301 results about "Intermolecular interaction" patented technology

The invention relates to a method for identifying in a sample molecules with the capacity to bind to the different members of a molecule library, wherein the molecules which are in the sample are fractionated based on a physicochemical property of the sample and subsequently transferred from the support in which said molecules have been separated to a second support in which the different members of the molecule library are grouped into microarrays such that they uniformly coat the surface of the support. This technique is especially interesting for the identification in a sample of glycoproteins with affinity for a lectin library as well as for the identification of compounds capable of modulating the glycosylation of proteins and for the rapid characterization of alterations in the glycosylation pattern of a sample of proteins, which can be useful in the diagnosis of diseases in which there are alterations in cell glycosylation.

The invention discloses a method for preparing functional soluble and edible compound membranes. The method is characterized in that the functional soluble and edible compound membranes are made of polysaccharides, proteins and starch and further comprises membrane-forming agents, reinforcing agents, plasticizers, cross-linking agents, antioxidants and gelatin, and the membrane-forming agents, the reinforcing agents, the plasticizers, the cross-linking agents and the antioxidants are used as auxiliary materials; the method includes steps of mixing aqueous solution, stirring and homogenizing the aqueous solution to obtain aqueous solution A or mixed aqueous solution B and allowing the aqueous solution A or the mixed aqueous solution B to stand still for standby application; carrying out heating treatment to obtain uniform thin membranes by means of flow-casting and cutting and packaging the compound membranes to obtain finished products. The method has the advantages that the functional soluble and edible compound membranes which are of porous network structures can be formed under the mutual effects of different molecules, have certain strength but are soft, can be dissolved in hot water but are moisture-resistant at normal temperature, can be subjected to heat-seal, are edible and are beneficial and harmless to the health, and the method can be widely applied to the field of food packaging.

The invention discloses supramolecular polymer clean fracturing fluid resistant to high temperature of 170 DEG C. The fracturing fluid is prepared from the following components in percentage by weight: 0.2 to 0.5 percent of thickening agent for the clean fracturing fluid, 0.1 to 0.5 percent of viscosity synergist, 0.2 to 0.4 percent of structural intensifier, 0.05 to 0.2 percent of deoxidant, 0.1 to 0.3 percent of metal ion chelating agent, 1 to 2 percent of clay stabilizer and the balance of fresh water. According to the clean fracturing fluid, a reversible supramolecular network structure is formed through the intermolecular interaction, and the thickening agent is low in use concentration and can be used for effectively controlling the viscosity of a base solution of the fracturing fluid and improving the pumping performance of the fluid; viscoelastic sand-carrying of the fracturing fluid is realized by low viscosity and high viscoelasticity; the temperature resistance can reach 170 DEG C under a long-term shear condition; the shear resistance is excellent, and the fluid viscosity and the structure after high shear can be effectively recovered; the construction friction is low, and the equipment load and the fracturing construction risk are reduced; the residue content is low, so that the damages to a reservoir stratum and prop fractures are greatly reduced, and the fracturing stimulation effect is greatly improved.

The present invention provides a method of minimizing absorption of visible light in an ink composition comprising an IR-absorbing macrocyclic cyanine dye, comprising preselecting said dye such that it includes at least one moiety for reducing intermolecular interactions between adjacent dye molecules. The method is especially suitable for use in connection with netpage and Hyperlabel systems.

The invention belongs to the field of articular cartilage repair materials, and provides a preparation method and application of high strength and porous structure polyvinyl alcohol-gallotannic acid hydrogel. The hydrogel is a potential articular cartilage replacement material. According to the preparation method, polyvinyl alcohol is adopted as a substrate material, the ice crystal forming ability of a hydrogel precursor solution is improved by introducing gallotannic acid and microbubbles, and meanwhile, the mechanical property of the hydrogel is greatly enhanced due to the intermolecular interaction between the gallotannic acid and the polyvinyl alcohol. The porous structure and high strength hydrogel is prepared at one step, the preparation process is simple, repeatability is high, theobtained hydrogel has good biocompatibility, meets a porous environment for adhesion and proliferation of cartilage cells and the mechanical property similar to natural articular cartilage, and can be applied to the field of articular cartilage replacement materials.

The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.

The invention relates to an organic second-order non-linear optical chromophore with a D-Pi-A structure and decorated by a tree-like group, and a synthesizing method and applications thereof. The chromophore of the invention introduces a thiophene ring conjugated Pi electronbridge having stronger electrical transmission capacity and containing branched chains and a tricyano pyrroline receptor having strong electron-withdrawing property; the receptor end is introduced into the tree-like decorative group, the one-order hyperpolarizability of chromophore molecules is greatly improved; the solubility and the film forming ability of the chromophore in polymer is improved, the interaction force among the molecules is reduced. The second-order non-linear optical chromophore with the following structure is doped with polymers, such as amorphous polycarbonate or polymethylmethacrylate and the like according to the mass ratio of 1:10; the electro-optical coefficient of the obtained polarized polymeric materials achieves 217pm/V; in addition, the donor and receptor of the chromophore can be introduced into a crosslinkable group, thus improving oriented stability of the chromophore in polymer, and satisfying the requirements of devices.

The present invention belongs to the field of polymer materials and biomedical engineering, and particularly relates to a polylactic acid stereo complex magnetic nanometer vesicle preparation method, which specifically comprises that: L-polylactic acid and D-polylactic acid respectively react with polyethylene glycol to synthesize two different block copolymers, then stereo compounding is performed, and nanometer magnetic particles are entrapped so as to form the polylactic acid stereo complex magnetic nanometer vesicle adopting the hydrophobic stereo composite polylactic acid as the film and having the inner layer and the outer layer being the hydrophilic polyethylene glycol chains, wherein the obtained nanometer vesicle has excellent stability due to the strong intermolecular interaction of the stereo complex, and the magnetic particles are wrapped in the compact polylactic acid film structure so as not to be easily leaked. According to the present invention, the magnetic nanometer vesicles can be used as the enhancement contrast agent in the clinical magnetic resonance imaging, and can further load drugs or biological macromolecules so as to be used as the release controlling nanometer carrier of drug or gene therapy.

The invention discloses a S,S-dioxo-dibenzothiophene unit-containing electron donor polymer and a use thereof. The main chain of the S,S-dioxo-dibenzothiophene unit-containing electron donor polymer contains a S,S-dioxo-dibenzothiophene unit. Through Stille and Suzuki polymerization methods, a novel D-A structure conjugated polymer is constructed. The S,S-dioxo-dibenzothiophene unit has good flatness and high electronegativity. Through the S,S-dioxo-dibenzothiophene unit, the polymer has a deep HOMO energy level, strong intermolecular interaction, a high light-absorption coefficient, high mobility and high photoelectric response so that the related polymer has wide application prospects in solar cells or organic field effect transistors.

Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.

Belonging to the technical field of macromolecular functional materials and organic electronics, the invention provides a macromolecular compound containing boron-nitrogen coordinate bond, a preparation method and application thereof, and solves the technical problem of low mobility of organic conjugated macromolecular compounds in the prior art. The conjugated main chain of the macromolecular compound provided by the invention contains three fragments, namely an electron-deficient double boron-nitrogen coordinate bond bridged bipyridyl unit, an Ar unit and an electron-rich thiophene unit respectively, and the structural formula is shown as formula (I). The macromolecular compound has the characteristics of good planarity, strong crystallinity, strong intermolecular interaction, etc., andcan greatly improve the electron mobility of the material; the chemical structure is easy to modify, the energy level structure is adjustable, and the absorption spectrum is wide; and the macromolecular compound can be applied as the acceptor material of organic solar cells and the charge transport layer material of organic field effect transistors.

It is an object of the present invention to provide a fluorescent indicator that is based on homo FRET (fluorescence resonance energy transfer) using fluorescent molecules with a small stokes' shift, thereby developing a visualization system for intermolecular interaction. The present invention provides a fluorescent indicator formed by fusing fluorescent molecular components having substantially identical fluorescent properties to the N- and C-terminal sides of a target sequence, to which an analytical substance binds or reacts, so as to change the three-dimensional structure of the indicator.

The present invention provides an IR-absorbing metal-cyanine dye, said metal having at least one axial ligand bound thereto, wherein said axial ligand comprises a moiety suitable for reducing intermolecular interactions between adjacent dye molecules, thereby minimizing absorption of visible light. Dyes of this type are especially suitable for use in netpage and Hyperlabel systems.

The present invention provides, in the use of the energy transfer phenomenon in a detection system for the measurement of the concentration of a material, a method for controlling the spatial arrangement of an energy donor and an energy acceptor in a reaction complex in order to carry out the measurement with good precision and high sensitivity, and a measurement system using the method. Two types of material having affinity for the subject material to be measured are respectively labeled with a combination of reporters that give rise to energy transfer; those that have been thus obtained by labeling these materials are each further labeled with materials that have weak affinity for each other to give reagents, which are then mixed with a sample to give the reaction complex. Each of the materials is brought into spatial proximity by binding based on the affinity among the materials having weak affinity for each other in the reaction complex, and since that condition is stably maintained, a more efficient energy transfer occurs.