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Oxidative stress intervening and anticoagulation hemodialysis membrane and preparation method and application thereof

A technology of hemodialysis and oxidative stress, applied in chemical instruments and methods, semi-permeable membrane separation, membrane technology, etc., can solve the problems of not being able to simultaneously play an anticoagulant effect, and not be able to improve the state of oxidative stress, and achieve practical value High, good biocompatibility, the effect of inhibiting oxidative stress

Active Publication Date: 2020-03-27
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing hemodialysis membranes on the market cannot improve the state of oxidative stress, let alone play an anticoagulant role at the same time

Method used

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  • Oxidative stress intervening and anticoagulation hemodialysis membrane and preparation method and application thereof
  • Oxidative stress intervening and anticoagulation hemodialysis membrane and preparation method and application thereof
  • Oxidative stress intervening and anticoagulation hemodialysis membrane and preparation method and application thereof

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preparation example Construction

[0043] The embodiment of the present invention proposes a method for preparing a hemodialysis membrane that interferes with oxidative stress and resists coagulation, including the following steps:

[0044] 1) preparing plant polyphenol mixed solution;

[0045] 2) preparing polyoxazoline (POZ) mixed solution;

[0046] 3) preparing an anticoagulant mixed solution;

[0047] 4) At a constant temperature, flow the above-mentioned plant polyphenol mixed solution through the hemodialysis membrane to obtain a plant polyphenol-modified hemodialysis membrane;

[0048] 5) At a constant temperature, the above-mentioned polyoxazoline mixed solution is passed through the above-mentioned plant polyphenol-modified hemodialysis membrane to obtain a plant polyphenol-POZ-modified hemodialysis membrane.

[0049] In the embodiment of the present invention, specific antioxidant substances, substances for improving blood compatibility and anticoagulant drugs are used to functionalize the membrane ...

Embodiment 1

[0087] Example 1 Preparation of plant polyphenol-POZ-anticoagulant modified hemodialysis membrane

[0088] 1) Hemodialysis membrane pretreatment: immerse the hemodialysis membrane in a beaker containing absolute ethanol for 0.5 h, then soak in deionized water for 0.5 h, and repeat this process 3 times. After treatment, the membrane was placed in deionized water for later use. Wherein, the hemodialysis membrane is a polyethersulfone membrane.

[0089] 2) Preparation of mixed solution of plant polyphenols: preparation of Tris buffer solution with a concentration of 1 g / L and a pH of 8.5. Add 2 g of plant polyphenols and 35.06 g of sodium chloride into 1 L of Tris buffer solution, stir for 5 minutes to fully dissolve, and obtain a uniform mixed solution of plant polyphenols; wherein, the plant polyphenols are tannic acid.

[0090] 3) Preparation of POZ mixed solution: preparation of a Tris buffer solution with a concentration of 1 g / L and a pH of 8.5. 3 g of 20% hydrolyzed P...

Embodiment 2

[0096] Example 2 Preparation of plant polyphenol-POZ-anticoagulant modified hemodialysis membrane

[0097]1) Hemodialysis membrane pretreatment: immerse the hemodialysis membrane in a beaker containing absolute ethanol for 0.6h, then soak in deionized water for 0.6h, and repeat this process 3 times; after treatment, the hemodialysis membrane The membrane was placed in deionized water until use. Wherein, the polymer membrane is a polysulfone membrane.

[0098] 2) Prepare plant polyphenol mixed solution: add plant polyphenol and metal salt to tris (Tris) buffer solution, stir for 3 minutes to obtain plant polyphenol mixed solution, make the plant polyphenol mixed solution of plant polyphenol The concentration is 2.5g / L, the final concentration of metal salt is 20g / L; the concentration of Tris buffer solution is 2g / L, and the pH is adjusted to 8.0 with HCl or NaOH aqueous solution with a concentration of 0.1mol / L; the plant polyphenol is caffeic acid , A mixture of cinnamic a...

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Abstract

The invention provides an oxidative stress intervening and anticoagulation hemodialysis membrane and a preparation method and application thereof, and belongs to the technical field of membranes. Themethod comprises the following steps: 1) preparing a plant polyphenol mixed solution; 2) preparing a polyoxazoline mixed solution; 3) preparing an anticoagulant mixed solution; 4) enabling the plant polyphenol mixed solution to flow through a hemodialysis membrane at a constant temperature; 5) enabling the polyoxazoline mixed solution to flow through the plant polyphenol modified hemodialysis membrane at the constant temperature; and 6) enabling the anticoagulant mixed solution to flow through a hemodialysis membrane of the plant polyphenol-polyoxazoline modified hemodialysis membrane to obtain a product at the constant temperature. The membrane is mainly used for hemodialysis and can effectively achieve the purposes of inhibiting oxidative stress and preventing thrombus on the premise ofgood biocompatibility.

Description

technical field [0001] The invention belongs to the field of membrane technology, and in particular relates to a hemodialysis membrane for intervening oxidative stress and anticoagulation, a preparation method and application thereof. Background technique [0002] In recent years, the number of patients with end-stage renal disease has been increasing. Due to renal insufficiency or even complete loss in such patients, hemodialysis has become the main measure to replace the kidney. However, the hemodialysis membrane is the core material of hemodialysis. Due to the biocompatibility of the dialysis membrane, it is easy to cause the adhesion and activation of leukocytes in the patient's blood, and a large number of reactive oxygen species (ROS) are generated during the dialysis process. ), excessive active oxygen free radicals lead to the disorder of its balance with antioxidant substances, resulting in oxidative stress; and, excessive active oxygen free radicals will react with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00B01D69/12B01D71/10B01D71/38B01D71/42B01D71/44B01D71/50B01D71/56B01D71/68B01D71/74
CPCB01D67/0002B01D69/12B01D71/10B01D71/38B01D71/42B01D71/44B01D71/50B01D71/56B01D71/68B01D71/74
Inventor 何洋陈琦陈莉赵义平
Owner TIANJIN POLYTECHNIC UNIV
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