbal medicine preparations. The traditional Chinese medicine is prepared from, by mass, 3 g of panax notoginseng powder, 15 g of prepared radix polygoni multiflori, 20 g of radix puerariae, 15 g of fructus crataegi and 5 g of hirudo. The preparation method includes the steps that the panax notoginseng powder, prepared radix polygoni multiflori, radix puerariae, fructus crataegi and hirudo are prepared into particles and mixed, and the traditional Chinese medicine is prepared. Pure natural Chinese herbal medicine is particularly selected for the rigorous formula, the traditional Chinese medicine has the effects of nourishing the liver and the kidney, eliminating stasis and softening hard masses, accelerating elimination of carotid plaque and reducing the risk of stroke episode of a patient. The traditional Chinese medicine lowers morbidity, the death rate and the disability rate, relieves pain of the patient, improves living quality of the patient and is safe, free of toxin or side effects after being taken for a long time and more convenient to take after being decocted. The traditional Chinese medicine is low in cost and can relieve the economic burden of the patient and household.

The invention relates to a five-element precious stone waist and abdomen health care belt, which comprises a waist and abdomen belt body, wherein connecting elements which are mutually matched are arranged at the two ends of the waist and abdomen belt body; a plurality of precious stone integrating blocks are arranged on at least one position, corresponding to the abdomen and the waist, of the waist and abdomen belt body; and each precious stone integrating block comprises a soft and air-permeable outer covering layer and a plurality of precious stone fragments wrapped in the outer covering layer. The precious stone integrating blocks with the five-element attributes of gold, wood, water, fire and earth are arranged on the inner side surface of the corresponding positions of the waist and abdomen belt body; each precious stone integrating block consists of a plurality of precious stone fragments; the precious stone fragments can be combined by precious stones with different five-element attributes; the precious stone integrating blocks have anti-radiation performance; more importantly, the five-element attribute elements and mineral substances can be continuously released; the energy required by human bodies can be regulated and supplemented; the released five-element attribute elements stimulate the meridians and collaterals, the acupuncture points and the lesion positions of the human bodies; and the five-element precious stone waist and abdomen health care belt can be cleaned at any time and can be used for many times.

The present invention provides an acrylic shrinkable fiber that can be dyed even if the fiber has a fineness of 1 dtex or more, and has a high shrinkage function even after dyeing, and a fleece fabric product using the same. The acrylic shrinkable fiber of the present invention is characterized in that it contains 40 to 93% by weight of acrylonitrile, 2 to 10% by weight of monomers containing sulfonic acid groups, and 5 to 58% by weight of monomers that can be copolymerized with the above components. It is formed by the copolymer of the body, and the average fineness is above 1dtex.

The invention relates to an anticoagulation-free heart auxiliary contraction device. The anticoagulation-free heart auxiliary contraction device comprises a central processing unit (1), and a power supply (4), an electrocardiogram monitoring module (7) and a flexible driving shell (5) which are connected with the central processing unit (1); the flexible driving shell (5) is used for wrapping the outer side of a heart (8) and comprises a plurality of contraction bags (51) which are arranged in a tiled manner; a liquid medium (52) is hermetically stored in each contraction bag (51), and an electrode (6) connected with the central processing unit (1) is arranged on the outer surface of each contraction bag (51); and each electrode (6) comprises a negative electrode (61) and a positive electrode (62), and the negative electrode (61) and the positive electrode (62) are arranged on two opposite sides of the corresponding contraction bag (51) respectively. Compared with the prior art, the device is high in flexibility, simple in structure, small in size, convenient to install, good in safety and capable of effectively driving blood to flow and improving the overall pulsation volume of the heart.

The invention discloses compound feed for pregnant sows in expected date of delivery. The feed is prepared by smashing and mixing following raw materials by weight: 55-65 parts of corn, 8-15 parts of soybean pulp, 2-10 parts of corn gluten powder, 3-8 parts of malt sprout, 0-3 parts of soybean oil, 2-8 parts of middlings, 3-5 parts of full-fat soybean, 0-8 parts of wheat bran, 0.4-0.6 part of a microelement premix, 0.4-0.6 part of a vitamin premix, 1.0-1.5 parts of calcium hydrophosphate, 0.2-0.4 part of edible salt, 0.5-1.0 part of stone powder, 0.2-0.5 part of lysine, 0-0.2 part of threonine, 0.08-0.1 part of tryptophan, 0.3-0.8 part of yeast culture, 0.1-0.12 part of choline and 0.1-0.4 part of magnesium sulfate. According to the feed, requirements of rapid growth of fetus in the latter half period of gestation of the sows are met, and reasonable birth weights and vitality are guaranteed; contraction functions of uterine and intestinal smooth muscles of the sows under the condition of high abdominal pressure are guaranteed; problems, namely difficult delivery, prolonged delivery, postpartum triad syndrome, and the like, occurred to the sows during delivery and lactation are reduced; and sow production performances are improved.

The invention discloses a fitness rehabilitation device for actively correcting spinal deformation. The fitness rehabilitation device for actively correcting spinal deformation comprises an arc bed, bed front legs and bed rear legs, wherein the bed front legs and the bed rear legs are arranged under the front end and the rear end of the arc bed; a hand gripper A is arranged at one extending end, close to the front bed legs, of the arc bed; a hand gripper B is arranged under the middle position of the arc bed; a pedal plate A, a pedal plate B and a pedal plate C are sequentially arranged at theother end of the arc bed; the pedal plate A and the pedal plate B are arranged on the connecting plate; one end of the connecting plate is arranged at one end of the arc bed; and retaining grooves are uniformly formed in the upper surface of the connecting plate at intervals so as to be used for placing the pedal plate B. The fitness rehabilitation device for actively correcting spinal deformation provided by the invention is simple in structure; and through applying the gravity of a human body to combine with the arc bed, a spine is pulled back to the original position, so that the normal bending of cervical curve, thoracic curve, lumbar curve and sacrum is maintained.

The invention provides a biological electromagnetic wave energy storehouse which mainly comprises a casing. Each side of the casing is sequentially provided with a heating layer, a metal sheet layer,a magnetic layer and an energy layer from outside to inside, and the layers wrap the casing. Articles including clothes, cups and accessories are arranged in the casing, the heating layer heats the magnetic layer and the energy layer, the casing can reach normal temperature to the high temperature of 120 DEG C, different wavelengths magnetic forces of the magnetic layers and radiation energy wavesof the energy layer are formed, the travel speed and penetrating force of the energy waves are improved at the high temperature, the energy waves are adhered to the different articles in the casing,and thus, when being used, the articles with the energy waves can strengthen and balance bioelectric signals and activities and biologic electromechanical reaction, prompt blood circulation, recover the angiotasis, improve blood supply, improve devices with functional blood circulation obstacles, adjust autonomic nerves, and improve the bioelectric activity and contraction functions of the cardiacmuscles.

The invention discloses a traditional Chinese medicine medicament for treating obesity cardiomyopathy and a preparation method. The traditional Chinese medicine medicament for treating obesity cardiomyopathy is prepared from the following raw materials in parts by weight: 15 g of wintercreeper, 10 g of rheum officinale, 12 g of ligusticum wallichii, 12 g of platycodon grandiflorum, 15 g of bighead atractylodes rhizome, 10 g of fenugreek, 20 g of dried pueraria lobota, 15 g of radix angelicae, 20 g of hawthorn, 20 g of pinellia ternate, 15 g of poria cocos, 20 g of Chu pine nuts, 20 g of sophora fruit, 20 g of raw sophora flower, 15 g of codonopsis pilosula, 20 g of medlar and 12 g of lotus seed. The traditional Chinese medicine medicament for treating obesity cardiomyopathy disclosed by the invention is safe and free from side effects, low in calories, high in protein, low in fat, capable of reducing cholesterol and blood pressure and eliminating obesity, capable of enhancing the contraction function of the heart and remarkable boosting body immunity, and great in treatment effect on obesity cardiomyopathy in case of being taken for a long time.

The invention discloses a traditional Chinese medicine preparation for beauty maintenance and skin tendering. The traditional Chinese medicine preparation is prepared from raw materials in parts by weight as follows: 5-15 parts of folium sennae, 5-15 parts of raw rhubarb, 25-35 parts of mirabilite, 0.5-5 parts of radix euphorbiae kansui, 5-15 parts of semen arecae, 0.5-5 parts of lignum aquilariae resinatum, 1-5 parts of fructus aurantii immaturus, 0.5-5 parts of radix aucklandiae, 1-5 parts of herba cistanches, 1-2 parts of rhizoma atractylodis macrocephalae, 1-3 parts of wheat bran, 1-2 parts of rivier giantarum rhizomes, 1-2 parts of inulin, 1-3 parts of flos lonicerae, 1-2.8 parts of herba taraxaci, 1-3 parts of flos carthami, 1-2 parts of rhizoma imperatae and 1-2 parts of rhizoma polygonati odorati. The traditional Chinese medicine preparation has effects of clearing heat-fire, maintaining beauty and tendering skin and has a remarkable treatment effect and no side effects.

The invention relates to preparation and application of an ischemic myocardial targeted mitochondria-directed peptide compound, and belongs to the technical field of biological medicines. According to the invention, mitochondria recognition molecules and ischemic myocardial cell targeting peptides are combined and react with active mitochondria to form a mitochondria-TPP + CSTSMLKAC compound, and ischemic myocardial injury is treated through vein transplantation; the guiding peptide CSTSMLKAC can guide mitochondria to a myocardial ischemia area, damaged myocardial cells enhance self energy metabolism by taking in exogenous mitochondria, mechanical contraction and relaxation functions of myocardial energy dependent myocardial cells are improved, damage caused by myocardial cell apoptosis is inhibited, and heart failure is delayed; and after vein transplantation of the mitochondria-TPP + CSTSMLKAC compound, the cardiac dysfunction can be relieved. A mitochondrial transplantation approach can be remarkably simplified through vein transplantation of mitochondria, the application cost of mitochondrial transplantation is reduced, and the ischemic myocardial targeted mitochondria-directed peptide compound has important clinical popularization and application value.

The Chinese medicine preparation for treating chronic heart failure is prepared with the Chinese medicinal materials antler glue or antler tablet, epimedium, privet fruit, malaytea scurfpea fruit, dogwood and dried orange peel in certain proportion. The preparation process includes decocting the medicine materials except antler glue or antler tablet, high speed centrifuging to eliminate impurity, concentrating the supernatant, spray drying to obtain extractum powder, adding antler powder and supplementary material, and preparing oral preparation via conventional process. The Chinese medicine preparation has high active component content, determined curative effect and easy preparation, and is suitable for industrial production.