253 results about "Supramolecular assembly" patented technology

The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. It has been determined that the inclusion of the hydrophobic co-monomers to the polyelectrolyte segment forming the micelle core leads to a structure of enhanced stability.

The invention discloses a supramolecule assembly of targeting-delivery anticancer adamplatin. The supramolecule assembly is a binary supramolecule assembly which is synthesized on the basis of cyclodextrin-decorated hyaluronic acid and adamplatin. A preparation method of the supramolecule assembly is characterized in that the cyclodextrin-decorated hyaluronic acid and the adamplatin are respectively synthesized, and through the strong non-covalent interaction of cyclodextrin and adamantine and the amphiphilic action of molecules, a supermolecule nano particle which takes the hydrophilic hyaluronic acid as a shell and the adamplatin as a core is formed. The supramolecule assembly disclosed by the invention has the advantages that the supramolecule assembly of the targeting-delivery anticancer adamplatin has a simple synthetic route, is low in preparation cost and high in productivity, and is suitable for amplification synthesis and practical production application; and through endocytosis in which a malignant cell surface hyaluronic acid receptor serves as a medium, the supramolecule assembly (HAP) is brought in cancer cells in a target manner, so that the protection of normal cells and the targeting selective killing of cancer cells are realized, the anti-cancer activity is obviously improved, and toxic and side effects are obviously reduced.

The present invention generally relates to supramolecular assemblies and their modes of synthesis. The supramolecular assemblies include a 1:8 ratio of a supermolecular polyhedral building block and a triangular molecular building block, the supermolecular polyhedral building block having points of extension corresponding to the vertices of a rhombicuboctahedron for linking the supermolecular polyhedral building block to the triangular building block.

Modification of a unique supramolecular assembly of a pyridylphosphine ligand and a metal centered porphyrin complex is shown to give unprecedented selectivities to branched aldehydes via rhodium catalyzed hydroformylation of propylene and 1-octene. Use of magnesium in the porphyrin center provides the highest reported concentrations of iso-butyraldehyde and 2-methyl-octanal.

An optical device that comprises an input waveguide, an output waveguide, a high-Q resonant or photonic structure that generate slow light connected to the input waveguide and the output waveguide, and an interface, surface or mode volume modified with at least one material formed from a single molecule, an ordered aggregate of molecules or nanostructures. The optical device may include more than one input waveguide, output waveguide, high-Q resonant or photonic structure and interface, surface or mode volume. The high-Q resonant or photonic structure may comprise at least one selected from the group of: microspherical cavities, microtoroidal cavities, microring-cavities, photonic crystal defect cavities, fabry-perot cavities, photonic crystal waveguides. The ordered aggregate of molecules or nanostructures comprises at least one selected from the group of: organic or biological monolayers, biological complexes, cell membranes, bacterial membranes, virus assemblies, nanowire or nanotube assemblies, quantum-dot assemblies, one or more assemblies containing one or more rhodopsins, green fluorescence proteins, diarylethers, lipid bilayers, chloroplasts or components, mitochondria or components, cellular or bacterial organelles or components, bacterial S-layers, photochromic molecules. Further, the molecular aggregate may exhibit a photoinduced response.

The invention pertains to the technical field of nanometer supramolecular materials, and relates to a nanometer supramolecular assembly of a perylene diimide derivate modified by full methylated Beta-cyclodextrin loaded by polyvinylidene fluoride membrane and a preparation method thereof. The chemical formula of the molecular assembly is C138H226N2O72, and the structure thereof is shown as in an attached drawing. The perylene diimide derivate modified by the red fully methylated Beta-cyclodextrin is dissolved to obtain the nanometer supramolecular assembly. The method adopts the strong fluorescence of solid perylene as a detecting singnal, takes an empty chamber of the fully methylated Beta-cyclodextrin as a receptor of an air molecule, thereby solving two difficulties of strong fluorescence in a solid state in the construction of a fluorescence sensor and the introduction of a suitable air molecular receptor. The nanometer supramolecular assembly of the perylene diimide derivate modified by full methylated Beta-cyclodextrin loaded by PVDF member realizes quick detection of the fluorescence sensing function of the air molecules of nitromethane, nitroethane and nitrobenzene in 10s.

The present invention generally relates to supramolecular assemblies and their modes of synthesis. The supramolecular assemblies include a 1:8 ratio of a supermolecular polyhedral building block and a triangular molecular building block, the supermolecular polyhedral building block having points of extension corresponding to the vertices of a rhombicuboctahedron for linking the supermolecular polyhedral building block to the triangular building block.

A method for preparing an extended conjugated molecular assembly includes applying onto a surface of a substrate a first molecular compound G1-Molecule1-G2, where G1 includes a first functional group, G2 includes a second functional group, and Molecule1 includes a conjugated organic group bonded to G1 and G2, and reacting the first molecular compound with a second molecular compound G3-Molecule2-G4, where G3 includes a third functional group. G4 includes a fourth function group, and Molecule 2 includes a conjugated organic group bonded to G3 and G4, to form on the substrate an extended conjugated molecule G1-Molecule1-Molecule2-G4.

The invention relates to a preparation method of a supermolecular nanometer aggregate with triple responses of temperature, UV (ultraviolet) and reducing agent. The preparation method comprises the following steps of using a beta-cyclodextrin-modified thermo-sensitive copolymer (beta-CD-P(MEO2MA-co-OEGMA)) as a host molecule, and using an azobenzene-terminated amphiphilic blocking copolymer (Azo-PCL-SS-PEG) as a guest molecule, and building a supermolecular assembly with a mutual electrostatic action of the host molecule and the guest molecule; using a sulfonation and bromination product of the beta-cyclodextrin to initiate ATRP (atom transfer radical polymerization) reaction, so as to obtain the host molecule; using chain-extended 4-hydroxyazobenzene to open a loop of caprolactone, and performing a two-step esterification reaction, so as to obtain the guest molecule; respectively dissolving the host molecule and the guest molecule into water, and uniformly mixing, so as to obtain a supermolecular self-assembly micellar solution. The preparation method has the advantages that by applying outside irritation to the system, the shape and size of the micelle can be reversibly and controllably transformed; the application prospect in the fields of medicine loading and controllable release, biological intelligent switches, nanometer intelligent reactors and the like is wide.

The invention discloses a targeted transmission assembly of an adriamycin anticancer medicine. The targeted transmission assembly is a ternary supermolecular assembly synthesized by using graphene oxide, folic acid modified cyclodextrin compound and adamantine modified porphyrin compound. The preparation method comprises: synthesizing folic acid modified beta-cyclodextrin and adamantine modified porphyrin respectively, absorbing the folic acid modified beta-cyclodextrin onto the graphene oxide under pi-pi action by using porphyrin as a medium, introducing folic acid onto the surface of graphene by using the strong noncovalent action of the adamantine and beta-cyclodextrin, and preparing the assembly by using the surface of the graphene oxide as the carrier of the pi-system adriamycin anticancer medicine. The invention has the advantages that: the synthesis route of the targeted medicine transmission assembly is simple, the yield of the targeted medicine transmission assembly is high, and the targeted medicine transmission assembly is suitable for amplified synthesis and use in actual production; and the assembly 1 / 2 / DOX / GO is brought into a targeted cancer cell under endocytosis with a folic acid receptor in a malignant cell as a medium, so that the protection of normal cells and the targeted selective killing of cancer cells are realized.

The invention provides a method for separating a mixture of 2, 4-dichlorophenol and 2, 5-dichlorophenol. Based on the fundamental principle of supramolecular assembly, the method uses topology match between subjective molecules and objective molecules, and separates 2, 4 / 2, 5-mixed dichlorophenol by identifying molecules. Because of different molecular spatial structures of the 2, 4-dichlorophenol and the 2, 5-dichlorophenol and certain difference on polarities, specific different identifying capability among the subjective molecules exists, while difficulty or ease of intermolecular actions among the subjective molecules and other heterocyclic compound is different, therefore, the aim of separation can be achieved through identifying the molecules. The product obtained from the 2, 4 / 2, 5-mixed dichlorophenol by the method has high purity, and can be directly used after being separated, but does not need to be recrystallized to improve purity; and the method has high yield, is simple and practical, and is easy to industrialize.

The invention provides a fluorescent nanoparticle solution. A building unit of the fluorescent nanoparticle uses sulfonato calix[4]arene derivative as the host and tetraphenylethylene quaternary ammonium salt as the guest. A supramolecular assembly is built through interactions of inclusion and complexation of the host-guest among the building units. The sulfonato calix[4]arene derivative is a single-bridged sulfonato calix[4]arene containing a sulfonato calix[4]arene unit or double-bridged sulfonato calix[4]arene containing two sulfonato calix[4]arene units. A preparation method provided by the invention is as follows: tetraphenylethylene quaternary ammonium salt is firstly prepared, and then tetraphenylethylene quaternary ammonium salt and sulfonato calix[4]arene derivative are dissolved into water and mixed uniformly to obtain the final product. The fluorescent nanoparticle solution provided by the invention has the advantages that: (1) the nanoparticle has the specific gathered fluorescence emission characteristic of tetraphenylethylene and the tetraphenylethylene derivatives; and (2) with the fluorescent nanoparticle, a high sensitive sensing to 2,4,6-trinitrophenol can be realized, which means that the fluorescent nanoparticle has a broad application prospects in the sensing technology field of explosive nitro compounds.