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Tissue repair material in polycomponent amino acid polymers and preparation method thereof

A tissue repair and amino acid technology, applied in medical science, prosthesis, etc., can solve the problems of loss of physiological activity, good softness, poor rigidity, etc., and achieve the effects of meeting medical needs, low cost, and shortened response time.

Inactive Publication Date: 2012-06-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no synthetic polymer material that can achieve the precise structure and complex composition of collagen
However, because collagen has a complex three-dimensional configuration, it has good softness but poor rigidity. It will denature after heating and lose its physiological activity, so it cannot be processed at high temperature.

Method used

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  • Tissue repair material in polycomponent amino acid polymers and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～9

[0017] The amount of caprolactam and other amino acids is shown in Table 1. Add it to a 250ml three-neck bottle, and under the protection of nitrogen, stir and slowly heat up to 80°C-200°C. ~250°C for polymerization. The reaction times are shown in Table 1. After cooling to room temperature, an orange-yellow product was obtained with a yield greater than 95%. The mechanical properties, weight loss rate, degree of polymerization and viscosity of the obtained degradable polymer are also shown in Table 1.

Embodiment 10

[0019] Add 90g of caprolactam, 1g of glycine, 6g of alanine, 7g of phenylalanine, 2g of lysine, and 6g of hydroxyproline into a 250ml three-necked bottle. Under stirring, the temperature was raised slowly to 200°C and melted. Raise the temperature to 220°C for 3 hours, then raise the temperature to 230°C for 3.5 hours, and cool to room temperature to obtain an orange-yellow product with a yield of 96%; the melting point is 175°C, and the resulting degradable polymer has a compressive strength of 90 MPa and a tensile strength of 83Mpa, flexural strength 65Mpa, elastic modulus 2.6Gpa; its degree of polymerization is 310, viscosity at 220°C is 3100Pa·S; after soaking in simulated body fluid for 12w, the weight loss is 32%.

Embodiment 11

[0021]Add 85g of caprolactam, 1g of glycine, 4g of alanine, 6g of phenylalanine, 2g of lysine, 6g of hydroxyproline, and 2g of tyrosine into a 250ml three-necked bottle. In , under the protection of nitrogen, stir and slowly raise the temperature to 200°C and melt. Raise the temperature to 220°C for 3 hours, then raise the temperature to 230°C for 3 hours, and cool to room temperature to obtain an orange-yellow product with a yield of 97%; the melting point is 171°C, and the obtained degradable polymer has a compressive strength of 91Mpa and a tensile strength of 85Mpa, flexural strength 62Mpa, elastic modulus 2.2Gpa; its degree of polymerization is 300, viscosity at 220°C is 3000Pa·S; after soaking in simulated body fluid for 12w, the weight loss is 21%.

[0022] Example 11

[0023] Caprolactam 90g, glycine 1g, alanine 3g, phenylalanine 7g, lysine 2g, hydroxyproline 6g, tyrosine 3g, serine 5g, leucine 1.31g were added to a 250ml three-necked bottle, and Under the protection...

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Abstract

The invention discloses a repair material of a multi-component amino acid polymer for tissues and a preparation method thereof. The repair material is obtained from the polymerization of caprolactam with at least 5 kinds of other amino acids, wherein, the mole ratio of the caprolactam is 40 percent to 90 percent and the remaining parts are other amino acids with a mole ratio larger than or equal to 0.5 percent for a single kind amino acid. Under the protection of inert gases, the varied raw amino acids are heated and melted and then undergo pre-polymerization reaction and polymerization reaction in sequence at 210 DEG C to 220 DEG C and 230 DEG C and 250 DEG C respectively, thus the repair material is prepared. Other amino acids are selected from glycine, alanine, leucine, isoleucine, valine, threonine, serine, phenylalanine, tyrosine, tryptophan, praline, hydroxyproline, lysine and arginine. The material contains no catalyzer or other assistants, has good biological safety and compatibility, as well as good and controllable mechanical property and degradation speed, and can be singly used for repairing and reconstructing human tissues or can be used for repairing and reconstructing human tissues after being formed into a composite material.

Description

technical field [0001] The present invention relates to a tissue repair material in the form of a polymer and a preparation method thereof in the medical field, specifically a tissue repair material in the form of a polymer polymerized by multi-component amino acids and a preparation method thereof. Background technique [0002] Currently used medical polymer bone tissue repair materials can be divided into two types: non-degradable and degradable. Non-degradable polymer materials can include polyethylene, polypropylene, polyacrylate, aromatic ester, polysiloxane, polyoxymethylene, etc., which can remain stable for a long time in the biological environment without degradation, crosslinking, etc. Changes, and has good physical and mechanical properties. Because these polymer materials are biologically inert, they can generally be implanted in the body for a long time and used at stable load-bearing sites, but their functions in hard tissue repair and reconstruction are limit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/58
Inventor 严永刚李鸿吕国玉王云芳杨杰张其翼杨爱萍
Owner SICHUAN UNIV
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