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Biological bionic bone material doped with three elements and preparation method and application thereof

A biomimetic bone and three-element technology is applied in the field of biomimetic bone materials doped with three elements and its preparation, which can solve the problems of lack of substantial help in the treatment of osteosarcoma, increasing the research and development process of bone materials, and complex synthesis and screening processes. Achieve the effect of reducing infection and cancer recurrence, facilitating postoperative rehabilitation, and inducing apoptosis of osteosarcoma cells

Inactive Publication Date: 2021-02-19
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since osteosarcoma is difficult to completely clear up, the possibility of recurrence of bone cancer after resection is relatively high, and certain inflammatory reactions will be caused during the operation and repair process. Simply using hydroxyapatite to fill bone defects can only guarantee After implantation, there is no obvious immune rejection reaction, and the mechanical properties have a certain bearing capacity, which is of no substantial help to the subsequent treatment of osteosarcoma.
The synthesis and screening process of hydroxyapatite materials in the past is relatively complicated. The doping of each element requires the preparation of a large number of doped samples with gradient concentrations to select the optimal doping amount. There are more combinations of various elements, which require A lot of time, which also increases the research and development process of new bone materials

Method used

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  • Biological bionic bone material doped with three elements and preparation method and application thereof
  • Biological bionic bone material doped with three elements and preparation method and application thereof
  • Biological bionic bone material doped with three elements and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] This embodiment provides a biomimetic bone material doped with three elements, the main material of which is hydroxyapatite, and the lattice of said hydroxyapatite is doped with Zn 2+ 、Sr 2+ , SeO 3 2- ions, the Zn 2+ 、Sr 2+ ions partially replace the calcium ions in the hydroxyapatite lattice, the SeO 3 2- The ions partially replace the phosphate ions in the hydroxyapatite lattice.

[0042] Concrete preparation method is:

[0043] The biomimetic bone material prepared by co-doping hydroxyapatite powder with the three elements of zinc, strontium and selenium was obtained through a high-throughput hydrothermal synthesis device for a hydrothermal reaction at a temperature of 150°C for 3 hours.

[0044] During the preparation of the hydrothermal reaction solution, doping elements were added at the same time, and zinc nitrate hexahydrate (Zn(NO 3 ) 2 ·6H 2 O) as zinc source, strontium nitrate (Sr(NO 3 ) 2 ) is the source of strontium, sodium selenite (Na 2 SeO ...

Embodiment 2

[0050] This example is aimed at the biomimetic bone material doped with three elements prepared in the above example, and its morphology and structure analysis experiment is carried out:

[0051] (1) Experimental equipment: including scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS).

[0052] (2) Experimental principle: Scanning electron microscopy (SEM) is a characterization method used to observe the surface morphology of materials. Energy dispersive spectroscopy (EDS) roughly detects the elemental composition of the sample.

[0053] (3) Experimental process: Take an appropriate amount of bionic bone material powder doped with three elements and evenly disperse it in absolute ethanol and ultrasonically disperse it for 5 minutes. After the dispersion is uniform, drop it on the silicon chip, and fix it on the metal sample tray after it is completely dry. Put it on (fixed with conductive glue) and spray gold (70s), dry and store at room temperature fo...

Embodiment 3

[0058] In this embodiment, an experimental analysis of phase and composition is carried out on the biomimetic bone material doped with three elements prepared in the above embodiments.

[0059] (1) Experimental principle: X-ray diffraction (X-ray diffraction; XRD) is used to analyze the information such as the crystal phase composition of the material.

[0060] (2) Experimental process: Take a certain amount of completely dry bionic bone material powder sample doped with three elements and evenly spread it in the frosted groove of the glass slide, compact it softly and slowly with a glass sheet, and then test it on the machine (test Conditions: Cu-Kα, 35mA, 45kV).

[0061] (3) Experimental conclusion:

[0062] The obtained XDR data pattern of the biomimetic bone material doped with three elements, such as image 3 shown.

[0063] according to image 3 It can be seen that the peaks contained in all groups of samples are the characteristic peaks of HA, and there are no other...

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Abstract

The invention discloses a biological bionic bone material doped with three elements. A main material of the biological bionic bone material is hydroxyapatite; Zn<2+>, Sr<2+> and SeO<32-> ions are doped in crystal lattices of the hydroxyapatite; the Zn <2+> and Sr<2+> ions partially replace calcium ions in the crystal lattices of the hydroxyapatite; and the SeO<32-> ions partially replace phosphateions in the crystal lattices of the hydroxyapatite. According to the invention, a hydration reaction is carried out mainly through a high-flux hydrothermal synthesis device to prepare the biologicalbionic bone material doped with three elements. The biological bionic bone material is mainly used for application to preparation of a bionic bone or an osteochondral substitute, and application to preparation of a medicine for bone or osteochondral regeneration. According to the invention, the zinc-strontium-selenium three-element doped hydroxyapatite ceramic material with the optimal biologicalperformance material content is prepared and selected by using the high-flux hydrothermal synthesis device, and the clinically-used biological bionic bone material with the effects of promoting bone growth, reducing surgical infection and inhibiting cancer recurrence is provided for large-section bone defects caused by osteosarcoma.

Description

technical field [0001] The invention relates to the technical field of bionic bone materials, in particular to a bionic bone material doped with three elements and its preparation method and application. Background technique [0002] Osteosarcoma, also called osteogenic sarcoma, is a malignant primary bone tumor that occurs more commonly in adolescents or children under the age of 20. It is the most common bone cancer in children, accounting for about 5% of pediatric tumors. Typical osteosarcoma originates in the bone, so the clinical treatment of osteosarcoma is widely through local excision to treat osteosarcoma tumor tissue. After resection of osteosarcoma tumor tissue, a cavity of bone defect will be left, which is usually repaired with synthetic bone substitute material, such as hydroxyapatite, hydroxyapatite (Hydroxyapatite) , HAP) is the most important inorganic component of human bones and teeth. Because HAP has good biological activity and osteoconductivity, after ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/54C01B25/32
CPCA61L27/12A61L27/54A61L2300/10A61L2300/102A61L2300/404A61L2300/412A61L2300/416A61L2430/02C01B25/32C01B25/327
Inventor 翁杰林浩天宋可可黄浩文怡
Owner SOUTHWEST JIAOTONG UNIV
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