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Membrane coated hydroxyapatite ceramic spinal fusion cage

A technology of laminating hydroxyapatite and hydroxyapatite powder, which is applied in medical science, surgery, coating, etc.

Inactive Publication Date: 2011-09-21
BEIJING ALLGENS MEDICAL SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional hydroxyapatite ceramics are brittle materials and can only be used for artificial joint coatings, ear bones and other biomaterial applications under non-load-bearing conditions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The spinal fusion cage is in the shape of a rectangular banana, with a width of 14mm, a length of 25mm, a height of 10mm, and a wall thickness of 2.5mm. Suitable for patients with L5 / S1 intervertebral disc herniation.

[0028] The hydroxyapatite ceramic spinal fusion device is made of hydroxyapatite ceramic material with a grain size of less than 100 nanometers. The polyetheretherketone PEEK material is added to the above-mentioned hydroxyapatite ceramic material and sintered to form a fusion device, and then its The surface is covered with polylactic acid with a molecular weight of 150,000 to 250,000 to make a hydroxyapatite ceramic spinal fusion cage of the above size.

[0029] Polylactic acid coating method: ① Dissolve a certain amount of PDLLA in acetone to prepare a 10% PDLLA solution. ②The HA ceramic spinal cage is subjected to silane coupling treatment, so that a layer of ultra-thin organic nano-film layer (50-500nm) with a three-dimensional network structure si...

Embodiment 2

[0032] The structure size and laminating method of the spinal cage are the same as in Example 1. However, the fusion cage has a slope of 5 degrees, which is lower at the front and higher at the rear. The width is 14mm, the length is 25mm, the height is 10mm, and the wall thickness is 2.5mm. Suitable for patients with L4 / L5 intervertebral disc herniation.

[0033] The hydroxyapatite ceramic spinal fusion device is made in the same way as before. The material used in the spinal fusion device is hydroxyapatite ceramic material with a grain size of 60 nanometers. The amount is higher than 20GPa.

Embodiment 3

[0035] The structure size and laminating method of the spinal cage are the same as in Example 1. The material used for the spinal fusion cage is hydroxyapatite ceramic material with a grain size of less than 65 nanometers. The polyetheretherketone PEEK material is added to the above-mentioned hydroxyapatite ceramic material, and the fusion device is prepared by sintering in two-stage or multi-stage method. After being treated with silane coupling, the thickness of the laminated PLA reaches 0.5mm. Suitable for patients with L5 / S1 intervertebral disc herniation. It is measured that its compressive strength is higher than 150MPa, and its elastic modulus is higher than 15GPa.

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Abstract

The invention relates to a membrane coated hydroxyapatite (HA) ceramic spinal fusion cage prepared by adding HA powder to a polyether-ether-ketone material and sintering, and the surface of the spinal fusion cage is coated by a polylactic acid (PLA) membrane, wherein the HA can adjust and control the composition and grain size of the material to achieve the best mechanical property of the material; and the PLA membrane with high surface molecular weight can further effectively overcome the brittleness of HA, and especially improves the fracture toughness, thus overcoming the brittleness of the conventional HA ceramics, and meeting the mechanical requirements on the spinal fusion cage. Simultaneously, the HA ceramic spinal fusion cage provided by the invention can keep the biological activity of the HA and achieve bony fusion with bone in vivo. The invention also comprises the membrane coating method of the membrane coated HA ceramic spinal fusion cage.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a spinal fusion device with a PLA-coated film on the surface of hydroxyapatite ceramics. Background technique [0002] Spinal intervertebral fusion has been widely used in the treatment of spinal degenerative diseases, spinal fractures, dislocations, etc. Its main function is to effectively maintain the height of the intervertebral space and stabilize the fusion segment, so as to achieve intervertebral bony fusion. Spinal fusion is an effective means of treating spinal diseases such as spinal tuberculosis, infection, deformity, degenerative disease and intervertebral disc injury. The intervertebral fusion device has the function of stretching the intervertebral space, making the anterior longitudinal ligament in a state of tension, restoring the intervertebral height, and realizing the stability of the intervertebral fusion device and promoting the intervertebral fusion throug...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/10
Inventor 崔福斋王昶明郭文广连小洁朱锦文
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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