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118results about How to "Good biomechanical properties" patented technology
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Tissue engineered osteochondral implant
ActiveUS7931687B2Increase gravitySmall apertureBiocideBone implantBone implantOsteochondral grafting
Compositions, methods of production and use, and kits for an osteochondral graft involving both articular cartilage and underlying bone are provided.
Owner:RUSH UNIV MEDICAL CENT +1
Porous medical tantalum implant material and preparation method thereof
ActiveCN103480043AHigh porosityHigh connected porosityChemical vapor deposition coatingProsthesisPorosityGraphite carbon
The invention discloses a porous medical tantalum implant material and a preparation method and application thereof. The porous medical tantalum implant material is prepared through the steps of reducing a tantalum metal compound into tantalum metal powder and uniformly depositing the tantalum metal powder on the surface of a graphite carbon skeleton to form a tantalum coating according to the chemical vapor deposition method, wherein the tantalum metal compound is one of tantalum pentachloride and tantalum fluoride; the porosity of the graphite carbon skeleton is greater than 70% and the aperture is 200-600 microns; the tantalum coating is 40-60 microns in thickness. The porous medical tantalum implant material is high in porosity and uniform in pore size, adopts an interconnected porous structure, has few dead pore spaces, is similar to a human cancellous bone, can promote bone ingrowth, and can be applied to repairing injured bones at multiple parts of a body and bone defects after osteonecrosis.
Owner:赵德伟
Medical porous tantalum metal material and preparation method thereof
ActiveCN105177523AHigh porosityUniform porosityBone implantTissue regenerationPorous tantalumGas phase
The invention discloses a medical porous tantalum metal material and a preparation method thereof. The medical porous tantalum metal material is prepared through the steps that through a chemical vapor deposition method, tantalum metal compounds are reduced to tantalum metal powder, the tantalum metal powder is evenly deposited on the surface of a porous silicon support to form a tantalum coating, and then the medical porous tantalum metal material is prepared, wherein one of tantalum pentachloride and fluoride tantalum is adopted as the tantalum metal compounds, the porosity of the porous silicon support is larger than 70 percent, the pore diameter of the porous silicon support is 100-600 micrometers, and the thickness of the tantalum coating is 10-50 micrometers. According to the medical porous tantalum metal material and the preparation method thereof, the porous tantalum metal material is of a communicated porous structure, is high in porosity, uniform in pore, few in pore dead space and similar to the cancellous bones of a human body and can promote bone ingrowth and be applied to bone defect repair after bone trauma and osteonecrosis of multiple portions in the human body occur.
Owner:伟坦(大连)生物材料有限公司
Antibacterial medical metal material capable of being degraded in body fluid, and applications thereof
InactiveCN104513922AGood biocompatibilitySatisfactory degradabilityProsthesisBiomechanicsMetallic materials
The present invention provides a magnesium-copper alloy, which contains magnesium and copper, wherein the copper content is less than or equal to 3 wt%, and the balance is the magnesium. According to the present invention, the magnesium-copper alloy has characteristics of good biodegradability, satisfactory degradability, high biological safety, and excellent biomechanical property, has application values in medical fields of endosseous implants and the like, especially continuously and slowly releases metal ions with the bacterial inhibiting effect to the surrounding tissue through in vivo degradation, has effects of effective prevention and treatment of infections surrounding implants, and has a certain angiogenesis activity.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Composite material of organic/inorganic multi-phase induction nano-hydroxyapatite
InactiveCN106075590AGood biocompatibilityAchieve nanoscale dispersionTissue regenerationProsthesisPhosphateApatite
The invention discloses a composite material of organic / inorganic multi-phase induction nano-hydroxyapatite. The composite material is characterized in that on the basis of the effect that graphene oxide can enhance adhesion of stem cells, and stem cells are induced to be differentiated into bone cells and adsorb organic and inorganic nanoparticles, chitosan and bovine collagen are adopted as organic matrixes, a graphene oxide water solution is adopted as an inorganic matrix, a soluble calcium salt and a soluble phosphate are adopted as a precursor of inorganic phase nano-hydroxyapatite, a biological mechanism and an in-situ composite preparation technology are adopted, and the composite material of organic / inorganic multi-phase induction nano-hydroxyapatite is prepared bionically. The preparation conditions are mild, the composite material is uniform in pore diameter, the hole forming performance is good, the biocompatibility and biodegradability are good, and the composite material is expected to be the novel composite material for treating osteoporosis.
Owner:FUZHOU UNIV
Degradable magnesium alloy implanting material for bone fixation and preparing method of degradable magnesium alloy implanting material
ActiveCN105349858AImprove and enhance mechanical propertiesImproved and enhanced biocompatibilityMg alloysBiomechanics
The invention relates to a degradable magnesium alloy implanting material for bone fixation and a preparing method of the degradable magnesium alloy implanting material. The implanting material is prepared from, by mass percent, 0.5-4% of Mg, 0.5-4% of Ag and the balance Y. The preparing method of the implanting material comprises the steps of ingot casting metallurgy, extruding, rolling and heat treatment. The prepared implanting material meets the requirement of plates, rods and profiles, wherein the plates, the rods and the profiles serve in biological fluid environments. By means of alloy materials, the good comprehensive mechanical performance needed by bone fixing materials is ensured, the beneficial effects of being capable of inhibiting bacteria, resistant to corrosion, free of cytotoxicity, good in biological mechanical property and the like are achieved, and the alloy materials can be degraded under the biological fluid environments. The implanting material can serve as bone nails or marrow nails or bone fraction plates or other various devices to be used under the medical conditions, and the comprehensive performance is good; and especially, the implanting material has both the biomechanical property and the biodegradable performance at the same time, and the typical defect of existing metal materials of a titanium alloy or stainless steel or high polymer materials in application of the department of orthopaedics is overcome.
Owner:CENT SOUTH UNIV
Cervical vertebra uncovertebral joint fusion cage
The invention discloses a cervical vertebra uncovertebral joint fusion cage which comprises uncovertebral joint fusion components and a vertebrae inter elastic supporting body. The cross section of the vertebrae inter elastic supporting body is trapezoidal, and the front end of the vertebrae inter elastic supporting body is a small end. The two uncovertebral joint fusion components are connected to two waist outer side surfaces of the vertebrae inter elastic supporting body respectively and are of a cylindrical mesh structure, and baffles are connected to the side faces, away from the vertebrae inter elastic supporting body, of the uncovertebral joint fusion components. The cervical vertebra uncovertebral joint fusion cage can reduce cost, the fusion time is short, the wearing time of a neck collar is shortened, the comfort level of a patient is improved, an end plate does not need to be ground, the surgical time is shortened, and the sinking risk of prostheses after an operation is reduced.
Owner:山东康盛医疗器械股份有限公司
Reductively biodegradable type honeycomb polyurethane support, and preparation method and application thereof
InactiveCN103495203AEffectively regulates degradabilityStrong controllability of biodegradationProsthesisPolyesterStructural formula
The invention discloses a reductively biodegradable type honeycomb polyurethane support, and a preparation method and application thereof. The preparation method comprises: taking 2,2'-dithiodiethanol as an initiator, employing a ring-opening polymerization method to synthesize double-hydroxy-terminated polycaprolactone containing disulfide bonds; reacting with diisocyanate containing a disulfide bond to form polyester type polyurethane containing disulfide bonds; then dipping a biological template wisteria sinensis with a sodium chloride solution and calcining to obtain a negative template porous sodium chloride of wisteria sinensis; and finally immersing the negative template porous sodium chloride of wisteria sinensis with a waterless organic solution of the polyester type polyurethane containing disulfide bonds, drying and removing the negative template to obtain the honeycomb polyurethane support, wherein the molecular structural formula of the polyurethane is shown in the description. The reductively biodegradable type honeycomb polyurethane support has the advantages of simple technology, easy batch preparation, and strong biodegradation controllability; and the honeycomb structure is beneficial to transportation of substances inside or outside the support, the support can be used as a porous support for tissue regeneration repair, and belongs to a tissue engineering support material with excellent comprehensive performances.
Owner:XI AN JIAOTONG UNIV
Tissue repair material in polycomponent amino acid polymers and preparation method thereof
InactiveCN101385869AGood biocompatibilityImprove biological activityProsthesisTissue repairHydroxyproline
The invention discloses a repair material of a multi-component amino acid polymer for tissues and a preparation method thereof. The repair material is obtained from the polymerization of caprolactam with at least 5 kinds of other amino acids, wherein, the mole ratio of the caprolactam is 40 percent to 90 percent and the remaining parts are other amino acids with a mole ratio larger than or equal to 0.5 percent for a single kind amino acid. Under the protection of inert gases, the varied raw amino acids are heated and melted and then undergo pre-polymerization reaction and polymerization reaction in sequence at 210 DEG C to 220 DEG C and 230 DEG C and 250 DEG C respectively, thus the repair material is prepared. Other amino acids are selected from glycine, alanine, leucine, isoleucine, valine, threonine, serine, phenylalanine, tyrosine, tryptophan, praline, hydroxyproline, lysine and arginine. The material contains no catalyzer or other assistants, has good biological safety and compatibility, as well as good and controllable mechanical property and degradation speed, and can be singly used for repairing and reconstructing human tissues or can be used for repairing and reconstructing human tissues after being formed into a composite material.
Owner:SICHUAN UNIV
Nanometer artificial bone scaffold with structure similar to that of natural bone and preparation method thereof
ActiveCN104441668AAddress cell proliferationSolve the mechanical propertiesBone implantSelective laser sinteringBiomechanics
The invention relates to the technical field of medical artificial bone transplantation materials. At present, bone transplantation is widely distributed in multiple fields such as orthomorphia, oral cavity, craniofacial region and the like. But all preparation methods of artificial bone transplantation materials have the problems that the manufacture period is long, the yield is low, and prepared artificial bone transplantation materials do not have precise anatomical morphology same to that of natural bone, and the like. The invention aims at providing a nanometer artificial bone scaffold possessing good bioactivity and excellent mechanical properties and a structure similar to that of natural bone. A selective laser sintering technology is employed, poly-epsilon-caprolactone and hydroxylapatite are taken as raw materials, and layer-by-layer sintering is performed according to a designed model and set parameters, and finally the artificial bone scaffold with the structure similar to that of natural bone is obtained. The artificial bone scaffold has outstanding biocompatibility, cells have relatively high propagation rate on the artificial bone scaffold, and the scaffold keeps good biomechanical properties.
Owner:德普斯医疗器械湖州有限公司
3D-printed porous tantalum metal bone plate
ActiveCN109793565AAids in healingAvoid stress shieldingAdditive manufacturing apparatusBone platesOsseointegrationBone growth
The invention relates to a 3D-printed porous tantalum metal bone plate. The 3D-printed porous tantalum metal bone plate is characterized in that tantalum metal powder is taken as a base material, andthe bone-imitating trabecular bone plate having bone induction property and produced by 3D printing has an interconnecting-pore structure fit for bone growth. The production method includes: under argon production, using medical grade spherical tantalum powder as a raw material to produce the porous bone plate by 3D printing; removing excess metal powder adhering to the surface of the bone plate through sandblasting; removing residual stress through heat treatment to make the surface of the bone plate smooth. By the arrangement, the porous bone plate with the bone induction property can form excellent bone integration with bone tissue so as to achieve permanent fixation in biology.
Owner:赵德伟 +2
Polymethyl methacrylate bone cement and preparation method thereof
ActiveCN108096629AWon't hurtModerate viscosityTissue regenerationProsthesisSolid componentOsseointegration
The invention relates to a polymethyl methacrylate bone cement and a preparation method thereof. Concretely, the bone cement comprises a solid component and a liquid component. The solid component comprises a solid component A including polymethyl methacrylate, a methyl methacrylate-styrene segmented copolymer, a contrast agent, and an initiator; and a solid component B including mineralized collagen. The liquid component includes methyl methacrylate, a stabilizer and an accelerating agent. Through control of the molecular weight and ratio of the components, it is ensured that the obtained PMMA bone cement doesn't release a large amount of heat during application, thereby preventing damage to the surrounding bone tissue. The bone cement is suitable in viscosity and has random plasticity. Through addition of mineralized collagen which is excellent in osteogenic activity, the mechanical property and biocompatibility of bone cement are improved, and the bone cement is excellent in osseointegration capability and low in elastic modulus.
Owner:BEIJING ALLGENS MEDICAL SCI & TECH
New application of HuGu capsule in preventing glucocorticoid-induced osteoporosis
ActiveCN101890127ANo change in biomechanical propertiesGood effectSkeletal disorderUnknown materialsExperimental proofMedicine
The invention relates to a new application of a HuGu capsule (HG) in preventing glucocorticoid-induced osteoporosis (GIO), belonging to the technical field of traditional Chinese medicine application. The invention discusses HG prevention effect towards GIO induced by glucocorticoids (GCs) based on bone histomorphometry. The experimental result proves that the glucocorticoids (GCs) can induce cortical bone loss of a rat in short time, after HG intervention is carried out for 45d, the GCs is prevented from inducing the cortical bone loss of the rat, thereby providing experimental proof for the new application of the HG in preventing the GIO.
Owner:GUANGDONG ANNOL PHARM CO LTD
Tissue engineering stent based on low-temperature rapid modeling and preparation method thereof
ActiveCN106668948AOvercome sizeOvercome the defects that are too small (<100μm)Tissue regenerationCoatingsBiomechanicsMass ratio
The invention relates to a tissue engineering stent based on low-temperature rapid modeling and a preparation method thereof. The preparation method comprises the following steps: mixing a polylactic acid-glycolic acid copolymer and an organic solvent in a mass ratio of 1: 6 to 1: 8 to prepare a PLGA (polylactic acid-glycolic acid) solution, and adding sodium chloride granules to obtain a printing slurry, wherein the mass ratio of the sodium chloride granules to the PLGA is 1: 2 to 2: 1; setting the fiber diameter to be 200-300 microns, setting the fiber spacing to be 300-350 microns, printing out a stent body containing the sodium chloride granules at a speed of 3-6mm / s, and removing the organic solvent and the sodium chloride to obtain the tissue engineering stent based on the low-temperature rapid modeling. According to the invention, through addition of an excipient, low-temperature printing of a PLGA material is achieved, and the defect of a too large or too small aperture size caused by high-temperature fused printing of a PLGA stent is overcome; the prepared PLGA stent is moderate in aperture size, can easily store cells, and has good biomechanical properties.
Owner:杭州弘新生物科技有限公司
Composition for improving osteoporosis and increasing bone mineral density, preparation method of same and application of the same in preparation of health-caring product
InactiveCN104206949ANo wearFree from destructionOrganic active ingredientsPeptide/protein ingredientsBone densityBULK ACTIVE INGREDIENT
A composition for improving osteoporosis and increasing bone mineral density, a preparation method of the same and an application of the same in preparation of a health-caring product. The composition comprises an active ingredient and auxiliary materials and is characterized in that the active ingredient includes following components, by weight, 65-85 parts of a raw medicine in an extract of epimedium, 5-15 parts of glucosamine, 5-15 parts of chondroitin sulfate, 1.5-3.5 parts of collagen and a proper amount of vitamin D3; and the auxiliary materials include following components, by weight, 1.5-4.5 parts of an excipient and 0.2-1.5 parts of a lubricant. The composition is designed especially for middle-aged and elderly people and is strong in targeted performance. In the invention, the composition is prepared through integration of Chinese and western medicines, not only is traditional Chinese medicine guide theory inherited but also modern medicinal treatment methods are referenced. An experimental result proves that epimedium in the formula can increases the bone mineral density and the chondroitin sulfate, the glucosamine, the collagen and the vitamin D3 have an effect of improving the osteoporosis. The composition has excellent effects of increasing the bone mineral density and promoting absorption of calcium.
Owner:JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD
Nanometer artificial bone framework with transverse gradient hole structure and preparation method thereof
InactiveCN102429745AGood biomechanical strengthGood biomechanical propertiesBone implantNatural boneBiomechanics
The invention relates to the technical field of the medical artificial bone grafting material. At present, no documents available report a nanometer artificial bone framework with a transverse gradient hole structure which is the same as a natural bone. The invention aims to provide a nanometer artificial bone framework which has good bioactivity, excellent mechanical property and the transverse gradient hole structure which is the same as a natural bone. The preparation method comprises the steps of: dissolving hydroxyapatite (HA) in a salt (NaCl) solvent to prepare a HA sol; then dissolving polycaprolactone (PCL) slowly in the HA sol; then heating and removing the solvent at a higher temperature; and finally casting layer by layer to a special mould to prepare a HA / PCL composite material. In the invention, the artificial bone framework which is similar to the structure of the natural bone and has the transverse gradient hole structure is obtained and the cells on the prepared artificial bone framework have higher reproduction rate and the framework has good biomechanical properties.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Bone cement stirrer
ActiveCN102009438AGood biomechanical propertiesEasy to fillCement mixing apparatusOsteosynthesis devicesBone cementBiomedical engineering
The invention relates to a bone cement stirrer comprising a control cabinet, a stirring shaft as well as an injector sleeve and a stirring device. The control cabinet is internally provided with a motor, the stirring shaft is fixedly connected with a rotating shaft of the motor, the injector sleeve is provided with a Ruhr joint at the front end and a top end opening blind nut at the rear end, thestirring device is arranged in the injector sleeve, the rear end of the stirring device is dismountably connected with the end part of the stirring shaft, and the injector sleeve is connected with a vacuumizing device through the Ruhr joint at the front end. The bone cement stirrer of the invention finishes stirring bone cement under vacuum condition, enables the bone cement to reach favorable properties through uniform stirring and ensures that the stirred bone cement has favorable biomechanical performance so as to achieve more ideal filling effect.
Owner:SHANGHAI KINDLY MEDICAL INSTR CO LTD
Preparation method for artificial cartilage
ActiveCN106552286ASolve the problem of low porosity,Solve the defect of less connected holesProsthesisPorosityBiocompatibility Testing
The invention provides a preparation method for artificial cartilage. According to the method, a non water-soluble organic macromolecule material is prepared into a three-dimensional network-shaped porous support through 3D printing; meanwhile, a PVA solution is mechanically mixed with nano-hydroxyapatite powder, and an HA-PVA composite solution is obtained; then the HA-PVA composite solution is used for performing mold reversing on the three-dimensional network-shaped porous support, after the HA-PVA composite solution is made to permeate into the three-dimensional network-shaped porous support, the HA-PVA composite solution permeating into the three-dimensional network-shaped porous support is placed into an artificial cartilage mold, and an artificial cartilage / porous support composite body is obtained through a repeated freezing and thawing method; and the porous support of the obtained the artificial cartilage / porous support composite body is selectively dissolved through a solvent, and the artificial cartilage is obtained. The prepared artificial cartilage is good in biocompatibility, the biomechanical performance is close to that of cartilage, the porosity rate is high, regular through large holes and a small communicating hole system are achieved, and bone cells can grow to enters the cartilage and are perfectly combined with the artificial cartilage.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV
Multiphase hybrid micro-nano structure magnetic composite material and preparation method thereof
InactiveCN106075589AImprove adhesionPromote growthTissue regenerationProsthesisPhosphateBiocompatibility Testing
The invention discloses a multiphase hybrid micro-nano structure magnetic composite material. By serving chitosan and bovine collagen as organic matrixes, dissolvable calcium salt and dissolvable phosphate as precursors of inorganic phase nano-hydroxyapatite and serving dissolvable molysite and dissolvable ferrite as precursors of inorganic phase paramagnetic nano ferroferric oxide, the multiphase hybrid micro-nano structure magnetic composite material is prepared through a biological mechanism and an in-situ synthesis preparation technology. Preparation conditions are mild, and the obtained composite material is uniform in pore diameter and good in pore-forming performance, biocompatibility and biodegradability and is expected to become a novel composite material for repairing bone tumors.
Owner:FUZHOU UNIV
Dual-phase magnetic nano-composite scaffold material and preparation method thereof
InactiveCN107875443APromote cell adhesionLow toxicityTissue regenerationProsthesisChemistryBiocompatibility Testing
The invention discloses a dual-phase magnetic nano-composite scaffold material. The dual-phase magnetic nano-composite scaffold material is prepared by compositing a cartilago phase with a bone phase,wherein the cartilago phase contains polylactic acid and a natural polymer compound; and the bone phase contains polylactic acid, nano-hydroxyapatite and magnetic nanoparticles. The invention furtherdiscloses a preparation method of the dual-phase magnetic nano-composite scaffold material. The three-dimensional dual-phase magnetic nano-composite scaffold material is prepared from polylactic acid, the natural polymer compound, nano-hydroxyapatite and the magnetic nano particles by virtue of a low-temperature rapid forming technique and is integrated with the advantages of the four materials,is capable of promoting the adhesion and proliferation of cells, reducing the toxicity of degradation products and improving the biomechanical properties based on good osteoconduction and biocompatibility and is relatively beneficial to the adhesion growth and vascularization of solid cells, and the speed and effect of the coalescence between artificial cartilages transplanted at bone defect partsof a joint cartilage and a subchondral bone and the bones are greatly increased and improved.
Owner:THE SECOND PEOPLES HOSPITAL OF SHENZHEN
PLGA three-dimensional nerve conduit and preparation method thereof
ActiveCN106075578AImprove adhesionPromotes axon growthPharmaceutical delivery mechanismElectro-spinningYarnTissue repair
The invention relates to a PLGA three-dimensional nerve conduit and a preparation method thereof. The PLGA three-dimensional nerve conduit comprises a laminin coating and an orientation yarn core layer. The preparation method comprises the steps that a polylactide acid-glycolic acid copolymer (PLGA) is dissolved into a solvent, and the materials are mixed to be uniform to obtain a spinning solution; single-spray-head electrostatic spinning is conducted to obtain the PLGA three-dimensional nerve conduit containing the orientation yarn core layer, the PLGA three-dimensional nerve conduit is bonded with laminin through covalent bonds, and then the PLGA three-dimensional nerve conduit which is provided with the laminin coating and contains the orientation yarn core layer is obtained. The three-dimensional nerve conduit which is provided with the laminin coating and filled with orientation yarn has the good mechanical property, biological activity and degradation property; protein in the coating can promote nerve cell adhesion and nerve axon regeneration, and meanwhile, the yarn in the core layer can induce nerve cells to grow in a crawling mode in the yarn orientation direction, so that regeneration and reconstruction of three-dimensional nerve tissue are promoted, and important application can be achieved in peripheral nerve tissue repair and regeneration.
Owner:DONGHUA UNIV
Novel bone tissue engineering scaffold and preparation method thereof
The invention relates to the technical field of biomedical tissue engineering, in particular to a novel bone tissue engineering scaffold and a preparation method thereof. The bone scaffold comprises abone material and an exosome-loaded fibrin gel compound, the bone material is provided with holes, and the gel compound is distributed in the holes. The invention researches a bone material which ishighly similar to a natural bone matrix and has osteogenesis and vascularization activities. The porous decellularized tissue engineering scaffold is closer to a normal bone, has good biomechanical properties, is suitable for bone defect repair of a load bearing area, and maximally retains inherent components of the scaffold. According to the method, cell components with most antigens in tissues can be effectively removed, the immunological rejection reaction of grafts is reduced, the approximate morphological structure of the tissues can be maintained, and most tissue matrix components and bioactive factors are retained.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV
Composite bioactivity functional coating
ActiveCN103041449AHigh modulus of elasticityGood biomechanical propertiesCoatingsMetal coatingPhosphate
The invention discloses a composite bioactivity functional coating, in particular a composite bioactivity functional coating positioned on a metal base body. The composite bioactivity functional coating comprises a first titanium metal coating positioned on the metal base body, a tantalum metal coating positioned on the first titanium metal coating and a hydroxyapatite or beta-TCP (tricalcium phosphate) bioactivity coating positioned on the tantalum metal coating.
Owner:苏州宸泰医疗器械有限公司
Tissue- engineered cartilage graftimplant and preparation method thereof
InactiveCN103495208AImprove adhesionPromote vascularizationSkeletal/connective tissue cellsProsthesisCartilage cellsBiomechanics
The invention relates to a tissue tissue-engineered cartilage graftimplant and a preparation method thereof and belongs to the technical field of induced differentiation carried out on bone marrow mesenchymal stem cells (BMSCs) by utilizing a bioactive inducing factor to form a cartilage cell chondroblast composite scaffold material and so as to construct a tissue tissue-engineered cartilage by utilizing a biological activity inducing factor in biomedicine tissue engineering. The tissue tissue-engineered cartilage graftimplant is prepared by adopting the method comprising the following steps: (1) preparing a Nano-HA / PLLA (hyaluronic aciddroxyapatite / poly left L-lactic acid) cartilage scaffold material; (2) carrying out coculture on BMSCs and the Nano-HA / PLLA cartilage scaffold material, and carrying out induced differentiation on BMSCs to form cartilage cells by adopting a cartilage formation inducing solution, so that the tissue tissue-engineered cartilage graftimplant is obtained. The tissue tissue-engineered cartilage graftimplant improves flexibility and biodegradability of the cartilage scaffold material, improves biomechanical property and is more beneficial to adhesion, growth and vascularization of bone cells; an animal experiment proves that the tissue tissue-engineered cartilage graftimplant has a good cartilage defect repairing function.
Owner:THE SECOND PEOPLES HOSPITAL OF SHENZHEN
Flexible extendable stent and methods of surface modification therefor
InactiveUS20100204780A1Good biomechanical propertiesFine surfaceStentsPharmaceutical containersBiomechanicsEngineering
Stent strut and surface geometries are provided for enhancing surface coating applications while providing highly beneficial biomechanical properties. A low-profile, flexible, expandable, elongated, stent assembly is provided and defined by a structure of connected circumferential arrays of webs or bends, the webs or bends and their connections having limited degrees of curvature that help avoid interference during various surface-modifying and surface-enhancing processes.
Owner:CORNOVA
Anti-calcification treatment method of biological material
ActiveCN109589452AImprove anti-calcification propertiesReduce calcificationTissue regenerationProsthesisCalcificationTannin
The invention provides an anti-calcification treatment method of a biological material, which comprises the following steps: removing fat from the biological material, performing decellularization treatment on the biological material, tanning the biological material with a glutaraldehyde tanning solution, soaking the biological material in a tannin solution, soaking the biological material in a 2,3-butanediol solution, and soaking the biological material in a glutaraldehyde preservation solution for preservation. The anti-calcification treatment method of the biological material can obtain a better anti-calcification effect.
Owner:HANGZHOU JIAHEZHONGBANG BIOTECHNOLOGY CO LTD
Tissue renovation material of polymer form and preparation method thereof
ActiveCN101342383BImprove hydrophilicityNo allergiesProsthesisTissue repairEpsilon-Aminocaproic Acid
The present invention relates to a tissue-repairing material in the form of a polymer and a preparation method thereof. Epsilon-aminocaproic acid is polymerized with at least two other types of amine acids to form the tissue-repairing material shown in the formula, wherein, the mole ratio of the Epsilon-aminocaproic acid is 50 percent to 90 percent, and the rest is the other amine acids includingaminoacetic acid, lactamic acid, phenylalanine, lysine and proline. After being sufficiently and uniformly dispersed into water, the materials, amine acids, are heated to less than or equal to 200 DEG C, so that various forms of water can be removed from the materials; the materials are then pre-polymerized under the temperature between 200 DEG C and 220 DEG C and polymerized under the temperature between 220 DEG C and 250 DEG C; and the preparation process is conducted and fulfilled under the protection of an inert gas. The tissue-repairing material has ideal mechanical property, biological activity and controllable degradation property, and the degradation product of the tissue-repairing material is non-toxic and non-irritant. The tissue-repairing material can be widely used for the reparation and reconstruction of the tissues of the human body.
Owner:SICHUAN GUONA TECH
Porous decellularized tissue engineering cartilage support and preparation method thereof
The invention discloses a porous decellularized tissue engineering cartilage support, which is prepared through a decellularized method after tissue engineering cartilage materials are subjected to punching treatment, so as to achieve three-dimensional porosity, higher biomechanical property and biocompatibility. The tissue engineering cartilage support is applicable to defect repair of cartilages in loaded parts, and can become a major breakthrough in defect repair of cartilages in tissue engineering.
Owner:GENERAL HOSPITAL OF PLA
Multilayer bionic joint based on curved surface 3D printing and preparation method thereof
PendingCN112076009ATo achieve the effect of integrationAids in healingJoint implantsTomographyPorous tantalumBones joints
The invention discloses a bionic bone joint based on curved surface 3D printing and a preparation method thereof. The multilayer bionic joint is formed by an inner layer, a middle layer and an outer layer which are in close contact in sequence, wherein the inner layer is a porous tantalum metal support, the middle layer is a solid biological ceramic support, the outer layer is a solid gelatin / sodium alginate composite hydrogel support, the inner layer, the middle layer and the outer layer are all of an arc-shaped shell structure, the radian of the arc-shaped shell is 120-240 degrees, and a cell loading cavity formed by continuous or discontinuous edges formed by protruding outwards from the surface of the outer layer and grooves formed between the edges is formed in the surface of the outer layer. The multilayer bionic joint is large in arc surface radian and suitable for repairing large-area osteochondral joint defects, and the repairing area can be larger than 1 / 2 of the area of thewhole joint. Cells are inoculated into the cell loading cavity, so that the adhesion rate of the cells is increased, and the problem that the surface of the outer layer of the bionic joint is smooth,so that the inoculated cells are not prone to adhesion is solved.
Owner:AFFILIATED ZHONGSHAN HOSPITAL OF DALIAN UNIV +1
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