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Porous semi-degraded hydrogel material used for cartilage repair and preparation method thereof

A porous hydrogel and cartilage repair technology, applied in medical science, prostheses, etc., can solve the problems that the connection between the implant and the surrounding cartilage tissue cannot be improved, and achieve the effect of ensuring the mechanical strength and solving the connection problem

Inactive Publication Date: 2013-11-27
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent (200910117158.6) mentions a preparation method of a layered biomimetic articular cartilage repair and replacement material, so that the bioactive nano-hydroxyapatite is distributed in a gradient along the thickness direction in the PVA hydrogel. The strength of the connection between the implant and the underlying natural articular cartilage, but does not improve the connection between the implant and the surrounding cartilage tissue

Method used

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  • Porous semi-degraded hydrogel material used for cartilage repair and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0025] (1) PLGA microspheres were prepared by emulsification-solvent evaporation method. The method described is to weigh 480mg of PLGA solid particles, put it into 16ml of acetone and dichloromethane mixture solution (1:3 by volume), and ultrasonically dissolve it completely to obtain a uniform PLGA solution. The obtained solution was added dropwise into 10 times the volume of 2wt% low-viscosity PVA solution with a dropper, and the PVA solution was magnetically stirred at a speed of 1000 r / min and placed in an ice-water bath. After the dropwise addition, the solution was sealed, taken out from the ice-water bath, and continued to stir on a magnetic stirrer at a speed of 1000 / min for 10 min. Then, peel off the sealing film, and continue to stir at a speed of 400r / min for 12 hours, so that the acetone and dichloromethane solvents are fully volatilized. Finally, PLGA microspheres were obtained by suction filtration, washing and freeze-drying.

[0026] (2) Weigh PVA and PVP pow...

Embodiment 2

[0031] (1) PLGA microspheres were prepared by emulsification-solvent evaporation method. The method described is to weigh 480mg of PLGA solid particles, put it into 16ml of acetone and dichloromethane mixture solution (1:3 by volume), and ultrasonically dissolve it completely to obtain a uniform PLGA solution. The obtained solution was added dropwise into 10 times the volume of 2wt% low-viscosity PVA solution with a dropper, and the PVA solution was magnetically stirred at a speed of 1000 r / min and placed in an ice-water bath. After the dropwise addition, the solution was sealed, taken out from the ice-water bath, and continued to stir on a magnetic stirrer at a speed of 1000 / min for 10 min. Then, peel off the sealing film, and continue to stir at a speed of 400r / min for 12 hours, so that the acetone and dichloromethane solvents are fully volatilized. Finally, PLGA microspheres were obtained by suction filtration, washing and freeze-drying.

[0032] (2) Weigh PVA and PVP pow...

Embodiment 3

[0037](1) PLGA microspheres were prepared by emulsification-solvent evaporation method. The method described is to weigh 480mg of PLGA solid particles, put it into 16ml of acetone and dichloromethane mixture solution (1:3 by volume), and ultrasonically dissolve it completely to obtain a uniform PLGA solution. The obtained solution was added dropwise into 10 times the volume of 2wt% low-viscosity PVA solution with a dropper, and the PVA solution was magnetically stirred at a speed of 1000 r / min and placed in an ice-water bath. After the dropwise addition, the solution was sealed, taken out from the ice-water bath, and continued to stir on a magnetic stirrer at a speed of 1000 / min for 10 min. Then, peel off the sealing film, and continue to stir at a speed of 400r / min for 12 hours, so that the acetone and dichloromethane solvents are fully volatilized. Finally, PLGA microspheres were obtained by suction filtration, washing and freeze-drying.

[0038] (2) Weigh PVA and PVP powd...

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Abstract

The invention discloses a porous semi-degraded hydrogel material used for cartilage repair and a preparation method thereof, belonging to the technical field of articular cartilage repair. The preparation method is specifically characterized by adding mixed liquor of degradable PLGA (poly(lactic-co-glycolic acid)) microspheres with biological activities and a compound pore-foaming agent to a hydrogel solution and finally obtaining the porous semi-degraded hydrogel material through several times of physical crosslinking of freezing and unfreezing after stirring the solution uniformly at high temperature. The hydrogel material has the obvious advantages that the advantage of biological activities of the PLGA microspheres and the advantage of excellent biomechanical properties of the hydrogel material are combined; the porous structure of the prepared porous hydrogel material containing the PLGA microspheres is suitable for cell seeding and migration; regeneration of cartilage tissues is induced by degradation of the PLGA microspheres, so that the problem of connection between repair materials and surrounding tissues can be effectively solved; and meanwhile, the excellent mechanical properties of the hydrogel material are conductive to ensuring the mechanical strength of implanting initial materials.

Description

technical field [0001] The invention belongs to the technical field of articular cartilage repair, and in particular relates to a porous semi-degradable hydrogel material for cartilage repair and a preparation method thereof. Background technique [0002] Articular cartilage lacks self-repair ability, and if the treatment is not timely or appropriate, it will bring serious dysfunction to patients. The repair of defective cartilage has always been one of the most urgent problems in the medical field. Due to trauma, tumor or joint disease, and the aggravation of aging society, the incidence of cartilage defects is increasing worldwide. [0003] Clinical methods for repairing cartilage defects include autologous cartilage transplantation, allogeneic cartilage transplantation, and artificial joint replacement. These methods have greatly limited their clinical application due to problems such as donor sources, immune rejection, or material failure. In recent years, the de...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/56A61L27/52
Inventor 熊党生石雁曹翼
Owner NANJING UNIV OF SCI & TECH
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