Hydroxylapatite ceramic spinal fusion device

Abstract

The invention discloses a hydroxyapatite ceramics spinal fusion cage, and the material of the spinal fusion cage is the hydroxyapatite ceramics material, the grain size of which is less than 300 nanometers. The hydroxyapatite ceramics spinal fusion cage of the invention can enhance the mechanical strength and especially improve fracture ductility, thus overcoming the brittleness of ordinary hydroxyapatite ceramics and satisfying the dynamical requirement of the spinal fusion cage. Furthermore, the hydroxyapatite ceramics spinal fusion cage can keep the bioactivity of the hydroxyapatite and achieve synosteosis with bones in the human body.

Description

technical field [0001] The invention belongs to the field of biomedical materials. It particularly relates to a hydroxyapatite ceramic spinal fusion device. Background technique [0002] Spinal fusion is an effective means of treating spinal diseases such as spinal tuberculosis, infection, deformity, degenerative disease and intervertebral disc injury. The intervertebral fusion device can stretch the intervertebral space, make the anterior longitudinal ligament in a state of tension, restore the intervertebral height, and realize the stability of the intervertebral fusion device and promote the intervertebral fusion through the contraction of the lumbar muscles and the compression of the intervertebral fusion device by its own body weight. Bone fusion between bodies. Spinal fusion surgery was first proposed by Hibbs in 1911, and after Mercer proposed the theory of intervertebral fusion in 1936, spinal fusion achieved rapid development and has now become an important means ...

AI Technical Summary

Problems solved by technology

However, the elastic modulus of metal spinal fusion is much higher than that of cortical bone, which will cause stress shielding in the body, resulting in complications such as osteoporosis, bone atrophy, collapse of the implantation site, loosening or slippage of the fusion cage, etc.

Moreover, the debris produced by the metal fusion device causes the body to produce macrophages, interleukin-1, interleukin-6, prostaglandin E2, tumor necrosis factor, etc., affecting bone fusion

In addition, metal materials cannot pass through X-rays, which affects the observation of bone fusion sites after surgery

[0004] Spinal fusion cages made of synthetic non-metallic and non-degradable materials (such as polyetheretherketone, PEEK), although the elastic modulus matches the vertebral bone, have good corrosion resistance, and can transmit X-rays, but As it cannot be degraded in the body, it will eventually require a second surgery to remove it

The second operation not only causes high cost, but also causes secondary harm to the patient's physiology and causes great psychological pressure

However, conventional hydroxyapatite ceramics are brittle materials, in which the hydroxyapatite grains are relatively large (generally greater than 2 microns), and its compressive strength is low (less than 0.5GPa), which can only be used for artificial joint coatings. Application of biomaterials in non-load-bearing conditions such as bone