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Bionic cartilago articularis polyion complex hydrogel and preparation method thereof

A bionic joint and polyion technology, which is applied in tissue regeneration, prosthesis, medical science, etc., can solve problems hindering industrial scale production, achieve good mechanical properties and bio-friction properties, mild reaction conditions, and simple preparation process.

Active Publication Date: 2018-12-11
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Sun et al. used a two-step method to sequentially polymerize both cationic and anionic monomers into hydrogels, which exhibited high strength and high toughness, but their production on an industrial scale was hampered by the step-by-step approach.

Method used

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  • Bionic cartilago articularis polyion complex hydrogel and preparation method thereof
  • Bionic cartilago articularis polyion complex hydrogel and preparation method thereof
  • Bionic cartilago articularis polyion complex hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Prepare an AA solution with a volume fraction of 20% (v / v), which contains 1mol / L AAm.

[0035] (2) 30% (v / v), 0.1% (v / v) and 0.4% (v / v) of MTAC, photoinitiator and crosslinker were added to the solution obtained in step 1, respectively, in the volume ratio of AA , and then placed on a magnetic stirrer, and stirred until it was colorless and transparent.

[0036] (3) The solution obtained in (2) was poured into a mold consisting of two parallel glass plates and a silicone ring (the outer side of the silicone ring was coated with vaseline to prevent the solution from seeping out), and the four sides were clamped with clips, and placed in a self-made UV lamp (Wavelength range 200~2500nm, including ultraviolet part) irradiation for different time: 5min, 10min, 15min, 20min.

[0037] (4) The hydrogel sample obtained in (3) was dialyzed in a large amount of deionized water to remove residual monomers and cross-linking agents and other impurities.

[0038] figure 1 The...

Embodiment 2

[0042] (1) Prepare an AA solution with a volume fraction of 20% (v / v), which contains 1mol / L AAm.

[0043] (2) MTAC and PSS with a volume ratio of 30% (v / v) of AA, photoinitiators and crosslinkers with a volume ratio of 0.1% (v / v) and 0.4% (v / v) of AA, respectively Add it to the solution obtained in step 1, then place it on a magnetic stirrer, and stir until it is colorless and transparent.

[0044] (3) The solution obtained in (2) was poured into a mold consisting of two parallel glass plates and a silicone ring (the outer side of the silicone ring was coated with vaseline to prevent the solution from seeping out), and the four sides were clamped with clips, and placed in a self-made UV lamp (Wavelength range 200~2500nm, including ultraviolet part) irradiation for different time: 5min, 10min, 15min, 20min.

[0045] (4) The hydrogel sample obtained in (3) was dialyzed in a large amount of deionized water to remove residual monomers and cross-linking agents and other impuritie...

Embodiment 3

[0053] (1) Prepare an AA solution with a volume fraction of 20% (v / v), which contains 1mol / L AAm.

[0054] (2) MTAC and PSS that account for 20%, 30%, and 40% (v / v) of AA by volume (PSS content is consistent with MTAC), and 0.1% by volume of AA (v / v) , 0.4% (v / v) photoinitiator and cross-linking agent were added to the solution obtained in step 1, then placed on a magnetic stirrer, and stirred in shading until a colorless and transparent state appeared.

[0055] (3) The solution obtained in (2) was poured into a mold consisting of two parallel glass plates and a silicone ring (the outer side of the silicone ring was coated with vaseline to prevent the solution from seeping out), and the four sides were clamped with clips, and placed in a self-made ultraviolet lamp (wavelength range 200~2500nm, including ultraviolet part) irradiation for 15min.

[0056] (4) The hydrogel sample obtained in (3) was dialyzed in a large amount of deionized water to remove residual monomers and cro...

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Abstract

The invention discloses a bionic cartilago articularis polyion complex hydrogel and a preparation method thereof. The hydrogel is prepared from the free radical polymerization reaction of a mixed solution of the following four materials: acrylic acid served as an anionic monomer, poly(sodium p-styrenesulfonate) served as an anionic polyelectrolyte, methyl acrylyl ethyl trimethyl ammonium chlorideserved as a cationic monomer and acrylic amide served as a neutral medium for supplying an oxygen-containing functional group. The invention utilizes a free radical polymerization method to prepare apolyion complex hydrogel within a short period of time; even if the prepared sample is radiated for 5min, the sample still shows excellent viscoelasticity; the hydrogel samples acquired within the scope of concentration all show excellent mechanical properties and biological friction performances; the adopted chemicals need not be specially treated; one-step preparation process is simple; the reaction condition is mild; the bionic cartilago articularis polyion complex hydrogel is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a polyion complex hydrogel and a preparation method thereof. Background technique [0002] Articular cartilage is extremely vulnerable to damage due to physical trauma or osteoarthritis, but the lack of nerves and blood vessels inside cartilage tissue, as well as potential stem cells / chondrocyte progenitor cells, limits the ability of cartilage to repair itself. Current research in cartilage repair has focused on synthetic articular cartilage replacements or biomaterials that stimulate regeneration of new tissue. Hydrogels can be used as articular cartilage repair materials due to the following two reasons: excellent biocompatibility; properties similar to natural cartilage, such as similar structure, swelling properties and viscoelasticity. The hydrogels used to repair articular cartilage mainly include: polyvinyl alcohol hydrogel, hyaluronic acid gel, alginate gel,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F257/00C08F220/06C08F220/34C08F220/56C08F2/48A61L27/16A61L27/52
CPCA61L27/16A61L27/52A61L2430/06C08F2/48C08F257/00C08F220/06C08F220/56C08F220/34C08L51/003
Inventor 熊党生熊潇雅周亭飞刘昀彤
Owner NANJING UNIV OF SCI & TECH
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