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Composite polymer bone-renovation material containing ceramic component and preparation method thereof

A technology of repairing materials and polymers, applied in medical science, prostheses, etc., can solve the problems of uncontrollable degradation rate of polylactic acid, insufficient mechanical properties of collagen, and limited use of materials to achieve excellent biomechanical properties and biological activity. Compatibility, good biological activity and compatibility, good hydrophilic effect

Inactive Publication Date: 2009-01-14
SICHUAN GUONA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, polylactic acid and collagen are degradable, but as a polymer phase, the degradation rate of polylactic acid is not easy to control, the mechanical properties of collagen are insufficient, and the use temperature is low, which limits the use of materials
The composite materials formed by non-degradable polymers such as nylon 66, polycarbonate, etc. and calcium-phosphorus ceramics are non-degradable. After being implanted in the body, they exist stably for a long time, which limits the regeneration of their own tissues.

Method used

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  • Composite polymer bone-renovation material containing ceramic component and preparation method thereof
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  • Composite polymer bone-renovation material containing ceramic component and preparation method thereof

Examples

Experimental program
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Effect test

example 1～8

[0025] The raw materials and dosages of phosphate, ε-aminocaproic acid, glycine, alanine, phenylalanine, lysine, proline and the like in each example are shown in Table 1 respectively. Put the raw materials into a 250ml three-necked bottle, add 100ml of water, and dehydrate at 200°C (you can judge whether the dehydration process has been completed by observing whether the amino acid starts to melt, etc.). After the dehydration is completed, the temperature is raised to 220°C for pre-polymerization in a molten state, and then the temperature is raised to 230°C to continue the polymerization reaction to obtain a degradable composite material. The time of the two steps of pre-polymerization and polymerization reaction, the yield of polymerization reaction and the corresponding mechanical performance indicators, and the weight loss rate of the obtained composite material after soaking in simulated body fluid for 12w are shown in Table 1, respectively.

example 9

[0027] Add 25g of HA, 105g of ε-aminocaproic acid, and 14g, 3g, and 5g of phenylalanine, glycine, and proline respectively into a 250ml three-neck flask, add 100ml of water, and dehydrate at 200°C. The dehydration is complete Afterwards, the temperature was raised to 220° C., and the melting reaction was carried out for 3 hours, and the temperature was further raised to 230° C. for 3 hours to obtain a degradable composite material with a yield of 96%. The obtained composite material has a viscosity of 3100Pa·S (240°C), a compressive strength of 106Mpa, a tensile strength of 96Mpa, a bending strength of 71Mpa, and an elastic modulus of 2.6Gpa; after soaking in simulated body fluid for 12w, the weight loss is 11.4%.

example 10

[0029] Add 25g of ADCP, 96g of ε-aminocaproic acid, 4g of glycine and 20g of lysine respectively into a 250ml three-neck bottle, add 100ml of water, dehydrate at 200°C, heat up to 220°C after dehydration, and melt the reaction After 3 hours, continue to heat up to 230° C. for 3 hours to obtain a degradable composite material with a yield of 97%. The viscosity of the polymer in the obtained composite material is 3200Pa·S (240°C), the compressive strength is 102Mpa, the tensile strength is 95Mpa, the bending strength is 60Mpa, and the elastic modulus is 2.6Gpa; after soaking in simulated body fluid for 12w, the weight loss is 15.4 %.

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Abstract

The present invention relates to a bone-repairing composite polymer material containing a ceramic ingredient and a preparation method thereof. The bone-repairing composite polymer material is composed of the calcium phosphate ceramic ingredient and a polybasic amino acid polymer ingredient, wherein, the mass ratio of the calcium phosphate ceramic ingredient is between 5 percent and 30 percent, and the rest is the polybasic amino acid polymer ingredient. Epsilon-aminocaproic acid is polymerized with at least two other types of amine acids to form the polybasic amino acid polymer ingredient, wherein, the mole ratio of the epsilon-aminocaproic acid in the polybasic amino acid polymer ingredient is between 50 percent and 90 percent, and the rest is the other amine acids including aminoacetic acid, lactamic acid, phenylalanine, lysine and proline. Under the protection of a inert gas, the materials, the amine acids and the calcium phosphate, are sufficiently and uniformly dispersed into water and then heated, so that various forms of waters can be removed from the materials, and finally, the materials are polymerized in two steps, respectively under a temperature between 200 DEG C and 220 DEG C and a temperature between 230 DEG C and 250 DEG C. The bone-repairing composite polymer material, which has excellent mechanical property, bioactivity, biocompatibility and controllable degradation property, can be perfectly combined with the interface of the bone tissue, and moreover, the degradation product is non-toxic and non-irritant.

Description

technical field [0001] The invention relates to a composite polymer bone repair material containing ceramic components and a preparation method thereof, in particular to a bone repair material composed of ceramic components of calcium phosphate salts and polyamino acid polymers and a preparation method thereof. Background technique [0002] Various types of calcium phosphate salts, including hydroxyapatite (HA) and calcium phosphate, have been widely used as substitute materials for the repair and reconstruction of hard tissues such as human bone injuries. [0003] Hydroxyapatite (HA) is the calcium phosphate salt with the largest precipitation constant. Hydroxyapatite ceramics have high mechanical strength, the compressive strength reaches 500-1000MPa, the bending strength reaches 115-200MPa, and the Young's modulus reaches 80-110GPa. The phosphorus / calcium ratio of hydroxyapatite is similar to the inorganic components of human bone, so it has good biocompatibility and has...

Claims

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Application Information

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IPC IPC(8): A61L27/18C08L77/00C08K3/32C08G69/08
Inventor 严永刚李鸿吕国玉曹侠王云芳杨爱萍罗小满裴福兴宋跃明段宏
Owner SICHUAN GUONA TECH
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