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41 results about "Cartilago articularis" patented technology

Preparing method for infrared response high-strength hydrogel for cartilago articularis repair

InactiveCN105107019AImprove mechanical propertiesEfficient photothermal conversion effectProsthesisCross-linkSide chain
The invention discloses a preparing method for infrared response high-strength hydrogel for cartilago articularis repair. The preparing method mainly includes the operation steps that polysaccharide or protein is modified in a double bond forming mode through methacrylic acid, methacrylic anhydride and methacrylate substances, so that the polysaccharide or the protein has a double-bond group in a side chain and is capable of being polymerized to form the hydrogel. Under the action of an initiator and a cross-linking agent, N-isopropyl acrylamide and the polysaccharide or the protein modified in the double bond forming mode form the double-network high-strength hydrogel through in-situ polymerization. The prepared infrared response high-strength hydrogel is high in biocompatibility and excellent in mechanical property and has good application prospects in the field of cartilago articularis repair.
Owner:SOUTHWEST JIAOTONG UNIV

Method for chondrocyte expansion with phenotype retention

The present invention provides a method that maintains chondrocyte phenotype during serial expansion by culturing a population of chondrocytes in a defined serum-free culture medium containing cytokines and on a substrate that is modified by covalent attachment of hyaluronic acid. The underlying principle is to maintain native chondrocyte phenotype by growing the dissociated chondrocytes on a substrate modified by covalent attachment of hyaluronic acid to retain native chondrocyte morphology and function. Chondrocyte expanded in this manner can be used in various medical applications to repair cartilaginous tissues that have been injured by trauma or disease. This substratum provides a microenvironment that more closely mimics that of native articular cartilage, thereby promoting chondrogenesis in a predictable manner.
Owner:ZIMMER INC +1

Health product for increasing bone density and preparation method of health product

InactiveCN104431684AImprove adsorption capacityStrong adsorption effect is stronger; 3) water holding capacityFood preparationRe absorptionIncreased Bone Density
The invention discloses a health product for increasing bone density and a preparation method of the health product. Chinese dwarf cherries, Chinese herbal medicine extracts refined by adopting a modern extraction technology and other raw materials having the function of increasing the bone density are scientifically compounded and are scientifically combined omnibearingly to play a synergistic effect, so as to effectively promote the calcium absorption in multiple aspects, repair and reconstruct the cartilago articularis, promote the generation of synovial fluid, promote the synthesis of collagen in cartilago articularis substrates, prevent the further degradation of cartilage, indirectly reduce the osteoclast function, inhibit the re-absorption of bones, increase the content of bone calcium and perfect the biomechanical properties of the bones, so that the product has a good function of increasing the bone density. A microwave drying technology in the preparation method can be used for further improving the integration and biological stability of the health product, and by means of the antioxidant activity of a grape seed extract in the raw materials, the strong adsorption and inclusion functions of modified dietary fibers and the antifungal propertie of the Chinese herbal medicine extracts, an efficient, safe, nutritional and stable health product having the function of increasing the bone density is prepared finally.
Owner:邵素英

Method for preparing functional gradient hydrogel for bone-cartilage repair

The invention discloses a method for preparing functional gradient hydrogel for bone-cartilage repair and belongs to the technical field of biological materials. Two parts of double-bond biomacromolecule pre-polymerization liquid with the same mass fraction are prepared firstly, then the pre-polymerization liquid is prepared into upper-layer cartilage repair pre-polymerization liquid containing repair factor nanoparticles and lower-layer subchondral bone repair pre-polymerization liquid containing calcium phosphorus nanoparticles, and based on suspension principle and optical polymerization reaction, the functional gradient hydrogel is formed through sedimentation and diffusion of nanoparticles, wherein the function of the functional gradient hydrogel changes along with the change of compositions and structure. The prepared bionic hydrogel has high biodegradability and biocompatibility, loaded growth factors are high in efficiency and slow release performance, cartilage and subchondral bone repair can be induced, bidirectional regeneration of bone-cartilage is achieved, and repair of cartilago articularis injuries is achieved.
Owner:SOUTHWEST JIAOTONG UNIV

Cartilago articularis vitrification cryoprotectant and cartilage preservation method

The invention discloses a cartilago articularis vitrification cryoprotectant and a cartilage preservation method. Each 1000ml of a vitrification cryoprotectant comprises 150-250ml of 99.9% dimethyl sulfoxide, 110-200g of acetamide, 70-120ml of 1,2-propylene glycol, 10-80g of polyethylene glycol, 20-100g of trehalose and the balance of deionized water. The cartilage preservation method comprises the following steps: soaking cartilage bone blocks at 4 DEG C by a gradient vitrification cryoprotectant sequentially for 10 minutes, packaging by a refrigerating pipe, putting into liquid nitrogen and storing; taking out before transplanting, rewarming, and carrying out water bath rewarming at 37 DEG C for 10 seconds; then putting cartilage bone blocks in a 10% saccharose solution and a 5% saccharose solution at 37 DEG C respectively, and remaining for 5 minutes; and finally washing by a phosphate buffer for 3 times so as to transplant and apply. According to the invention, the cartilago articularis tissues can be stored for a long time, the relatively high cell survival rate of cartilage is maintained, and the osteochondral graft preservation effect is enhanced; the cartilago articularis vitrification cryoprotectant and the cartilage preservation method are applied to the cartilage tissue library and the clinical cartilage transplantation.
Owner:TAISHAN MEDICAL UNIV

Non-virus nano nucleic acid transferring composite for curing gristle defection by injecting in joint cavity and preparing method thereof

The invention discloses a non-viral nanometer nucleic acid transportation compound used for treating cartilage defect through intra-articular injection which comprises low-molecular chitosan with molecular weight of 5KD-100KDand percentage composition of amino group of 30-70%, and nucleic acid, wherein N / P of the compound is 0.2:1-10:1.The invention degrades high molecular chitosan to low molecular chitosan, increases water solubility of material, reduces viscosity of solution, reduces influence of sour environment of solvent to cell, improves compound size with nanometer, is in favor of performing genetic transmission to cartilago articularis cell, and protects target nucleic acid from neutralizing with synovial fluid and being degrade by nuclease in lysosome. The invention has simple preparation and abroad application scope; can solve engineering roadblock of cartilage repair with no requirement of operation, complex device and bracket material.
Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A

Composition for increasing bone mineral density and preparation method of composition

InactiveCN104489699AImprove adsorption capacityStrong adsorption effect is stronger; 3) water holding capacityOrganic active ingredientsPeptide/protein ingredientsRe absorptionMechanical property
The invention discloses a composition for increasing bone mineral density and a preparation method of the composition. Chinese dwarf cherry, a Chinese herbal medicine extract refined by a modern extraction technology and other raw materials with the function of increasing the bone mineral density are scientifically compounded, are scientifically combined in an omnibearing manner, and work together, so as to achieve the effects of effectively promoting absorption of calcium from a plurality of aspects, restoring and rebuilding cartilago articularis, creating synovial fluid, and promoting collagen synthesis in the cartilago articularis, preventing cartilage from further degenerating, indirectly reducing osteoclast action, inhibiting re-absorption of bones, increasing bone calcium content and improving the mechanical property of the bone, so that the product has a good effect of increasing the bone mineral density. The integrating property and the biological stability of the composition can be further improved by a microwave drying technology in the preparation method. Due to the oxidation resistance of a grape pip extract in the raw materials, high adsorption and embedding effects of modified dietary fiber, and antifungal properties of the Chinese herbal medicine extract, the efficient, safe, nutrient and stable composition with the function of increasing the bone mineral density is finally prepared.
Owner:邵素英

Tissue engineering cartilago articularis in-vitro construction method and device

ActiveCN103525701AChange operabilityChanging the mode of static cultureApparatus sterilizationSkeletal/connective tissue cellsEngineeringSlide plate
The invention relates to a tissue engineering cartilago articularis in-vitro construction method and device. The device comprises a swing mechanism, a position adjusting mechanism, a cartilago articularis culture mechanism and a locating and connecting mechanism, wherein the swing mechanism comprises an indicator, a weight tray, a stabilizing rod, a swinging arm, a proximity switch, a sixth fastening screw, a left rotating shaft and a right rotating shaft. The position adjusting mechanism comprises a precision adjusting device, a left adjusting hand wheel, a left supporting plate, a left pressing plate, a first fastening screw, a left sliding plate, a shaft end cover, a right supporting plate, a control motor, a connecting key, the left rotating shaft, the right rotating shaft, a supporting base, a ninth fastening screw, an adjusting rod, a right pressing plate, a twelfth fastening screw, a right sliding plate, a right adjusting hand wheel, a right shaft connecting sleeve and a left shaft connecting sleeve. The construction method simulates a kinematic mechanics environment for in-vitro cartilago articularis, thus providing a method and a device which can apply pressure stress and friction force differing in frequency and weakness and can dynamically construct body cartilago articularis.
Owner:HANGZHOU BAIQIAO MEDICAL TECH CO LTD

Bionic cartilago articularis polyion complex hydrogel and preparation method thereof

The invention discloses a bionic cartilago articularis polyion complex hydrogel and a preparation method thereof. The hydrogel is prepared from the free radical polymerization reaction of a mixed solution of the following four materials: acrylic acid served as an anionic monomer, poly(sodium p-styrenesulfonate) served as an anionic polyelectrolyte, methyl acrylyl ethyl trimethyl ammonium chlorideserved as a cationic monomer and acrylic amide served as a neutral medium for supplying an oxygen-containing functional group. The invention utilizes a free radical polymerization method to prepare apolyion complex hydrogel within a short period of time; even if the prepared sample is radiated for 5min, the sample still shows excellent viscoelasticity; the hydrogel samples acquired within the scope of concentration all show excellent mechanical properties and biological friction performances; the adopted chemicals need not be specially treated; one-step preparation process is simple; the reaction condition is mild; the bionic cartilago articularis polyion complex hydrogel is suitable for large-scale production.
Owner:NANJING UNIV OF SCI & TECH

Comprehensive extracting process for collagen type II and chondroitin sulfate

The invention discloses a comprehensive extracting process for collagen type II and chondroitin sulfate. The comprehensive extracting process comprises the following steps of: using fresh cattle articular cartilages as raw materials; degreasing and de-calcifying the fresh cattle articular cartilages; dispersing the degreased and de-calcified fresh cattle articular cartilages into an acetic acid solution; performing enzymolysis and centrifuging the mixture to acquire liquid supernatant; salting out, dialyzing, freezing and drying the liquid supernatant to acquire collagen type II; dissolving precipitate acquired from centrifuging to a NaOH solution, and adding trypsin to the mixture; and de-coloring, ethanol- precipitating, dialyzing, freezing and drying the mixture after the enzymolysis at 40 DEG C to acquire the chondroitin sulfate. Collagen type II is the main organic component of a cartilage matrix, and is widely applied in the fields of tissue engineering, food and the like. The chondroitin sulfate widely exists in the cartilage tissues of the human and animals, has such functions of reducing blood fat, preventing tumors and the like, and has an extensive application prospect. According to the invention, bovine cartilage collagen type II and chondroitin sulfate are comprehensively used, so as to provide a novel idea for recycling waste.
Owner:SICHUAN UNIV

Preparation method of bionic porous tissue-engineered cartilage scaffold

The invention discloses a preparation method of a bionic porous tissue-engineered cartilage scaffold. The preparation method comprises the following steps: mixing a decellularized Whartons jelly suspension and chondroitin sulfate at the mixing ratio of the Whartons jelly suspension to chondroitin sulfate being 2.0:0.25-2.0:2.0, adding ethyl dimethylamine propyl carbide dimethylamine and fully uniformly mixing, and crosslinking at room temperature under the UV-irradiation of 258 nm wavelength 5-10 cm from a light source; putting a cross-linked scaffold into a cryogenic refrigerator to make the scaffold to be shaped, carrying out vacuum freeze drying to obtain a molded scaffold, storing the molded scaffold in a hermetic bag and sealing, disinfecting under irradiation at 60 DEG C, and preserving at 4 DEG C for standby. The prepared cartilage scaffold has bionic and porous characteristics, can induce stem cells in vitro to be differentiated to chondrocytes to promote expression of cartilage matrix components proteoglycan and collagen type II, can be used for in vitro construction of tissue-engineered cartilago articularis, and provides a high-quality scaffold material for repairing articular cartilage defects.
Owner:TAISHAN MEDICAL UNIV

A liquid-solid composite lubricant in joints and its preparation method

ActiveCN104383607BGood effect against cartilage damageReduce local symptomsSurgeryJoint cavityBiocompatibility Testing
The invention discloses an intra-articular liquid-solid composite lubricating agent and a preparation method thereof. The preparation method comprises the following steps: adding graphene oxide to sodium hyaluronate, so that the concentration is 20-50mu g / ml; carrying out ultrasonic treatment for 0.5-2 hours at 15-60 DEG C for evenly dispersing. The lubricating agent disclosed by the invention is safe and reliable, and good in cartilage damage resistance; a uniform lubricating film is formed on the surface of a joint, so that the friction damage on the joint is effectively reduced, the joint motion is increased, and the function of a knee joint is restored; meanwhile, the graphene oxide can stably exist in a joint cavity in a living body for a long period of time, has ultra-strong adsorbability and good biocompatibility, and has adsorption and slow-release effects on sodium hyaluronate, so that consumption of sodium hyaluronate is relieved; sodium hyaluronate is capable of protecting cartilago articularis; the local symptom of the knee joint is significantly reduced; the injection frequency is obviously reduced; at least one injection is changed from continuous injection once a week for five weeks in the past; and the pain caused by injection for a plurality of times is relieved.
Owner:天津中医药大学第一附属医院

Healthcare noodles with mantis shrimps and preparation method of healthcare noodles with mantis shrimps

The invention relates to healthcare noodles with mantis shrimps and a preparation method of the healthcare noodles with mantis shrimps. The healthcare noodles with mantis shrimps are prepared from the raw materials in percentage by weight according to a formula: 65-80% of flour, 5-10% of mantis shrimp enzymatic protein powder, 1.9-2.5% of glucosamine hydrochloride, 8-12% of zanthoxylum armatum DC leaves, 5-10% of sambucus williamsii leaves and 0.1-0.5% of abelmoschus manihot gum. All the raw materials are prepared into noodles through processing means with various approaches. Not only is the problem that mantis shrimp enzymatic protein powder can not be used as a food matrix because of having obvious bitter and fishy smells solved, but also the antibacterial, anticorrosion and fresh-keeping capacities of the noodles are also improved, and meanwhile, the healthcare value of the noodles is higher. In addition, the healthcare noodles with mantis shrimps is strong in fragrance, delicious in flavor, chewy, tough and elastic in chewing, good in boiling fastness and long in storage life. If being taken for a long term, the healthcare noodles with mantis shrimps can achieve the effects of regulating the physical function, resisting to diseases, bodybuilding and prolonging life and also have the effects of increasing the viscidity of synovial fluid, improving the cartilago articularis metabolism and strengthening tendons and bones. In addition, wastes are utilized comprehensively, so that the healthcare noodles with mantis shrimps have huge societal, ecological, environmental and economic benefits.
Owner:启东捷顺科技创业园有限公司

Nutritional composition beneficial for joint comfortableness as well as preparation method and application thereof

The invention belongs to the technical field of nourishment, and particularly relates to a nutritional composition beneficial for joint comfortableness as well as a preparation method and applicationthereof. The nutritional composition beneficial for the joint comfortableness is prepared from collagen powder, anti-inflammation material, a detumescence material and an emulsifier, wherein the anti-inflammation material is prepared from one or several of fish oil, olive oil, rhizoma curcumae longae and piperine; the swelling subsiding material is prepared from bromelain and / or papain. The nutritional composition disclosed by the invention is capable of relieving joint discomfort through nutritional intervention, balancing nutrition and achieving the effects of repairing cartilago articularis, removing inflammatory response, removing arthrocele, strengthening ligamenta and building muscles.
Owner:GUANGZHOU LIUYUAN PHARMA TECH

Chinese patent medicine for treating osteoarthritis and preparation method thereof

The invention belongs to the technical field of traditional Chinese medicines, relates to a Chinese patent medicine for treating osteoarthritis and a preparation method thereof. The Chinese patent medicine is prepared from the following raw materials in parts by weight: 5-10 parts of chondroitin sulphate sodium, 5-10 parts of glucosamine, 5-10 parts of burdock, 5-10 parts of salviae miltiorrhiza, 2-5 parts of eucommia ulmoides, 2-5 parts of earthworm, 2-5 parts of parasitic loranthus, 2-5 parts of radix achyranthis bidentatae, 2-5 parts of radix angelicae pubescentis, 2-5 parts of asarum, 2-5 root of largeleaf gentian, 2-5 parts of divaricate saposhnikovia root, 2-5 parts of ligusticum wallichii, 2-5 parts of dipsacus root, 2-5 parts of centipede, 2-5 parts of gastrodia elata and 2-5 parts of liquorice. The preparation method comprises the following steps: weighing raw materials in parts by weight; crushing into fine powder, sieving through an 80-100mesh sieve, and enclosing 0.6-0.7g of powder into each hollow capsule; and bottling and sealing. The traditional Chinese medicine components disclosed by the invention are capable of assisting the functions of chondroitin sulphate sodium and glucosamine for repairing cartilago articularis when developing the efficacy of strengthening muscles and bones; and the components of the traditional Chinese medicine and the Western medicine work together to quickly treat the osteoarthritis.
Owner:SHANDONG PROVINCIAL HOSPITAL

Intra-articular liquid-solid composite lubricating agent and preparation method

ActiveCN104383607AGood effect against cartilage damageReduce local symptomsSurgeryArticular surfacesJoint cavity
The invention discloses an intra-articular liquid-solid composite lubricating agent and a preparation method thereof. The preparation method comprises the following steps: adding graphene oxide to sodium hyaluronate, so that the concentration is 20-50mu g / ml; carrying out ultrasonic treatment for 0.5-2 hours at 15-60 DEG C for evenly dispersing. The lubricating agent disclosed by the invention is safe and reliable, and good in cartilage damage resistance; a uniform lubricating film is formed on the surface of a joint, so that the friction damage on the joint is effectively reduced, the joint motion is increased, and the function of a knee joint is restored; meanwhile, the graphene oxide can stably exist in a joint cavity in a living body for a long period of time, has ultra-strong adsorbability and good biocompatibility, and has adsorption and slow-release effects on sodium hyaluronate, so that consumption of sodium hyaluronate is relieved; sodium hyaluronate is capable of protecting cartilago articularis; the local symptom of the knee joint is significantly reduced; the injection frequency is obviously reduced; at least one injection is changed from continuous injection once a week for five weeks in the past; and the pain caused by injection for a plurality of times is relieved.
Owner:天津中医药大学第一附属医院

Application of Glycine tabacina (Labill.) Benth or extract thereof to preparation of drugs used for treating and/or preventing arthritis

The invention discloses an extract of Glycine tabacina (Labill.) Benth. The extract contains isoflavones, triterpenoids, scoparone and vanillic acid. The results of pharmacodynamic experiments show that the extract of Glycine tabacina (Labill.) Benth has obvious therapeutic effect on arthritis, can significantly reduce the degenerative changes of bones and destroy to cartilago articularis, decreases the expression of pro-inflammatory cytokines, inhibits oxidative stress, and provides a novel medication option for clinical treatment of arthritis.
Owner:UNIVERSITY OF MACAU

Preparation method of self-repairing bionic low-friction hydrogel cartilago articularis on basis of agar

The invention discloses a preparation method of self-repairing bionic low-friction hydrogel cartilago articularis on the basis of agar. The method includes the steps of adopting agar hydrogel as a physical cross-linking network and polyacrylic acid-polyacrylamide hydrogel as a chemical cross-linking network to form a double-layer network structure, and introducing iron ions to achieve a coordination effect with polyacrylic acid to prepare hydrogel with a porous aqueous structure. Dynamic reversible ionic coordination bonds and hydrogen bonds between the networks are utilized to endow the agar / polyacrylic acid-polyacrylamide-iron ion double network hydrogel with high self-repairing capability and mechanical performance. Compared with pure agar hydrogel, the agar / polyacrylic acid-polyacrylamide-iron ion double network self-repairing hydrogel cartilago articularis has the advantages that the compression modulus is increased by 80-120%, and good self-repairing performance is achieved.
Owner:NANJING UNIV OF SCI & TECH

Hydrogel capable of keeping high strength under physiological environment and preparation method thereof

The invention provides a hydrogel capable of keeping high strength under a physiological environment and a preparation method thereof. The method comprises the following steps: firstly, dissolving sodium silicate, acrylamide and sodium alginate in water; triggering acrylamide polymerization with ultraviolet rays; crosslinking with a calcium chloride solution in gradient concentration; in-situ generating calcium metasilicate nano-particles in the hydrogel; soaking the hydrogel in a gluconic acid-delta-lactone aqueous solution; hydrolyzing gluconic acid-delta-lactone and releasing hydrogen ions;generating calcium silicate with mesoporous silica gel on surface, through the reaction of hydrogen ions and calcium silicate. Hydrogen-bond interaction occurs between mesoporous silica gel and calcium alginate as well as polyacrylamide, so that the strength and stability under the physiological environment of the hydrogel are promoted. The strength is still kept above 70% of the initial value and the breaking energy is more than that of natural cartilage, after the hydrogel is soaked in normal saline or simulated body fluid for 45 days. The preparation method is simple and quick, no toxic reagent is introduced, and the material has excellent biocompatibility and can be used as a substitute of cartilago articularis.
Owner:深海奥创(舟山)科技有限公司

Glucosamine chondroitin sulfate calcium-adding tablet and preparation method

The invention discloses a glucosamine chondroitin sulfate calcium-adding tablet and a preparation method. The glucosamine chondroitin sulfate calcium-adding tablet contains 2-amino-2-deoxy-D-glucose,crabshell, shark cartilage powder, pig rib powder, collagen, dimethyl sulfone, calcium phosphate, calcium gluconate, goat milk calcium, magnesium stearate, xylitol, vitamins and functional peptides. The shark cartilage is added, the viscous polysaccharide rich in chondroitin in the shark cartilage can rebuild articular cartilage and is very helpful for cartilage degradation, and the crabshell hasthe functions of dispelling blood stasis, stopping bleeding and removing toxicity for detumescence. The natural calcium extracted from goat milk has high nutritional value, is easy to digest and absorb and high in absorption rate, does not stimulate the stomach, and does not cause any toxic side effects.
Owner:SHANDONG ZHUSHI PHARMA GRP CO LTD

Sole structure of high-heeled shoe, high-heeled shoe and manufacturing method of high-heeled shoe

The invention discloses a sole structure of a high-heeled shoe and the high-heeled shoe. The sole structure of the high-heeled shoe comprises a midsole and heightening platform assembly and an insole. A heightening platform and a midsole are connected to form the midsole and heightening platform assembly, a first convex block made of a damping material is arranged at the bottom of the part, making contact with the front foot sole, of the insole, and a groove for containing the first convex block is formed in the heightening platform. The high-heeled shoe with the sole structure further comprises a vamp, an outsole and a heel. The convex block is arranged at the bottom of the insole, the thickness of the damping material is increased, the damping rate is increased, the high-heeled shoe can protect the cartilago articularis and achieve the damping effect, and occupied space in the shoe is not increased; the thickness and shape of the damping material for filling are adjusted, and cost can be reduced to the maximum by adjusting the thickness of the damping material according to different heel differences; stress can be evenly dispersed through the first convex block in arc transition, and therefore the foot sole feels the same softness in all directions.
Owner:傅新生

Articular cavity extracellular matrix polysaccharide nanometer injection and preparation method thereof

InactiveCN106075408ABroad physiological functionsStrong osteoinductive abilityOrganic active ingredientsPowder deliveryCell-Extracellular MatrixECM Protein
The invention belongs to the field of biological materials, and particularly relates to an articular cavity extracellular matrix polysaccharide nanometer injection and a preparation method thereof. The injection is prepared from, by weight, 1-4% of sodium hyaluronate, 2-5% of collagen, 0.5-1.5% of human bone morphogenetic proteins, 0.2-3% of chondroitin sulfate, 0.1-1% of heparin sulfate, 1-4% of glucosamine sulfate, 0.1-5% of chitosan, 0.2-0.8% of isoosmotic adjusting agent, a pH regulator and deionized water. Due to the addition amount of the pH regulator, the pH of the injection is 6.0-7.0. The prepared injection can effectively protect cartilago articularis and has a slow-release anti-inflammatory effect.
Owner:上海建华精细生物制品有限公司

A kind of hydrogel which maintains high strength under physiological environment and preparation method thereof

The invention provides a hydrogel capable of keeping high strength under a physiological environment and a preparation method thereof. The method comprises the following steps: firstly, dissolving sodium silicate, acrylamide and sodium alginate in water; triggering acrylamide polymerization with ultraviolet rays; crosslinking with a calcium chloride solution in gradient concentration; in-situ generating calcium metasilicate nano-particles in the hydrogel; soaking the hydrogel in a gluconic acid-delta-lactone aqueous solution; hydrolyzing gluconic acid-delta-lactone and releasing hydrogen ions;generating calcium silicate with mesoporous silica gel on surface, through the reaction of hydrogen ions and calcium silicate. Hydrogen-bond interaction occurs between mesoporous silica gel and calcium alginate as well as polyacrylamide, so that the strength and stability under the physiological environment of the hydrogel are promoted. The strength is still kept above 70% of the initial value and the breaking energy is more than that of natural cartilage, after the hydrogel is soaked in normal saline or simulated body fluid for 45 days. The preparation method is simple and quick, no toxic reagent is introduced, and the material has excellent biocompatibility and can be used as a substitute of cartilago articularis.
Owner:深海奥创(舟山)科技有限公司

Application of LCA in preparation of drug for treating joint inflammation or cartilago articularis and bone destruction

The invention relates to an application of LCA (9, 9'-O-bi-(E)-feruloylated-meso-5, 5'-dimethoxy secoisolariciresinol) in preparation of drug for treating arthritis or cartilago articularis and bone destruction. By using a cell heat transfer technology, the compound LCA can be combined with MEK1 protein and cathepsinK protein in cells, animal tests verify that the LCA can improve the symptoms of a rat with rheumatoid arthritis and the research results show that LCA has a double target effects of simultaneously inhibiting immune inflammation and preventing and treating bone destruction and has a board application prospect in clinical treatment of diseases such as rheumatoid arthritis, osteoarthritis, osteoporosis and the like.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Composite hydrogel as well as preparation method and application thereof

The invention discloses composite hydrogel as well as a preparation method and application thereof. The composite hydrogel is prepared from methacrylate sulphobetaine, ethylene glycol dimethacrylate and glyceryl polyether through free radical polymerization and ester exchange reaction. According to the invention, GE is introduced into PSBMA hydrogel, new chemical crosslinking is generated through transesterification, a composite hydrogel network GE-PSBMA is formed, compared with pure PSBMA hydrogel, the GE-PSBMA composite hydrogel has the advantages that the compressive strength is obviously enhanced and is increased by nearly 40 times, the composite hydrogel has a low friction coefficient, and the composite hydrogel shows relatively good biocompatibility, hydrophilicity and thermal stability, and can be applied to the field of biomedical materials. The material has potential to become an articular cartilage substitute material.
Owner:BEIJING JIAOTONG UNIV

Mantis shrimp health noodles and preparation method thereof

The invention relates to healthcare noodles with mantis shrimps and a preparation method of the healthcare noodles with mantis shrimps. The healthcare noodles with mantis shrimps are prepared from the raw materials in percentage by weight according to a formula: 65-80% of flour, 5-10% of mantis shrimp enzymatic protein powder, 1.9-2.5% of glucosamine hydrochloride, 8-12% of zanthoxylum armatum DC leaves, 5-10% of sambucus williamsii leaves and 0.1-0.5% of abelmoschus manihot gum. All the raw materials are prepared into noodles through processing means with various approaches. Not only is the problem that mantis shrimp enzymatic protein powder can not be used as a food matrix because of having obvious bitter and fishy smells solved, but also the antibacterial, anticorrosion and fresh-keeping capacities of the noodles are also improved, and meanwhile, the healthcare value of the noodles is higher. In addition, the healthcare noodles with mantis shrimps is strong in fragrance, delicious in flavor, chewy, tough and elastic in chewing, good in boiling fastness and long in storage life. If being taken for a long term, the healthcare noodles with mantis shrimps can achieve the effects of regulating the physical function, resisting to diseases, bodybuilding and prolonging life and also have the effects of increasing the viscidity of synovial fluid, improving the cartilago articularis metabolism and strengthening tendons and bones. In addition, wastes are utilized comprehensively, so that the healthcare noodles with mantis shrimps have huge societal, ecological, environmental and economic benefits.
Owner:启东捷顺科技创业园有限公司

Polypeptides regulating fgfr1 activity and applications thereof

The invention discloses a polypeptide R1-P1 for adjusting FGFR1 (Fibroblast Growth Factors Receptor 1) activity. The polypeptide can be combined with the FGFR1 specificity, has an obvious adjusting function for the FGFR1 activity and can obviously restrain the activity of p-ERK in the main downstream signal path MAPK of FGFR1; after the R1-P1 peptide is articular injected to DMM model mouse, the regression of cartilago articularis and the loss level of matrix are obviously reduced; the process of arthritis is delayed. The polypeptide has the advantages of small molecular weight, simple preparation, controllable quality, low immunogenicity, and the like, can be used for preparing the drugs for relieving or treating osteoarthritis and has an excellent potential application value.
Owner:THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA

Cereal powder for repairing scoliosis and preparation method thereof

InactiveCN112841629AAchieve fixStrong expelling wind and analgesiaAntipyreticAnalgesicsConnective tissue fiberCapillary hyperpermeability
The present invention discloses a cereal powder for repairing scoliosis, and particularly relates to the technical field of cereal. The cereal powder comprises a phase A component and a phase B component. The phase A component comprises the following components: ganoderma lucidum, blueberry and black sesame; and the phase B component consists of the following components: white sesames, soybeans, oats, peanuts, ginseng, caulis spatholobi, pseudo-ginseng, ligusticum wallichii, peach kernels, safflower carthamus, radix paeoniae rubra, radix salviae miltiorrhizae, trogopterus dung and rhizoma drynariae. The processed cereal powder has relatively strong synergistic effects of dispelling wind and easing pain, clearing and activating the channels and collateral, warming channels and tonifying yang, and enhancing synergistic effect among elements such as calcium, phosphorus and iron, improves metabolism of connective tissues and permeability of capillary vessels, promotes transformation and absorption of hyperplasia lesions and fading of focus tissues, and repairs atrophic connective tissues. In addition, the cereal powder can repair a damaged cartilago articularis platform, relieve pain, improve rigid joints, and recover the elasticity, obtains stable softness again, and repairs scoliosis.
Owner:胡其勇

Retractable brush for arthroscope

The invention discloses a retractable brush for an arthroscope. The retractable brush comprises a brush head, a brush handle and a casing tube; the brush head is arranged at the front end of the brushhandle; the inner diameter of the casing pipe is greater than the outer diameter of the brush handle, the casing tube sleeves the brush head and the brush handle, and the length of the casing tube isgreater than or equal to that of the brush head. The retractable brush is convenient to operate. Compared with conventional planing cutter heads and radio frequency vaporization cutter heads, the retractable brush has the advantages that not only can diseased tissue on the surface of a joint be removed to the maximum extent, but also the cartilago articularis cannot be damaged, and convenience isprovided for the brush to get in or get out of a micro incision.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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