40 results about "Hydroxyapatite ceramics" patented technology

An implant device for spinal interbody fusion surgery has a shape substantially similar to a human excavated disc space, and includes a first modular end section, at least one modular middle section disposed adjacent to the first modular end section, a second modular end section disposed adjacent to the modular middle section and wherein when the first end section, the middle section and the second end section are placed adjacent to each other, the implant device has a shape with is substantially oval, viewed from top, and a cross section which is bi-convex. The preferred embodiment of the implant device is manufactured from human bone material that has been formed into the shape of the modular components. Alternative embodiments are manufactured from non-human material such as hydrooxyapetite, ceramics, coral and other biodegradable material. Non-resorptable plastic and metal can be used as internal structural members of the implant modules.

The invention discloses a method for preparation of a bone hydroxyapatite-imitating bone repair material, nano hydroxyapatite ceramic powder and NH4HCO3 powder are mixed proportionally, after mixing, the powder is loaded into a gradient mold for mechanical pressing into a block pressed blank, the block pressed blank is put into a discharge plasma sintering furnace, heated to 950 DEG C and 1050 DEG C in the heating rate of 100 DEG / min, and then kept warm for 10-20min, and after demoulding, a nano scale bone gradient-imitating porous hydroxyapatite bone repair material is obtained. The nano scale bone gradient-imitating porous hydroxyapatite bone repair material is prepared by the method comprises outer and inner two layers, the porosity is 34% to 80%, and the pore scale is controllable in the range of 100-500mum, and the nano scale bone gradient-imitating porous hydroxyapatite bone repair material has the advantages of fine grain size, composition purity, no residual pore former, controllable mechanical properties and degradation rate and the like, and can be used as a good artificial bone tissue repair material.

A fixing member for an implant which comprises a tube or a pillar made of an hydroxyapatite ceramics at least one part of which is a ceramics porous article consisting essentially of a hydroxyapatite formed by agitation foaming, in which a number of approximately spherical pores mutually contact having pore structures communicated three-dimensionally opened at the contact area and having an averaged porosity of from 65% to 85%. A method for fixing an implant comprising a step of inserting an implant whose at least one part of the periphery is integrated with a hydroxyapatite ceramics into an implant insertion site of an alveolar bone or a gnathic bone. A method for fixing an implant, a fixing member for the implant and an implant composite in order to reinforce an implant insertion site by compensating or regenerating an alveolar bone or a gnathic bone on an implant treatment in dentistry or in oral surgery is obtained.

The invention relates to a preparation method of a porous titanium / hydroxyapatite composite material, and belongs to the technical field of biomedical material preparation. According to the method, metal pure titanium powder and hydroxyapatite ceramic powder are uniformly mixed; after the materials are uniformly mixed, the mixture is mixed with ammonium hydrogen carbonate to obtain mixed powder; the mixed powder is mechanically pressed into blocky pressed green compacts; then, the blocky pressed green compacts are put into a discharging plasma sintering furnace to be sintered in a gradient heating mode; demolding is performed, and the titanium / hydroxyapatite composite material is obtained. The porous titanium / hydroxyapatite composite material obtained through preparation has the characteristics that the elasticity modulus is low; the pore parameters are controllable; the physical adaptability is good, and the like. The porous titanium / hydroxyapatite composite material also has good bioactivity and bone combining capability. Along with the bone induction effect of the hydroxyapatite in the human body, the bone tissues are gradually induced to grow into the pores to realize the biological fixation, so that the bone integration effect is greatly improved. The material is particularly applicable to biomedical engineering with human body hard tissue defects, such as artificial joints, artificial bones and dental implants.

The invention discloses a 3D-printing in-situ rare earth doped titanium matrix composite material activated bone implant. The implant comprises an in-situ rare earth doped titanium matrix composite material formed by in-situ rare earth Re2O3, an in-situ TiB ceramic phase and a hydroxyapatite ceramic phase. A preparation method comprises the steps that B2O3 powder and rare earth Re powder are subjected to ball-milling mixing by adopting a high-energy ball milling technology under inert gas shielding, and B2O3 / Re mixed powder is obtained; the B2O3 / Re mixed powder, hydroxyapatite powder and 3D-printing dedicated spherical titanium alloy powder are weighed, a low-energy ball milling technology under inert gas auxiliary shielding is adopted, and titanium alloy composite material powder is obtained; and under the argon atmosphere, the in-situ rare earth Re2O3, in-situ TiB ceramic and hydroxyapatite ceramic reinforced titanium matrix composite material activated bone implant is formed by means of laser 3D-printing. According to the method, the service performance of the titanium alloy bone implant is improved through rare earth in-situ doping, and precision manufacturing of the high-performance complex-structure titanium alloy activated bone implant can be achieved.

The invention relates to a preparation method of hydroxyapatite biological ceramics with strontium cooperated with an ordered micrometer structure for osteogenesis. The preparation method comprises the following steps: (1) preparing strontium doped hydroxyapatite powder; (2) uniformly mixing the strontium doped hydroxyapatite powder and a binder, placing the mixture in a mold with a bottom lined with an organic plastic mesh screen, dry pressing and molding, sintering at a high temperature, and cooling, thus obtaining the strontium doped hydroxyapatite ceramics. Compared with the prior art, byadopting the dry pressing and molding technology, the organic plastic mesh screen with a mesh aperture dimension of 25 to 75 micrometers is used as a template for regulating and controlling an orderedstructure, the structure with the surface having ordered micrometer patterns is prepared on the basis of the strontium doped hydroxyapatite, so that the hydroxyapatite biological ceramics have betteradhesion, proliferation and differentiation of osteoblast; and the preparation method is novel, simple, easy, and capable of preparing the strontium doped surface ordered micrometer structure hydroxyapatite biological ceramics having a synergistic osteogenic differentiation effect in a low-cost and large-scale manner without special equipment.

The invention relates to biological medical material which is compounded by biological ceramics, namely, hydroxyapatite ceramics, calcium phosphate ceramics, and silicon rubber. The biological ceramics and silicon rubber compound biological medical material of the invention is used to choose corresponding dies for manufacturing artificial nose bridges, artificial mandibles, artificial temples, artificial malar bones, plastic plates, or other implanted supports. After being implanted in the body, the biological ceramics can gradually degrade peripheral tissues for gradually growing in, which can improve the growth of new bones. The surface has micro-pore type structures, which is favorable for adhesion and growth of cells. The invention provides a preparing process of the biological ceramics and silicon rubber compound biological medical material.

A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.

A hydroxyapatite ceramic hybrid material includes a hydroxyapatite ceramic structure having pores therein and a biodegradable polymer included in the pores in the hydroxyapatite ceramic structure. The biodegradable polymer can be a poly L-lactic acid polymer. A method for preparing a hydroxyapatite ceramic-biodegradable polymer hybrid material includes preparing a porous hydroxyapatite ceramic containing pores having an average pore diameter of 10 μm or larger; and forming a biodegradable polymer in the pores of the porous hydroxyapatite ceramic. The porous hydroxyapatite ceramic may be prepared by: preparing a slurry comprising hydroxyapatite fibers and heat-degradable particles in a selected solvent; filtering the slurry to obtain a paste; preparing a molded body using the paste; compacting the molded body to produce a green compact; and firing the green compact at a temperature at least 1000° C. to produce a porous hydroxyapatite ceramic structure.

The invention discloses a biological bionic bone material doped with three elements. A main material of the biological bionic bone material is hydroxyapatite; Zn<2+>, Sr<2+> and SeO<32-> ions are doped in crystal lattices of the hydroxyapatite; the Zn <2+> and Sr<2+> ions partially replace calcium ions in the crystal lattices of the hydroxyapatite; and the SeO<32-> ions partially replace phosphateions in the crystal lattices of the hydroxyapatite. According to the invention, a hydration reaction is carried out mainly through a high-flux hydrothermal synthesis device to prepare the biologicalbionic bone material doped with three elements. The biological bionic bone material is mainly used for application to preparation of a bionic bone or an osteochondral substitute, and application to preparation of a medicine for bone or osteochondral regeneration. According to the invention, the zinc-strontium-selenium three-element doped hydroxyapatite ceramic material with the optimal biologicalperformance material content is prepared and selected by using the high-flux hydrothermal synthesis device, and the clinically-used biological bionic bone material with the effects of promoting bone growth, reducing surgical infection and inhibiting cancer recurrence is provided for large-section bone defects caused by osteosarcoma.

The invention relates to a method for growing a patterned graphene film on the surface of hydroxyapatite, which comprises: firstly, forming a patterned copper layer on a hydroxyapatite ceramic substrate by an electron beam evaporation process; secondly, catalytically decomposing hydrocarbons on the patterned surface, and growing the patterned graphene film on the surface of the material; and finally, verifying the possibility for growing cells on the material. The hydroxyapatite material with the patterned graphene film allows the behavior / density of the cells to be regulated by adding an accurate local electric field on the graphene layer; and combining the bone growth promoting capacity of the hydroxyapatite, a new material is provided for promoting / helping bones to grow.

The invention belongs to the field of medical materials for bone injury repair and discloses silicon-containing grain boundary phase modified hydroxyapatite ceramic, a bone injury repair material anda preparation method of the hydroxyapatite ceramic. The method comprises the steps as follows: firstly, a silicon source, triethyl phosphate and calcium nitrate tetrahydrate fully react in the ratio to produce silicon-containing mixed sol, then, a pre-sintered hydroxyapatite body is impregnated and permeated with the silicon-containing mixed solution under the vacuum negative-pressure condition, drying and high-temperature sintering are performed, and the silicon-containing grain boundary phase modified hydroxyapatite ceramic is obtained. According to the silicon-containing grain boundary phase modified hydroxyapatite ceramic prepared with a sol permeation method, a silicon-containing grain boundary phase formed during sintering coats hydroxyapatite grains, and combination of hydroxyapatite grains is improved, so that the material has good mechanical performance. The silicon-containing grain boundary phase introduces silicon elements for the hydroxyapatite ceramic, the degradation property of hydroxyapatite is improved, and the osteogenesis performance of the material is improved.

The invention belongs to the technical field of bioengineering and material science, and particularly relates to a preparation method of hydroxyapatite porous ceramic capable of being used as an artificial bone. The preparation process can be realized according to the following steps: taking deionized water, a dispersing agent, a binder, hydroxyapatite ceramic powder and a pore-forming agent as initial raw materials, and carrying out ball-milling mixing to obtain stably dispersed slurry; drying the obtained slurry in a rotary evaporator, and sieving the slurry for later use; carrying out mechanical press molding on the sieved powder, demolding the material, and drying the material in a drying oven; and sintering the dried green body in an air atmosphere furnace to obtain the hydroxyapatiteporous ceramic. The prepared material is reliable in performance, and has the characteristics of simple process, easiness in large-scale production and the like.

The invention provides a method for preparing a titanium / hydroxyapatite biological scaffold through the die-free direct-write molding technology. The method comprises the following steps: the mixed powder of hydroxyapatite powder and titanium metal powder is dispersed into a medium, so as to prepare a titanium / hydroxyapatite ceramic slurry with the solid phase content of 50-80wt percent; a three-dimensional structural map is designed in advance through a CAD software, and then converted to be code language capable of being recognized by a computer, the titanium / hydroxyapatite ceramic slurry is placed into an extruding needle cylinder, under the driving of a three-dimensional platform, the extruding needle cylinder moves along the path appointed by the computer and extrudes for formation layer by layer and simultaneously, therefore, a multilayer ordered three-dimensional porous network-like structure green body is formed; and procedures of drying, sintering and heat treating are performed on the multilayer ordered three-dimensional porous network-like structure green body, and a three-dimensional biological scaffold is obtained.

The invention relates to a membrane coated hydroxyapatite (HA) ceramic spinal fusion cage prepared by adding HA powder to a polyether-ether-ketone material and sintering, and the surface of the spinal fusion cage is coated by a polylactic acid (PLA) membrane, wherein the HA can adjust and control the composition and grain size of the material to achieve the best mechanical property of the material; and the PLA membrane with high surface molecular weight can further effectively overcome the brittleness of HA, and especially improves the fracture toughness, thus overcoming the brittleness of the conventional HA ceramics, and meeting the mechanical requirements on the spinal fusion cage. Simultaneously, the HA ceramic spinal fusion cage provided by the invention can keep the biological activity of the HA and achieve bony fusion with bone in vivo. The invention also comprises the membrane coating method of the membrane coated HA ceramic spinal fusion cage.

The invention belongs to the technical field of biomedical materials and in particular relates to a double-gradient artificial vertebral lamina and a preparation method thereof. The double-gradient artificial vertebral lamina is a base body with a trapezoid cross section and an axial length, wherein the base body is composed of an upper layer, a middle layer and a lower layer; the upper layer andthe lower layer are dense hydroxyapatite ceramic layers; the middle layer is a porous double-phase calcium phosphate ceramic layer. The artificial vertebral lamina provided by the invention has a dense / porous / dense trapezoid sandwich structure; compared with the prior art, the artificial vertebral lamina has higher tissue compatibility and anti-adhesion performance; meanwhile, the artificial vertebral lamina has excellent osteoinduction performance, is simple in structure and convenient to implant and is suitable for being popularized and applied in a large range.

The invention relates to a cable, in particular to a copper-sheathed mineral insulation fire-resistant cable, aiming at solving a technical problem of providing the copper-sheathed mineral insulation fire-resistant cable with good fire-resistance and corrosion resistance; the copper-sheathed mineral insulation fire-resistant cable comprises a conductor as well as an inorganic ceramic power insulation layer, a copper sheath and an oxygen insulation and corrosion-resistant sheath, which are covered on the conductor sequentially; the oxygen insulation and corrosion-resistant sheath is made from hydroxyapatite ceramics; and a waterproof barrier layer is arranged between the inorganic ceramic power insulation layer and the copper sheath and made from polyvinyl chloride. The copper-sheathed mineral insulation fire-resistant cable has the effects of good fire-resistance and insulation and is waterproof and corrosion-resistant and the like.

Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.

Disclosed are a porous hydroxyapatite bioceramic and a preparing method thereof. The porous hydroxyapatite bioceramics of the present invention has suitable pore diameters and distribution, porosity, pore-through situations, and pore surface morphology for bone tissue growth, and not only has large pores allowing a new bone to grow into, but also has abundant flake-shaped pores in pore walls, thus transferring osteogenesis. In the preparing method of the present invention, diameters and distribution of polymeric fibers are arranged appropriately in a die in advance, aqueous hydroxyapatite slurry is frozen and solidified by using orientated temperature field to make hydroxyapatite powder particulates to agglomerate and rearrange under of pushing and thrusting of an orientated grown ice crystal, a resulting ice block is frozen and dried to sublime the ice crystal before sintering is performed. The method can perform fine regulating may be performed on the porous microstructure. And porous hydroxyapatite prepared by the present invention has the high pore-through rate and the high porosity, suitable for bone tissue growth.

The present invention discloses a method of ashes preservation by hydroxyapatite ceramic. The invention is characterized by sintering the ashes at a high temperature, and curing the ceramic, thereby reducing the storage volume of the ashes, reducing the amount of heavy metal ions dissolved out, and preventing the ashes from becoming mildewed and being polluted by microbes. The method of ashes preservation by the ceramic can be widely used for processing various ashes, and can also be used for preparing the ceramic of ashes according to the figure and the appearance of a dead person during the dead person's lifetime, so as to cherish the memory of the dead.

The invention relates to a preparation method of a ceramic ball for preparing an arbitrarily shaped ceramic bracket. The preparation method comprises the following steps of: (1) preparing a chitosan solution containing a calcium-phosphorus precursor; (2) dropwise adding the chitosan solution containing the calcium-phosphorus precursor into a NaOH solution with the concentration of 1-5wt% to obtainchitosan / hydroxyapatite composite microspheres; and (3) sintering the chitosan / hydroxyapatite composite microspheres to obtain the hydroxyapatite ceramic ball. The ceramic ball prepared by the methodhas a regular spherical surface. The ceramic ball manufactured by the method can be arbitrarily shaped when being filled to form a ceramic bracket, and does not need to be fixed when being formed, sothat the method is convenient and quick. Meanwhile, compared with a traditional method, the method for manufacturing the ceramic ball is lower in cost.

The invention discloses a hydroxyapatite ceramic as well as a preparation method and application thereof. The preparation method comprises the steps of conducting dry pressing, specifically, filling powder into a mold, and pressing the powder into a dry blank under the static pressure of not less than 10MPa, wherein the powder at least comprises silk fibroin-hydroxyapatite composite material powder, a silk fibroin-hydroxyapatite composite material is prepared by assembling hydroxyapatite on silk fibroin through an in-situ mineralization method, and the weight ratio of the silk fibroin to the hydroxyapatite is 3: (6-8); and conducting sintering, specifically, removing silk fibroin in the dry blank, and converting hydroxyapatite into ceramic so as to obtain the hydroxyapatite ceramic. The preparation method is simple and short in time consumption; the obtained material has regular micron pores with the pore diameter being less than or equal to 7 microns, the porosity is high, and the pores are communicated with one another; and the material has high compressive strength and good liquid permeability, and is suitable for guiding bone tissue regeneration to meet the requirements for compressive strength, high porosity and high permeability.

The invention belongs to the field of bone tissue replacement materials, and relates to a porous hydroxyapatite ceramic / graphene composite bone tissue replacement material and a preparation method thereof. The preparation method of the hydroxyapatite ceramic / graphene composite bone tissue replacement material sequentially comprises the steps of preparing nano hydroxyapatite / chitosan / graphene slurry, preparing porous hydroxyapatite / graphene composite stent, and sintering molding, wherein a method for preparing the composite stent comprises the steps of immersing polyurethane sponge in the hydroxyapatite / chitosan / graphene slurry, squeezing the polyurethane sponge to fill pores in the polyurethane sponge with the slurry, and vacuum-drying the polyurethane sponge, wherein during vacuum drying,the vacuum temperature is 40-80 DEG C, and the vacuum degree is 60-90 KPa. The bone tissue replacement material has a porous structure and high mechanical strength and porosity, and can meet the requirements of bone tissue replacement materials.

The invention relates to a stirring device with a good heat preservation effect for producing hydroxyapatite ceramic. The device comprises a box body, a connecting cover, a stirring tank and two fixing blocks. The stirring tank and the fixed block are arranged in the box body; the stirring tank is in a cylindrical shape; the fixed blocks are circumferentially and uniformly arranged at the bottom end of the stirring tank by taking the axis of the stirring tank as the center; the stirring tank is fixedly connected with the bottom in the box body through a fixing block; a connecting hole is formed in the top of the box body, and the connecting cover is matched with a connecting port; the connecting cover covers the top of the box body, and a gap is formed between the connecting cover and thetop end of the stirring tank; a heating device is arranged on the stirring tank; a stirring mechanism is arranged in the stirring tank; an auxiliary mechanism is arranged in the box body. Through thestirring mechanism, the stirring device realizes the function of stirring raw materials; and in addition, the heat preservation effect is improved through the auxiliary mechanism.

A spinal fusion cage, has at least hydroxyapatite ceramic, a grain size of the hydroxyapatite ceramic is less than 300 nm. The spinal fusion cage of the invention improves mechanical strength and especially fracture toughness, overcomes brittleness of a conventional hydroxyapatite ceramic, and meets mechanical requirements for the spinal fusion cage. Meanwhile, the spinal fusion cage of the invention maintains biological activity of hydroxyapatite, and facilitates bone fusion with bones within a body.

The invention relates to a method for preparing hydroxyapatite ceramic by combining a microwave hydrothermal method and a microwave sintering method. The method comprises the following steps: firstly,mixing a calcium chloride water solution with a disodium hydrogen phosphate water solution through an ultrasonic spraying method, then transferring the mixed solution into a microwave reactor to carry out reactions to obtain nano scale hydroxyapatite powder, finally, pressing the powder into a green body, and carrying out microwave sintering molding. By adopting the method, the hydroxyapatite powder with good dispersity and high crystallinity can be rapidly prepared in a large scale in a short time, the sintering temperature is reduced, the sintering time is shortened in the sintering process, the grain growth is effectively inhibited, and the prepared ceramic has higher strength and better performance.

The invention belongs to the technical field of biomedical materials and in particular relates to a double-gradient artificial vertebral lamina and a preparation method thereof. The double-gradient artificial vertebral lamina is a base body with a trapezoid cross section and an axial length, wherein the base body is composed of an upper layer, a middle layer and a lower layer; the upper layer andthe lower layer are dense hydroxyapatite ceramic layers; the middle layer is a porous double-phase calcium phosphate ceramic layer. The artificial vertebral lamina provided by the invention has a dense / porous / dense trapezoid sandwich structure; compared with the prior art, the artificial vertebral lamina has higher tissue compatibility and anti-adhesion performance; meanwhile, the artificial vertebral lamina has excellent osteoinduction performance, is simple in structure and convenient to implant and is suitable for being popularized and applied in a large range.