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Preparation method of porous titanium/hydroxyapatite composite material

A technology of hydroxyapatite and composite materials, which is applied in the field of preparation of porous titanium/hydroxyapatite composite materials, can solve the problems of bone resorption, atrophy implants, fall off, etc., and achieves the improvement of osteogenic activity and amount of bone formation. The effect of increasing, increasing the bond strength

Inactive Publication Date: 2016-01-20
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that the elastic modulus of the existing compact Ti-HA composite material is much higher than that of human bone, which will lead to problems such as bone resorption, atrophy until the implant falls off after being implanted in the body.

Method used

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  • Preparation method of porous titanium/hydroxyapatite composite material
  • Preparation method of porous titanium/hydroxyapatite composite material
  • Preparation method of porous titanium/hydroxyapatite composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of a biomedical porous Ti-HA composite material described in this embodiment specifically includes the following steps:

[0030] (1) Weighing: According to the mass percentage of Ti80% and HA20%, respectively weigh Ti metal powder with a particle size of 45 μm and a purity of 99.5% and HA powder with a particle size of 100 nm and a purity of 99.5%;

[0031] (2) Preparation of composite raw material powder: put the powder weighed in step (1) into the ball mill tank of the ball mill, vacuumize to 8Pa, and then ball mill and mix the powder for 2 hours to obtain the mixed Ti-HA powder;

[0032] (3) Weighing: 80% mixed Ti-HA powder, NH 4 HCO 3 20% by mass, respectively weigh the mixed Ti-HA powder and NH with an average particle size of 300 μm and a purity of analytically pure 4 HCO 3 Porogen powder;

[0033] (4) Add pore-forming factor: put the powder weighed in step (3) into the mixer and mix for 30 minutes to obtain the mixed powder;

[0034] (...

Embodiment 2

[0041] The preparation method of a biomedical porous Ti-HA composite material described in this embodiment specifically includes the following steps:

[0042] (1) Weighing: According to the mass percentage of Ti75% and HA25%, respectively weigh Ti metal powder with a particle size of 45 μm and a purity of 99.5% and HA powder with a particle size of 80 nm and a purity of 99.5%;

[0043] (2) Preparation of composite raw material powder: put the powder weighed in step (1) into the ball mill tank of the ball mill, vacuumize to 9Pa, and then ball mill and mix the powder for 3 hours to obtain the mixed Ti-HA powder;

[0044] (3) Weighing: Mixed Ti-HA powder 85%, NH 4 HCO 3 15% by mass, weigh the mixed Ti-HA powder and NH with an average particle size of 400 μm and a purity of analytically pure 4 HCO 3 Porogen powder;

[0045] (4) Add pore-forming factor: put the powder weighed in step (3) into the mixer and mix for 60 minutes to obtain the mixed powder;

[0046] (5) Preparation...

Embodiment 3

[0051] The preparation method of a biomedical porous Ti-HA composite material described in this embodiment specifically includes the following steps:

[0052] (1) Weighing: According to the mass percentage of Ti70% and HA30%, respectively weigh Ti metal powder with a particle size of 40 μm and a purity of 99.5% and HA powder with a particle size of 90 nm and a purity of 99.5%;

[0053] (2) Preparation of composite raw material powder: put the powder weighed in step (1) into the ball mill tank of the ball mill, vacuumize to 10Pa, and then ball mill and mix the powder for 4 hours to obtain the mixed Ti-HA powder;

[0054] (3) Weighing: Mixed Ti-HA powder 90%, NH 4 HCO 3 10% by mass, respectively weigh the mixed Ti-HA powder and NH with an average particle size of 500 μm and a purity of analytically pure 4 HCO 3 Porogen powder;

[0055] (4) Add pore-forming factor: put the powder weighed in step (3) into the mixer and mix for 35 minutes to obtain the mixed powder;

[0056] (...

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Abstract

The invention relates to a preparation method of a porous titanium / hydroxyapatite composite material, and belongs to the technical field of biomedical material preparation. According to the method, metal pure titanium powder and hydroxyapatite ceramic powder are uniformly mixed; after the materials are uniformly mixed, the mixture is mixed with ammonium hydrogen carbonate to obtain mixed powder; the mixed powder is mechanically pressed into blocky pressed green compacts; then, the blocky pressed green compacts are put into a discharging plasma sintering furnace to be sintered in a gradient heating mode; demolding is performed, and the titanium / hydroxyapatite composite material is obtained. The porous titanium / hydroxyapatite composite material obtained through preparation has the characteristics that the elasticity modulus is low; the pore parameters are controllable; the physical adaptability is good, and the like. The porous titanium / hydroxyapatite composite material also has good bioactivity and bone combining capability. Along with the bone induction effect of the hydroxyapatite in the human body, the bone tissues are gradually induced to grow into the pores to realize the biological fixation, so that the bone integration effect is greatly improved. The material is particularly applicable to biomedical engineering with human body hard tissue defects, such as artificial joints, artificial bones and dental implants.

Description

technical field [0001] The invention relates to a preparation method of a porous titanium / hydroxyapatite composite material, belonging to the technical field of preparation of biomedical materials. Background technique [0002] With the improvement of medical level, the requirements for mechanical properties, biocompatibility and biological activity of implanted biomedical materials for human body are getting higher and higher. Therefore, for biomedical titanium (Ti) implants, in addition to meeting the necessary mechanical properties, wear resistance and corrosion resistance, and biological safety, they also need to have good bioactivity and osseointegration (osseointegration) capabilities. Since products made from a single biomaterial cannot well meet clinical applications, it has become a new direction for biomedical materials to synthesize biomaterials with different advantages into biomedical composite materials using reasonable technology. Ti-hydroxyapatite (HA) biome...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/42
Inventor 张玉勤张磊何正员蒋业华周荣
Owner KUNMING UNIV OF SCI & TECH
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