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Hydroxyapatite ceramic as well as preparation method and application thereof

A technology of hydroxyapatite and ceramics, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of low compressive strength of materials, irregular micro-pore and hundred-micron pore structure, etc., and achieve high porosity and liquid Absorbency, simple process, low energy consumption

Active Publication Date: 2021-11-02
HUBEI SAILUO BIOLOGICAL MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Aiming at the problem of low compressive strength of the material caused by the irregular structure of micron pores and hundreds of micron pores contained in existing bone repair materials, the present invention provides a method for preparing hydroxyapatite ceramics with regular micron pores with a pore diameter of <10 μm. method, the prepared hydroxyapatite ceramics have high porosity and interconnected pores, and have certain compressive strength and good liquid permeability

Method used

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  • Hydroxyapatite ceramic as well as preparation method and application thereof
  • Hydroxyapatite ceramic as well as preparation method and application thereof
  • Hydroxyapatite ceramic as well as preparation method and application thereof

Examples

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Embodiment 1

[0034] The present embodiment Ca / P feed ratio is 1.67.

[0035] (1) Dissolve 27.84mL concentrated phosphoric acid in 1L pure water, dissolve 30g silk fibroin in 330mL water, and stir vigorously while mixing the two to obtain a silk fibroin-phosphate solution; dissolve 49.95g calcium hydroxide in 4L water to obtain a calcium hydroxide suspension.

[0036] (2) Divide the silk fibroin-phosphoric acid solution into 8 equal volumes, add it to the calcium hydroxide suspension in 8 times, and adjust the pH to 10-11 after each addition, and react at 70°C for 30 minutes; finally Add silk fibroin-phosphoric acid solution once to react for 1h.

[0037] (3) Remove the supernatant after incubating the reacted solution overnight, and centrifuge at a speed of 5000r / min to obtain a solid substance; the solid substance is washed 3 times with pure water, and the supernatant is removed; finally, it is dried in an oven at 40°C Dry the solid material until it is completely irregular in size.

...

Embodiment 2

[0044] According to the preparation method of Example 1, under the condition that other parameters of Example 1 remain unchanged, the static pressure is changed, and the influence of the static pressure on the compressive strength, elastic modulus, and liquid absorption of the final product is studied. The results are shown in Table 1:

[0045] The final product properties obtained under the different static pressure conditions of table 1

[0046] Ca / P feed ratio static pressure Compressive strength Elastic Modulus liquid absorbency 1.67 1MPa 0.8MPa 11.43MPa 81.20％ 1.67 3 MPa 1.2 MPa 17.14MPa 75.32％ 1.67 5MPa 2.0MPa 25.1MPa 75.13％ 1.67 10MPa 2.5MPa 35.71 MPa 70.11％ 1.67 20MPa 17.7MPa 252.86MPa 65.11％

[0047] The results show that as the static pressure increases, the compressive strength and elastic modulus of the final product increase, and the liquid absorbency decreases. When the static pressure i...

Embodiment 3

[0049] In this embodiment, the Ca / P feed ratio is controlled to be 1.50, that is, the control step (1) is: dissolve 6.96mL of concentrated phosphoric acid in 0.25L of pure water, dissolve 7.5g of silk fibroin in 82.5mL of water, and mix the two together. Stir vigorously to obtain a silk fibroin-phosphate solution; dissolve 11.318g of calcium hydroxide in 1L of water to obtain a calcium hydroxide suspension. All the other steps and parameters are the same as in Example 1. Change the static pressure to study the effect of static pressure on the compressive strength, elastic modulus and liquid absorption of the final product. The results are shown in Table 2:

[0050] The final product properties obtained under the different static pressure conditions of table 2

[0051] Ca / P feed ratio static pressure Compressive strength Elastic Modulus liquid absorbency 1.50 5MPa 2.6MPa 37.14 MPa 60.32％ 1.50 10MPa 7.2MPa 102.86 MPa 65.22％ 1.50 20...

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Abstract

The invention discloses a hydroxyapatite ceramic as well as a preparation method and application thereof. The preparation method comprises the steps of conducting dry pressing, specifically, filling powder into a mold, and pressing the powder into a dry blank under the static pressure of not less than 10MPa, wherein the powder at least comprises silk fibroin-hydroxyapatite composite material powder, a silk fibroin-hydroxyapatite composite material is prepared by assembling hydroxyapatite on silk fibroin through an in-situ mineralization method, and the weight ratio of the silk fibroin to the hydroxyapatite is 3: (6-8); and conducting sintering, specifically, removing silk fibroin in the dry blank, and converting hydroxyapatite into ceramic so as to obtain the hydroxyapatite ceramic. The preparation method is simple and short in time consumption; the obtained material has regular micron pores with the pore diameter being less than or equal to 7 microns, the porosity is high, and the pores are communicated with one another; and the material has high compressive strength and good liquid permeability, and is suitable for guiding bone tissue regeneration to meet the requirements for compressive strength, high porosity and high permeability.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials and the field of bone repair materials, in particular to a hydroxyapatite ceramic and its preparation method and application. Background technique [0002] The study of artificial bone grafts has become a research hotspot in bone tissue engineering in recent years. As one of the bone tissue engineering materials, bioactive ceramics have a similar composition to natural bone and have excellent biocompatibility and bioactivity. However, it has low mechanical strength and typical brittleness, making it unsuitable for bone replacement and repair. [0003] The apatite materials on the market mainly include powdered or granular bone meal materials prepared from this material, or bone substitute or bone repair materials added with natural (synthetic) polymer materials. The main characteristics of powdery or granular synthetic apatite materials are the same chemical composition as human bon...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622A61L27/12A61L27/56
CPCC04B35/447C04B35/622A61L27/12A61L27/56A61L2430/02C04B2235/96Y02P40/60
Inventor 张辰铭
Owner HUBEI SAILUO BIOLOGICAL MATERIAL CO LTD
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