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Graphene/hyaluronic acid assembly taking cyclodextrin as medium and preparation method thereof

A technology of hyaluronic acid and graphene, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as graphene instability and safety, and achieve improved stability and biocompatibility, high anticancer activity, and the effect of reducing toxic and side effects

Inactive Publication Date: 2014-07-16
NANKAI UNIV
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Problems solved by technology

However, graphene has always had problems such as instability under physiological conditions and safety in vivo.

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  • Graphene/hyaluronic acid assembly taking cyclodextrin as medium and preparation method thereof
  • Graphene/hyaluronic acid assembly taking cyclodextrin as medium and preparation method thereof
  • Graphene/hyaluronic acid assembly taking cyclodextrin as medium and preparation method thereof

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Embodiment

[0029] A cyclodextrin-mediated graphene / hyaluronic acid supramolecular assembly based on β -Nano-supramolecular assembly synthesized by cyclodextrin-modified graphene and adamantane-modified hyaluronic acid, wherein β - Cyclodextrin modified graphene, its thickness is 2.5 nm, and 1 g of graphene is modified with 0.28 g of β - Cyclodextrin ethylenediamine; adamantane-modified hyaluronic acid has an adamantane unit modified on average for every 7.7 hyaluronic acid units; the supramolecular assembly is passed β -Strong host-guest interactions between cyclodextrin and adamantane combine graphene and hyaluronic acid to form a supramolecular assembly with a thickness of 4.5 nm and an average size of 80 nm.

[0030] A kind of described cyclodextrin is the preparation method of the graphene / hyaluronic acid supramolecular assembly of medium, comprises the following steps:

[0031] (1) Synthesis of N-(2-aminoethyl)-1-adamantanecarboxamide

[0032] 1) Dissolve 5.25 g (0.087 mo...

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Abstract

The invention discloses a graphene / hyaluronic acid assembly taking cyclodextrin as a medium. The graphene / hyaluronic acid assembly is a nano supermolecule assembly synthesized based on beta-cyclodextrin-modified graphene and adamantine-modified hyaluronic acid, wherein graphene is modified by beta-cyclodextrin; by virtue of strong host-guest interaction between beta-cyclodextrin and adamantine, graphene and hyaluronic acid are combined together to form the supermolecule assembly. The graphene / hyaluronic acid assembly has the advantages that the supermolecule assembly greatly improves stability and biocompatibility of the cyclodextrin-modified graphene under physiological conditions; by utilizing targeted recognition action of hyaluronic acid on tumor cells, the supermolecule assembly can selectively kill the cancer cells, and has anti-cancer activity higher than that of pure drug camptothecin; the targeted drug transmission system is simple in preparation process, easy to implement and low in material cost, and has potential application prospect in clinic treatment of cancers.

Description

technical field [0001] The invention relates to the technical field of targeted delivery of anticancer drugs, in particular to a cyclodextrin-mediated graphene / hyaluronic acid nano-supramolecular assembly and a preparation method thereof. Background technique [0002] Drug loading systems based on nanomaterials have important applications in the fields of nanotechnology and biomedicine due to their functions of drug payload, targeted delivery and controlled release. Graphene is a novel nanomaterial with a two-dimensional planar structure developed in recent years. Due to its unique mechanical properties, thermodynamic properties, chemical properties and optical properties, it is used as a drug carrier and biosensor in the field of biomedicine. The application value is gradually reflected. The surface of graphene can load many anticancer drug molecules with large π system through π-π interaction and hydrophobic interaction, such as doxorubicin and camptothecin, which can ef...

Claims

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Application Information

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IPC IPC(8): A61K47/40A61K47/36A61K47/04A61K31/4745C08B37/08A61P35/00
Inventor 刘育曹宇张瀛溟
Owner NANKAI UNIV
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