The invention discloses application of a traditional Chinese medicine composition for preparing drugs for preventing and treating acute myocardial infarction post percutaneous coronary intervention (PCI) no-reflow, wherein the traditional Chinese medicine composition of the invention comprises ginseng, leech, centipede, scorpio, ground beeltle, cicada slough, root of common peony, borneol and the like, and has effects of tonifying qi, invigorating the circulation of blood, eliminating blood stasis and dredging collateral. The clinical study shows that the traditional Chinese medicine composition in the invention can treat and prevent the acute myocardial infarction post PCI no-reflow.