79 results about "Articular cartilage repair" patented technology

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair / regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

An implant for articular cartilage repair includes (1) a three-dimensional body formed of cancellous bone having a demineralized section that contains bone morphogenetic proteins (BMP's) that are released by the demineralization but retained in the body, and (2) a cartilage layer formed on a surface of the demineralized section. The cartilage layer is formed by a method including the steps of (a) isolating chondrocytes from articular cartilage of a donor; (b) cultivating the isolated chondrocytes in a medium; (c) adding the cultivated chondrocytes to the demineralized section of the body, whereby the cultivated chondrocytes are stimulated by the BMP's retained in the body; and (d) incubating the cultivated chondrocytes to form a plurality of layers of chondrocytes on the demineralized section, wherein the plurality of layers of chondrocytes forms the cartilage layer.

The invention relates to a substitute material for rehabilitating articular cartilage and a preparation method thereof. A substitute material body is a porous hydrogel structural body with an interpenetrating network structure polymerized by PVA and PVP type components; the mass ratio of polyvinyl alcohol to pyrrolidone type components is 1: (0.01 to 1); and the elastic modulus is 0.5 to 10 MPa. The substitute material is prepared by adopting an in-situ solution polymerization method and the preparation method comprises the following steps: dissolving the monomers of the PVP type components in PVA solution and mixing completely and uniformly; adding a free radical initiator and polymerizing to obtain a blending system of the PVP type components; then adding a cross-linking agent to continuously carry out cross-linking polymerization reaction to obtain a hydrogel product; and finally preparing the substitute material through repeatedly freezing / unfreezing till the hardness reach the expected index. The substitute material is of a porous structure with an interpenetrating network which can contain a large amount of water and is a permeable material; liquid can be permeated and extruded as a lubricant under the load action; and furthermore, the substitute material has good mechanical strength approximate to the mechanical property of the articular cartilage, is similar to natural cartilage tissues, and has good biological compatibility.

Embodiments of the invention concern the regeneration of chondrocytes and cartilage-type cells. In certain embodiments, one or more genes are employed for the regeneration of chondrocytes and ca1iilage-type cells. In particular embodiments, one or more gene therapy regimens are employed for the regeneration of chondrocytes and cartilage-type cells. In particular aspects, embodiments concern cartilage repair, such as articular cartilage repair. More particularly, embodiments for the disclosure concern using gene therapy for the attraction, generation and / or regeneration of chondrocytes or other cartilage-type cells and / or the generation and / or repair of cartilage tissue. In specific embodiments of the disclosure, gene therapy is provided that is capable of attracting and / or generating desired cells in vivo.