30 results about "Epsilon-Aminocaproic Acid" patented technology

The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N / cm, density of 1-10 mg / cm<3>, chamber diameter of more than 0.75 mm and less than 4 mm and / or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin.The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and / or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, epsilon-aminocaproic acid or alpha2-antiplasmin,

The present invention relates to a solid composition useful for tissue gluing, tissue sealing and hemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N / cm, density of 1-10 mg / cm3, chamber diameter of more than 0.75 mm and less than 4 mm and / or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin.The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibers. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and / or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, ε-aminocaproic acid or α2-antiplasmin,

A hemostatic textile material to stop bleeding comprising a dialdehyde cellulose (DAC) carrier wherein the degree of oxidation of the dialdehyde cellulose varies from about 1.5% to 12%; and a blood coagulation factor selected from the group consisting of chitosan and gelatin; the blood coagulation factor being chemically immobilized thereon; and further optionally comprising a bacteriolytic agent selected from the group consisting of a lysozyme enzyme, silver nitrate, and chlorhexidine; and further optionally comprising a selected component that prevents hemolysis, the component selected from the group consisting of tranexamic acid or ε-aminocaproic acid chemically immobilized thereon.

The invention discloses an amino acid copolymer-calcium sulfate composite material and a preparation method thereof. The composite material mainly comprises a polyamino acid copolymer and calcium sulfate, wherein the polyamino acid copolymer at least contains epsilon- aminocaproic acid, and other amino acids are selected from glycin, lactamine, leucine, isoleucine, valine, threonine, serine, phenylalanine, tyrosine, tryptophan, praline, hydroxyproline, lysine and arginine. The calcium sulfate and amino acid monomers are fully stirred and mixed under the protection of inert gas at a temperatureof between 150 and 160 DEG C, the mixture is removed with moisture, then the mixture is subjected to in-situ polymerization complex reaction at a temperature of between 200 and 250 DEG C, and thus the composite material can be obtained. The degradation proportion of the composite material after the composite material is soaked in a simulated body fluid for 12w can be between 10 and 100 percent, the pH value of a soaking solution is more than 6, and the controllability and adjustability of the degradation rate of the composite material can be realized by a plurality of modes so as to greatly overcome the disadvantages of overquick degradation and the formation of an acid environment when the calcium sulfate is independently taken as a bone repair material.

A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.

A blood cell separation membrane capable of separating blood cells from serum and plasma while preventing blood cell hemolysis. Such a blood cell separation membrane can be obtained by impregnating a porous membrane capable of separating cells from fed blood with a solution containing a hydrophobic aminocarboxylic acid, a protein derived from silk, Tris, TES, [epsilon]-aminohexanoic acid, tranexamic acid or heparin and drying the impregnated membrane.

The invention relates to the application of a class of long carbon chain diamine products in the preparation of copolyamide hot-melt adhesives, in particular the application of decane diamine products in the preparation of copolyamide hot-melt adhesives. Its main technical solutions are: ① Decanediamine does not need to be salt-formed, and can be directly fed to participate in copolymerization to obtain hot-melt adhesives; ② Copolymerized hot-melt adhesives can be composed of ternary components or multiple components; ③ Copolymerized hot-melt adhesives generally contain a , b Two basic units: a. Two or more C6-13 diamines and two or more C6-13 dibasic acids (amine, acid equimolar ratio); b. Caprolactam or ε-aminocaproic acid ; The two units of a and b are composed of: raw material a.60-80%; raw material b.20-40%. Decanediamine belongs to a raw material. Adopting the preparation method of the invention can simplify the technological process, reduce the production cost, and make the operation convenient. The copolyamide hot-melt adhesive produced is widely used in industries such as garment adhesive interlining, shoemaking, automobile industry, packaging and printing.

The present invention provides a blood cell separation membrane for separating blood into serum or plasma and blood cells while preventing hemolysis of the blood cells. Such a blood cell separation membrane can be obtained by impregnating a porous membrane for separating blood cells from blood supplied thereto with a solution containing a hydrophobic aminocarboxylic acid, a protein derived from silk, Tris, TES, ε-aminohexanoic acid, tranexanmic acid, or heparin and then drying the membrane.

The present invention discloses a method for determining content of taurine, epsilon aminocaproic acid and L-aspartic acid in medicine at the same time, which comprises steps of: preparing sample solution to be measured; adding sample solution to be measured, naphthalenedicarboxaldehyde solution and potassium cyanide solution to process derivative reaction with borate buffer solution as reaction medium; entering capillary electrophoretic system to separate and detect, obtaining electrophoretogram of sample solution to be measured; comparing to electrophoretogram of mixture standard solution of taurine, epsilon aminocaproic acid and L-aspartic acid, confirming content of taurine, epsilon aminocaproic acid and L-aspartic acid in sample solution to be measured. The present invention can determine content of taurine, epsilon aminocaproic acid and L-aspartic acid in medicine expediently and rapidly, and has merits of simple operation, short analysis time, a little wastage of reagent and provides an optional method for general analysis and quality control of medicine.

The wound dressing for first aid is one support matter made of biocompatible synthetic material and sprayed with additive containing calcium ion, animal thrombase, aminocaproic acid, antibiotic resisting secondary infection, analgetic, and fibrous primordial cell growth factor or epithelial cell growth factor. The present invention controls hemorrhage through activating body's blood coagulation mechanism and inhibiting fibrin dissolution, and can inhibit massive haemorrhage of both artery and vein effectively in short time. The present invention has no any foreign human protein and thus has no hematogenic virus contamination and excellent safety.