The invention discloses a model base for craniofacial reconstruction and a craniofacial reconstruction method. The model base for craniofacial reconstruction comprises a craniofacial standard model base and a craniofacial PLSR shape relation model base, wherein physiological points are defined on the craniofacial standard model base. According to the craniofacial reconstruction method, a craniofacial three-dimensional surface model base, on which physiological point corresponding relations are defined, is established through a skin layer point correspondence method and a skull point correspondence method, wherein the skin layer point correspondence method combines partition deformation and multiple restrictions, and the skull point correspondence method is base on TPS overall deformation and multiple restrictions. A craniofacial partial shape relation model based on PLSR is established on the basis of the craniofacial three-dimensional surface model base, and thus the craniofacial PLSR shape relation model base is obtained. By means of a craniofacial standard model, which has the same forensic anthropological information with a to-be-reconstructed skull, in the craniofacial reconstruction model base and the craniofacial PLSR shape relation model, the face of the skull is reconstructed. The craniofacial reconstruction model base is established in the craniofacial partial shape relation modeling method based on PLSR, and the problems that samples are small and variables have multiple correlations in the craniofacial reconstruction method based on statistical theory are solved.