83results about How to "Inhibit oxidative stress" patented technology

The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

The invention discloses a multifunctional lactobacillus fermentum CCFM1051 for relieving PFOA toxicity and fermented foods and application thereof. The invention screens out probiotics which have highadsorption capacity on PFOA, do not colonize in human bodies and have high oxidation resistance; and the probiotics not only can inhibit oxidative stress caused by the PFOA, but also can fundamentally eliminate the PFOA in human bodies. The lactobacillus fermentum CCFM1051 can be used for preparing foods, health products and medicines with PFOA toxicity relieving effect, and has wide applicationprospect.

The invention discloses a drug novel use of fucoidan polysaccharide sulfate. The use is the application of the fucoidan polysaccharide sulfate in preparing the following products: (1), a product for preventing and / or treating diabetic cardiomyopathy; (2), a product for inhibiting diabetic myocardial oxidative stress; and (3), a product for inhibiting expression and activation of PKC (Protein Kinase C) beta in diabetic cardiomyopathy; and (4), a product for relieving cardiac interstitial fibrosis of a diabetic. The fucoidan polysaccharide sulfate is preferably LMWF (Fucoidan Polysaccharide Sulfate) with weight-average molecular weight of 3-30KD. According to the pharmacodynamic experiment, the LMWF can be used for generating beneficial interference to the development of pathogenetic condition of the diabetic cardiomyopathy by strengthening the myocardial systolic function and relieving cardiac fibrosis. More importantly, the LMWF can be used for effectively inhibiting oxidative stress by regulating the activity of antioxidase, and can be used for inhibiting the expression of protein kinase C beta (PKCbeta) subtype. The LMWF is from the natural existing kelp, so that the availability and safety of the kelp are beneficial to using the fucoidan polysaccharide sulfate as a potential clinical treatment drug and preventing the diabetic cardiomyopathy.

The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

The disclosure provides compositions treating traumatic brain injuries such as concussions. In one embodiment, the composition comprises phosphatidylserine, phosphatidylcholine, quercetin, astaxanthin, R-alpha lipoic acid, N-acetyl cysteine, taurine, L-glutamine, carnitine, D-ribose, creatine, epigallocatechin gallate, melatonin, ginkgo leaf extract, curcumin and L-glycine. The disclosure also provides methods for treating traumatic brain injuries such as concussions by administering an effective amount of the compositions described within.

The invention provides application of Vietnamese ginsenoside R4 in preparation of a medicament for treating neurodegenerative diseases, in particular to the application in preparation of a medicamentfor treating Parkinson's disease. According to the application, by designing an in-vitro Parkinson model, Vietnamese ginsenoside R4 is proposed for the first time and proves to be capable of reducingcell damage, and the resistance effect on Parkinson disease is achieved by inhibiting oxidative stress of cells and regulating cell apoptosis. Therefore, the application of Vietnamese ginsenoside R4 as an effective medicament for treating Parkinson disease provides a basis for developing and expanding the medicament application of Vietnamese ginsenoside R4.

The invention discloses application of fructus chaenomelis betulinic acid in preparing a medicine for resisting hypertensive myocardial fibrosis, and belongs to the technical field of biological medicines. The fructus chaenomelis betulinic acid is applied to treat treating spontaneously hypertensive rats (SHR), and the result shows that after drug administration treatment for 12 weeks, blood pressure of each group of SHR is reduced, and serum endothelin (ET) contents of each dosage group of fructus chaenomelis betulinic acid and a captopril CAP group are remarkably reduced; the nitric oxide (NO) content is remarkably improved; according to each dosage group of fructus chaenomelis betulinic acid, the contents of MCP-1, TNF-alpha, IL-1, IL-6, CRP and MDA can be reduced, so that the result shows that the fructus chaenomelis betulinic acid can be beneficial to reducing of the content of cardiac muscle tissue inflammatory factors, reducing of damage of oxidative stress on tissues, improvingof tissue oxidation resistance, and improving of myocardial fibrosis through multiple target points.

Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc.

The invention provides an oxidative stress intervening and anticoagulation hemodialysis membrane and a preparation method and application thereof, and belongs to the technical field of membranes. Themethod comprises the following steps: 1) preparing a plant polyphenol mixed solution; 2) preparing a polyoxazoline mixed solution; 3) preparing an anticoagulant mixed solution; 4) enabling the plant polyphenol mixed solution to flow through a hemodialysis membrane at a constant temperature; 5) enabling the polyoxazoline mixed solution to flow through the plant polyphenol modified hemodialysis membrane at the constant temperature; and 6) enabling the anticoagulant mixed solution to flow through a hemodialysis membrane of the plant polyphenol-polyoxazoline modified hemodialysis membrane to obtain a product at the constant temperature. The membrane is mainly used for hemodialysis and can effectively achieve the purposes of inhibiting oxidative stress and preventing thrombus on the premise ofgood biocompatibility.

The invention relates to a compound fructus crataegi-turmeric root tuber particle, which is prepared from the following bulk pharmaceuticals in parts by weight: 130-170 parts of fructus crataegi, 60-90 parts of turmeric root tuber, 60-90 parts of oriental waterplantain rhizome, 80-120 parts of seaweed, 60-90 parts of bulb of thunberg fritillary, 80-120 parts of milk thistle and 40-60 parts of peach kernel. The invention further provides a preparation method for the compound fructus crataegi-turmeric root tuber particle. The method comprises the following steps of: weighing fructus crataegi, turmeric root tuber, oriental waterplantain rhizome, seaweed, bulb of thunberg fritillary, milk thistle and peach kernel according to parts by weight, and adding water for soaking; preparing micro-powder silica gel serving as a single auxiliary material of spray drying and lactose serving as an auxiliary material of particle forming, and standing for later use; adding water in an amount which is 4-10 times that of soaked Chinese medicinal materials including fructus crataegi, turmeric root tuber, oriental waterplantain rhizome, seaweed, bulb of thunberg fritillary, milk thistle and peach kernel for a first time, adding water in an amount which is 4-10 times that of the Chinese medicinal materials for a second time, and decocting; concentrating an obtained compound extract till the relative density is 1.065, adding an auxiliary material, i.e., micro-powder silica gel, performing spraying drying to obtain extract powder; and adding lactose and ethanol into the extract powder, uniformly mixing, granulating, drying and regulating particles.

The invention discloses an extract of Glycine tabacina (Labill.) Benth. The extract contains isoflavones, triterpenoids, scoparone and vanillic acid. The results of pharmacodynamic experiments show that the extract of Glycine tabacina (Labill.) Benth has obvious therapeutic effect on arthritis, can significantly reduce the degenerative changes of bones and destroy to cartilago articularis, decreases the expression of pro-inflammatory cytokines, inhibits oxidative stress, and provides a novel medication option for clinical treatment of arthritis.

The invention provides an oxidative stress intervening and anticoagulation hemodialysis membrane and a preparation method and application thereof, and belongs to the technical field of membranes. Themethod comprises the following steps: 1) preparing a plant polyphenol mixed solution; 2) preparing a polyoxazoline mixed solution; 3) preparing an anticoagulant mixed solution; 4) enabling the plant polyphenol mixed solution to flow through a hemodialysis membrane at a constant temperature; 5) enabling the polyoxazoline mixed solution to flow through the plant polyphenol modified hemodialysis membrane at the constant temperature; and 6) enabling the anticoagulant mixed solution to flow through a hemodialysis membrane of the plant polyphenol-polyoxazoline modified hemodialysis membrane to obtain a product at the constant temperature. The membrane is mainly used for hemodialysis and can effectively achieve the purposes of inhibiting oxidative stress and preventing thrombus on the premise ofgood biocompatibility.